Prevalence of Neural Tube Defects: Moroccan Study 2008-2011

Radouani, Mohammed Amine; Chahid, Naima; Benmiloud, Loubna; Ammari, Leila El; Kharbach, Aicha; Rjimati, Larbi; Acharrai, Laila; Lahlou, K.; Aguenaou, Hassan; Barkat, Amina

doi:10.4236/ojped.2015.53038

Cited by 28 publications

(7 citation statements)

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“…38 39 Studies conducted in Morocco, Tunisia, Algeria, the Democratic Republic (DR) of Congo, Egypt, Cameron, Ghana and Libya were also identified. [42][43][44][45][46][47][48][49] All studies included in this review were facility-based studies, published in the year between 1992 and 2020. South Africa (started fortification in 2003), Nigeria (in 2002), Tanzania (in 2011) and Kenya (in 2012) have mandatory folic acid fortification with Wheat Flour and Maize Flour.…”

Section: Characteristics Of the Original Studiesmentioning

confidence: 99%

Birth prevalence of encephalocele in Africa: a systematic review and meta-analysis

Oumer

Kassahun

2021

bmjpo

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ObjectiveTo identify the birth prevalence of encephalocele in Africa, 2020.MethodsWe carried out a systematic search of the following databases (PubMed/Medline, PubMed Central, Joanna Briggs Institute (JBI) Library, Cochrane Library, Web of Science, Google Scholar, Science Direct, African Journals Online and Embase), using search terms (prevalence, encephalocele, “neural tube defects”, “cranium bifidum”, “congenital malformations”, “congenital defects”, “structural birth defects”, “structural abnormalities”, newborns/neonates/ “live births”/ “stillbirths” and their MeSH Terms) up to 16 July 2021. The JBI quality appraisal checklist was used to assess the quality of studies when they were abstracted using a standardised data extraction template. The I2 statistic and Cochrane Q test were used to examine heterogeneity across studies statistically. The prevalence of encephalocele was estimated using a random-effect meta-analysis model. Subgroup, sensitivity, meta-regression and time trend analysis were carried out. The publication bias was checked using Egger and Begg’s tests.ResultsTwenty-seven relevant studies were identified and provided a total of 5 107 109 births. In this systematic review and meta-analysis, the pooled birth prevalence of encephalocele in Africa was 0.02% (or 2 per 10 000 births) (95% CI 0.02% to 0.03%). The overall prevalence of birth encephalocele using the median from studies was 0.02% (IQR=0.01%–0.04%). Higher prevalence of encephalocele was detected in Nigeria 0.06% (95% CI 0.04% to 0.08%), Sudan 0.04% (95% CI 0.03% to 0.05%), Egypt 0.04% (95% CI 0.04% to 0.05%), DR of Congo 0.02% (95% CI 0.02% to 0.03%), Ethiopia 0.02% (95% CI −0.004% to 0.05%) and Tanzania 0.02% (95% CI 0.002% to 0.04%). The prevalence of encephalocele per live birth was 0.03% and both live birth and stillbirth was 0.03%.ConclusionsThis review indicates a high prevalence of encephalocele, but studies were limited suggesting the need for additional research.PROSPERO registration numberCRD42021242161.

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Section: Characteristics Of the Original Studiesmentioning

confidence: 99%

Birth prevalence of encephalocele in Africa: a systematic review and meta-analysis

Oumer

Kassahun

2021

bmjpo

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“…All research published between 1982 and 2022 that meet the criteria were eligible. There were forty cross-sectional studies (68.97%) [ 8 – 10 , 14 – 18 , 23 , 24 , 26 , 27 , 31 – 37 , 40 – 44 , 47 – 49 , 52 , 57 – 63 , 65 – 68 ], eight cohort studies (13.79%) [ 17 , 29 , 38 , 39 , 46 , 55 , 56 , 64 ], and ten case-control studies (17.24%) [ 19 – 22 , 28 , 30 , 32 , 50 , 51 , 54 ] in this analysis. Furthermore, 19 (32.76%) of the studies were rated as high quality.…”

Section: Resultsmentioning

confidence: 99%

Burden of Neural Tube Defects and Their Associated Factors in Africa: A Systematic Review and Meta-Analysis

Wakoya,

Afework

2023

International Journal of Pediatrics

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Background. Neural tube defects are a type of congenital anomaly caused by an abnormality in the development of the brain and spinal cord during embryogenesis. They cause high rates of mortality, morbidity, and lifelong disability. There are several studies carried out worldwide reporting different findings on the burden and associated factors. The aim of this study is to carry out a systematic review and meta-analysis of the burden of neural tube defects and their associated factors in Africa. Methods. A total of 58 eligible articles were identified systematically using databases such as PubMed, Embase, African Journal Online Library, ProQuest, Cochrane, Google Scopus, Google Scholar, and Grey literature. Extracted data were analyzed using STATA 16.0 statistical software. The heterogeneity of studies was determined using the Cochrane Q test statistic and I 2 test statistics with forest plots. A random effects model was used to examine the pooled burden of neural tube defects, subgroups of the region, subtypes of NTDs, sensitivity analysis, and publication bias. The association between NTDs and associated factors was studied using a fixed-effect model. Results. Fifty-eight studies with a total of 7,150,654 participants in 16 African countries revealed that the pooled burden of neural tube defects was 32.95 per 10,000 births (95% CI: 29.77-36.13). The Eastern African region had the highest burden in the subgroup analysis, with 111.13 per 10,000 births (95% CI: 91.85–130.42). South African countries had the lowest burden, at 11.43 per 10,000 births (95% CI: 7.51–15.34). In subtype analysis, spina bifida had the highest pooled burden at 17.01 per 10,000 births (95 percent CI: 15.00-19.00), while encephalocele had the lowest at 1.66 per 10,000 births (95% CI: 1.12-2.20). Maternal folic acid supplementation (AOR: 0.38; 95% CI: 0.16-0.94), alcohol consumption (AOR: 2.54; 95% CI: 1.08-5.96), maternal age (AOR: 3.54; 95% CI: 1.67-7.47), pesticide exposure (AOR: 2.69; 95% CI: 1.62-4.46), X-ray radiation (AOR: 2.67; 95% CI: 1.05-6.78), and history of stillbirth (AOR: 3.18; 95% CI: 1.11-9.12) were significantly associated with NTDs. Conclusion. The pooled burden of NTDs in Africa was found to be high. Maternal age, alcohol consumption, pesticide and X-ray radiation exposure, history of stillbirth, and folic acid supplementation were significantly associated with NTDs.

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“…However, this multicenter study excluded stillbirths, fetal deaths in utero after 22 weeks' amenorrhea, and medical terminations of pregnancy. Other local Moroccan studies have shown that the annual prevalence of NTDs [ 30 ] has decreased significantly, from 2.17 in 2008 to 1.21/1000 births in 2011. In 2021, another Moroccan study [ 31 ] showed that the prevalence rate of NTDs was 1 per 1000 LBs in Rabat.…”

Section: Discussionmentioning

confidence: 99%

Congenital Malformations in the Moroccan Surveillance System: Contribution to Prevalence Estimation

Kannane,

Boussaa,

Mendili

et al. 2024

Global Health, Epidemiology and Genomics

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Background. Congenital malformations (CMs) are a group of structural or functional anomalies present at birth. These anomalies result in a high rate of mortality, morbidity, and disability in children. CMs are a major public health problem and place a heavy burden on healthcare systems in both developed and developing countries including Morocco, which has had a CMs surveillance system in place since 2011. The aim of this study is to determine the prevalence of CMs in Morocco. Methods. In this study, the epidemiology of CMs in Morocco was assessed retrospectively using the national surveillance system data gathered from case notification forms from 2017 to 2021. Results. The main results showed that the prevalence of CMs in Morocco is 3.91/1000 live births (LBs), and the minimum annual prevalence of CMs was reached in 2017 (3.10/1000 LBs) while the maximum annual prevalence was recorded in 2018 (4.55/1000 LBs). The majority of CMs are unspecified CMs (68.55%), neural tube defects (NTDs) account for (21.13%), and orofacial clefts (OFCs) account for (10.32%). In addition, the majority of CMs (61.73%) were from rural areas. According to region, the Dakhla-Oued Eddahab region recorded the highest prevalence of CMs in Morocco, with 8.81/1000 LBs, while the lowest prevalence was recorded in the Rabat-Sale-Kenitra region, with 2.02/1000 LB. Conclusions. This study reveals that the national prevalence of CMs is high and may be underestimated, as most of the CMS reported is unspecified. The use of a CM registry with detailed reporting of all CMs and the promotion of preventive measures are urgently recommended.

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Prevalence of Neural Tube Defects: Moroccan Study 2008-2011

Cited by 28 publications

References 10 publications

Birth prevalence of encephalocele in Africa: a systematic review and meta-analysis

Birth prevalence of encephalocele in Africa: a systematic review and meta-analysis

Burden of Neural Tube Defects and Their Associated Factors in Africa: A Systematic Review and Meta-Analysis

Congenital Malformations in the Moroccan Surveillance System: Contribution to Prevalence Estimation

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