Prevalence of Neuropsychiatric Symptoms in Alzheimers Disease and Vascular Dementia

Fernández-Martı́nez, Manuel; Castro, Jéssica; Molano, Ana; Zarranz, J.J.; Rodrigo, Rosa Mónica; Ortega, Rafael

doi:10.2174/156720508783884585

Cited by 66 publications

(52 citation statements)

References 59 publications

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“…Summarizing, considering different findings of the two factor analyses and that different neurodegenerative diseases, such as AD VaD and FTD, are associated with different BPSD profiles [4,8,9], it must be underlined and suggested that BPSD clustering within the same neurodegenerative disease probably provides more clinically relevant information. …”

Section: Discussionmentioning

confidence: 99%

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Behavioral and Psychological Symptoms of Dementia: Factor Analysis and Relationship with Cognitive Impairment

Poletti

Nuti²,

Cipriani³

et al. 2012

Eur Neurol

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Background/Aims: Behavioral and psychological symptoms of dementia (BPSD) affect almost all people with dementia at some stage during the progression of disease. The current study aimed at replicating previous findings on BPSD clustering in behavioral sub-syndromes. Methods: One hundred and sixty-six consecutive outpatients with dementia attending a dementia outpatient clinic were enrolled and evaluated with the Neuropsychiatric Inventory and the Mini Mental State Examination. Results: BPSD were reported in 157 patients included in the final sample: 140 patients (89.17%) had Alzheimer’s disease (AD), while 17 patients had frontotemporal dementia or vascular dementia. The most frequent BPSD were depression in the whole sample and irritability in the AD subgroup. The severity of cognitive impairment was predicted by two BPSD in the whole sample (apathy and motor disturbance) and only by nighttime behavior in the AD subgroup. Factor analyses identified 4 factors, accounting for about 60% of variance in the whole group and in the AD subgroup of patients. Conclusions: The current study confirmed findings of previous studies on BPSD clustering, regarding the number of BPSD clusters and the total variance explained. This study has some limitations, including the small number of non-ADs and its monocentric character.

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Section: Discussionmentioning

confidence: 99%

“…Distinct neurodegenerative diseases may be associated with different BPSD profiles: apathy, sleep disturbances, appetite changes and aberrant motor behaviors are more common in vascular dementia (VaD) and Alzheimer’s disease (AD) [8,9], and agitation and disinhibition are more common in frontotemporal dementia (FTD) [4]. …”

Section: Introductionmentioning

confidence: 99%

Behavioral and Psychological Symptoms of Dementia: Factor Analysis and Relationship with Cognitive Impairment

Poletti

Nuti²,

Cipriani³

et al. 2012

Eur Neurol

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“…They are reported to be present in up to 96.4% of patients [21]. In AD, vascular risk factors, particularly hypertension and stroke, have been associated with an increased risk of neuropsychiatric symptoms [22].…”

Section: Dm and Neuropsychiatric Symptoms Of Dementiamentioning

confidence: 99%

Does Diabetes Mellitus Alter the Onset and Clinical Course of Vascular Dementia?

Murthy

Jawaid

Qureshi

et al. 2010

Behavioural Neurology

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Abstract. Background: Vascular dementia (VaD) is the second most common dementing illness. Multiple risk factors are associated with VaD, but the individual contribution of each to disease onset and progression is unclear. We examined the relationship between diabetes mellitus type 2 (DM) and the clinical variables of VaD. Methods: Data from 593 patients evaluated between June, 2003 and June, 2008 for cognitive impairment were prospectively entered into a database. We retrospectively reviewed the charts of 63 patients who fit the NINDS-AIREN criteria for VaD. The patients were divided into those with DM (VaD-DM, n = 29) and those without DM (VaD, n = 34). The groups were compared with regard to multiple variables. Results: Patients with DM had a significantly earlier onset of VaD (71.9 ± 6.54 vs. 77.2 ± 6.03, p < 0.001), a faster rate of decline per year on the mini mental state examination (MMSE; 3.60 ± 1.82 vs. 2.54 ± 1.60 points, p = 0.02), and a greater prevalence of neuropsychiatric symptoms at the time of diagnosis (62% vs. 21%, p = 0.02). Conclusions: A history of pre-morbid DM was associated with an earlier onset and faster cognitive deterioration in VaD. Moreover, DM was associated with neuropsychiatric symptoms in patients with VaD. A larger study is needed to verify these associations. It will be important to investigate whether better glycemic control will mitigate the potential effects of DM on VaD.

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“…In terms of differences between patients with VaD and AD, inconsistent findings have been reported. Some studies found that patients with AD and VaD had similar overall prevalence and profiles of neuropsychiatric symptoms [4,5]. In contrast, some studies found that patients with VaD had more depressive symptoms, anxiety, and psychiatric symptoms than those with AD [6,7,8,9], but another study found that AD patients had more delusions, hallucinations, anxieties, and phobias [10].…”

Section: Introductionmentioning

confidence: 99%

Health-Related Quality of Life and Self-Efficacy of Managing Behavior Problems for Family Caregivers of Vascular Dementia and Alzheimer's Disease Patients

Kuo

Huang

Hsu

et al. 2014

Dement Geriatr Cogn Disord

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Background: Little is known about the differences in patients' behavioral problems and health outcomes of family caregivers of patients with vascular dementia (VaD) and Alzheimer's disease (AD). Methods: A secondary analysis of baseline data on a subsample of caregiver-dementia patient dyads in a randomized clinical trial. Results: Family caregivers of VaD patients reported higher self-efficacy than caregivers of AD patients in handling verbally nonaggressive and verbally aggressive behaviors. Caregivers of VaD patients had poorer health-related quality of life (HRQoL) than caregivers of AD patients considering role disability due to physical health problems, bodily pain, social function, and physical component summary. Greater self-efficacy was associated with better mental health-related outcomes for family caregivers of VaD patients, and better self-care ability of VaD patients was associated with better caregiver mental health-related outcomes. Caring for a patient with more severe dementia predicted poor physical health-related outcomes in role disability due to physical health problems, but better overall mental health (mental component summary) for caregivers. Conclusion: This study is the first to examine and compare the behavioral problems of AD and VaD patients in a Chinese population, along with their family caregivers' self-efficacy and health outcomes. Family caregivers of patients with VaD might warrant specific attention to their HRQoL, with interventions developed to enhance their self-efficacy.

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Prevalence of Neuropsychiatric Symptoms in Alzheimers Disease and Vascular Dementia

Abstract: There were no significant differences between AD and VaD patients, except that sleep disturbances, appetite changes and aberrant motor behaviour that were more prevalent and severe in AD.

Cited by 66 publications

References 59 publications

Behavioral and Psychological Symptoms of Dementia: Factor Analysis and Relationship with Cognitive Impairment

Behavioral and Psychological Symptoms of Dementia: Factor Analysis and Relationship with Cognitive Impairment

Does Diabetes Mellitus Alter the Onset and Clinical Course of Vascular Dementia?

Health-Related Quality of Life and Self-Efficacy of Managing Behavior Problems for Family Caregivers of Vascular Dementia and Alzheimer's Disease Patients

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