Prevalence of neonatal hypothermia and its associated factors in East Africa: a systematic review and meta-analysis

Beletew, Biruk; Mengesha, Ayelign; Wudu, Mesfin; Abate, Melese

doi:10.1186/s12887-020-02024-w

Cited by 35 publications

(40 citation statements)

References 34 publications

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“…We used pre-specified inclusion criteria to further screen the full-text articles. Disagreements were resolved with third reviewer (GT) for the final decision on the selection of studies to be included in the analysis [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

“…The disagreement was resolved by the interference of a third reviewer. Studies were considered as high risk or poor quality, when it scored 3 and below [ 20 – 22 ] ( S2 Table ).…”

Section: Methodsmentioning

confidence: 99%

“…Using the extraction form two authors (BB and TG) extracted the data in collaboration. The third author (GT) independently assessed the accuracy of the data and discussions with a third reviewer were done when disagreements between reviewers occurred [ 20 , 22 ].…”

Section: Methodsmentioning

confidence: 99%

“…Sensitivity analysis was done to assess the impact of a single study on the pooled estimate. Using funnel plot subjectively and objectively by Egger’s regression test publication bias was assessed [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

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Magnitude of underweight, wasting and stunting among HIV positive children in East Africa: A systematic review and meta-analysis

2020

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Background Malnutrition on the background of HIV (Human Immunodeficiency Virus) infection is a complex medical condition that carries significant morbidity and mortality for affected children, with greater mortality from SAM (Severe Acute Malnutrition) among HIV-positive children than their HIV-negative peers. HIV-induced immune impairment heightened risk of opportunistic infection and can worsen nutritional status of children. HIV infection often leads to nutritional deficiencies through decreased food intake, mal-absorption and increased utilization and excretion of nutrients, which in turn can hasten death. Objective The aim of this systematic review and meta-analysis was to assess the magnitude of underweight, wasting and stunting among HIV positive children in East Africa. Methods The authors systematically reviewed and meta-analyzed studies that assessed the prevalence of underweight, wasting and stunting among HIV positive children in East Africa from PubMed, Cochrane Library, Google Scholar, and Gray Literatures using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guideline. The last search date was December 30/2019. The data was extracted in excel sheet considering country, study design, year of publication, prevalence reported. Then the authors transformed the data to STATA 14 for analysis. Heterogeneity across the studies was assessed by the Q and the I 2 test. A weighted inverse variance random-effects model was used to estimate the magnitude of underweight, wasting and stunting. The subgroup analysis was done by country, year of publication, and study design. To examine publication bias, a funnel plot and Egger’s regression test were used. Results For the analysis a total of 22 studies with 22074 patients were used. The pooled prevalence of under-weight, wasting, and stunting among HIV positive children in East Africa was found to be 41.63% (95%CI; 35.69–47.57; I 2 = 98.7%; p<0.001), 24.65% (95%CI; 18.34–30.95; I 2 = 99.2%; p<0.001), and 49.68% (95%CI; 42.59–56.77; I 2 = 99.0%; p<0.001) respectively. The prevalence of under-weight among HIV positive children was found to be 49.67% in Ethiopia followed by 42.00 in Rwanda. It was high among cohort studies (44.87%). Based on the year of publication, the prevalence of under-weight among HIV positive children was found to be 40.88% from studies conducted from January 2008-December 2014, while it was 43.68% from studies conducted from 2015–2019. The prevalence of wasting among HIV positive children was found to be 29.7% in Tanzania followed by 24.94% in Ethiopia. Based on the study design, the prevalence of wasting among HIV positive children was found to be high in cohort studies (31.15%). The prevalence of stunting among HIV positive children was found to be 51.63% in Ethiopia, followed by 48.21% in Uganda. ...

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Section: Methodsmentioning

confidence: 99%

“…The disagreement was resolved by the interference of a third reviewer. Studies were considered as high risk or poor quality, when it scored 3 and below [ 20 – 22 ] ( S2 Table ).…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Magnitude of underweight, wasting and stunting among HIV positive children in East Africa: A systematic review and meta-analysis

2020

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“…A recent systematic review including 20,911 participants from 12 studies indicated a 57.2% prevalence of neonatal hypothermia in Eastern Africa 5 . Of note, hypothermia in low-resource settings involves both term and preterm infants 5,6 . In low-middle resource settings, neonatal hypothermia was associated with elevated mortality risk in both hospital and community studies [7][8][9][10][11][12] .…”

mentioning

confidence: 99%

Non-linear association between admission temperature and neonatal mortality in a low-resource setting

Cavallin¹,

Calgaro

Brugnolaro

et al. 2020

Sci Rep

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Both neonatal hypothermia and hyperthermia represent important risk factors for neonatal mortality, but information on mortality risk across a full range of neonatal temperatures is lacking in low-resource settings. We evaluated the association between neonatal mortality and a full range of admission temperatures in a low-resource setting. This retrospective observational study was conducted at Beira Central Hospital, Mozambique. The relationship between admission temperature and mortality was evaluated using multivariable analyses with temperature modeled as non-linear term. Among 2098 neonates admitted to the Special Care Unit between January–December 2017, admission temperature was available in 1344 neonates (64%) who were included in the analysis. A non-linear association between mortality rate and temperature was identified. Mortality rate decreased from 84% at 32 °C to 64% at 34.6 °C (− 8% per °C), to 41% at 36 °C (− 16% per °C), to 26% to 36.6 °C (− 25% per °C) and to 22% at 38.3 °C (− 2% per °C), then increased to 40% at 41 °C (+ 7% per °C). Mortality rate was estimated to be at minimum at admission temperature of 37.5 °C. In conclusions, the non-linear relationship highlighted different mortality risks across a full range of neonatal temperatures in a low-resource setting. Admission temperature was not recorded in one third of neonates.

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Maintaining normal temperature immediately after birth in late preterm and term infants: A systematic review and meta-analysis

Ramaswamy¹,

Almeida²,

Dawson³

et al. 2022

Resuscitation

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Prevalence of neonatal hypothermia and its associated factors in East Africa: a systematic review and meta-analysis

Cited by 35 publications

References 34 publications

Magnitude of underweight, wasting and stunting among HIV positive children in East Africa: A systematic review and meta-analysis

Magnitude of underweight, wasting and stunting among HIV positive children in East Africa: A systematic review and meta-analysis

Non-linear association between admission temperature and neonatal mortality in a low-resource setting

Maintaining normal temperature immediately after birth in late preterm and term infants: A systematic review and meta-analysis

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