Prevalence of Neuropsychiatric Symptoms in Young-Onset Compared to Late-Onset Alzheimer’s Disease – Part 1: Findings of the Two-Year Longitudinal NeedYD-Study

Vliet, Deliane van; Vugt, Marjolein E. de; Aalten, Pauline; Bakker, Christian; Pijnenburg, Yolande A.L.; Vernooij‐Dassen, Myrra; Koopmans, Raymond T.C.M.; Verhey, Frans R.J.

doi:10.1159/000342824

Cited by 61 publications

(69 citation statements)

References 55 publications

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“…Moreover, they found fewer delusions and hallucinations as well as less agitation, disinhibition, and aberrant motor behavior in YO-AD than in LO-AD. van Vliet et al (2012) also found lower incidence and prevalence rates of NPS in community-dwelling people with YO-AD than in those with LO-AD. In addition, Mushtaq et al (2016) found higher levels of delusions, agitation, anxiety, disinhibition and nighttime behavioral disturbances in community-dwelling people with LO-AD than in those with YO-AD.…”

Section: Introductionmentioning

confidence: 68%

Differences in neuropsychiatric symptoms between nursing home residents with young-onset dementia and late-onset dementia

Appelhof

Bakker

IJssel

et al. 2018

Aging & Mental Health

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Objective: The aims of the current study are (1) to explore the differences in neuropsychiatric symptoms (NPS) between young-onset dementia (YOD) and late-onset dementia (LOD), and (2) to investigate whether the possible differences can be attributed to differences in dementia subtype, gender, psychotropic drug use (PDU), or dementia severity. Method: Three hundred and eighty-six nursing home (NH) residents with YOD and 350 with LOD were included. Multilevel modeling was used to compare NPS between the groups . Furthermore, dementia subtype, gender, PDU, and dementia severity were added to the crude multilevel models to investigate whether the possible differences in NPS could be attributed to these characteristics. Results: Higher levels of apathy were found in NH residents with YOD. After the characteristics were added to the models, also lower levels of verbally agitated behaviors were found in YOD . Conclusion: We recommend that special attention be paid to interventions targeting apathy in YOD. Although no differences in other NPS were found, the PDU rates were higher in YOD, suggesting that the threshold for the use of PDU in the management of NPS is lower. This underscores the need for appropriate attention to non-pharmacological interventions for the management of NPS in YOD.

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Section: Introductionmentioning

confidence: 68%

Differences in neuropsychiatric symptoms between nursing home residents with young-onset dementia and late-onset dementia

Appelhof

Bakker

IJssel

et al. 2018

Aging & Mental Health

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“…The development of YOD and receiving the dementia diagnosis are reasonably followed by anxiety, turmoil, depression (Haugen, 2012; Johannessen & Möller, 2013), reduced quality of life and increased problems in everyday life in relation to work, friends and family (Spreadbury & Kipps, 2017). Behaviour will change, and behavioural changes are more frequent in YOD than in people with late-onset dementia (LOD; van Vliet et al, 2012). Usually, people with YOD are diagnosed at a later stage of the disease compared to people with LOD (Harvey et al, 2003; Koedam et al, 2008; Luscombe et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

“To be, or not to be”: experiencing deterioration among people with young-onset dementia living alone

Johannessen

Engedal

Haugen

et al. 2018

International Journal of Qualitative Studies on Health and Well

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Having dementia before the age of 65 (YOD) represents a radical break from an age-normative and expected life course. The disease afflicts the person’s identity, threatens the self-image and self-confidence, and erodes the person’s plans. The aim of the study was toexamine how people living alone with YOD perceive the course of dementia, their needs, and coping strategies, with a focus on narrating everyday life experiences. A longitudinal study using a qualitative approach was used. Five interviews, each with 10 informants, took place every 6 months from 2014 to 2017. The main theme is the person’s experiences of changes of identity over time. The most significant aspects of their experiences of the dementia affecting them and their reactions are these: the initial signs, coping efforts, concealing the diagnosis, social retraction, existential anxiety, revival of the self, worse and worse, and health personnel as background. The study concluded thatpeople with dementia are able to describe their experiences and needs for a long time during the progression of dementia. Their voices should be listened to for planning of services. Personalized care should be used to support them in order to preserve their identity in a normalized everyday life as far as possible.

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“…Two studies found QOL in community-dwelling people with YOD to be associated with depressive symptoms [39, 40]. A Dutch study found a generally low prevalence of NPS in young-onset AD compared to late-onset AD during a 2-year follow-up [41]. In nursing home residents, Appelhof et al [42] found a significant association between NPS and psychotropic drug use and QOL.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in People with Young-Onset Alzheimer’s Dementia and Frontotemporal Dementia

Hvidsten

Engedal

Selbæk

et al. 2018

Dement Geriatr Cogn Disord

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Aims: The aims of this study were to compare quality of life (QOL) in people with young-onset Alzheimer’s (AD) and frontotemporal (FTD) dementia, explore variables associated with QOL, and compare QOL in young-onset dementia (YOD) and late-onset dementia (LOD). Methods: Cross-sectional data from a Nordic multicenter study of 50 community-dwelling participants with AD and 38 with FTD were included. A comparison group consisted of 100 people with LOD. QOL was measured using self-reported Euro-QOL 5-Dimension and the proxy version of Quality of Life in Alzheimer’s Disease (QOL-AD) questionnaire. Neuropsychiatric symptoms and needs were assessed using the Cornell Scale for Depression in Dementia (CSDD), Neuropsychiatric Inventory (NPI), and Camberwell Assessment of Needs in the Elderly. Multiple linear regression and multilevel modeling was used to determine variables associated with QOL. Results: We found no differences between the two YOD groups in QOL. The variables associated with QOL were scores on the CSDD, NPI, and unmet needs. The proxy QOL-AD score in YOD was significantly higher compared to LOD (median 36.0 [IQR 10.0] vs. 33.0 [IQR 9.0]). Conclusion: The QOL in Nordic people with YOD was better compared to people with LOD. Our results show depressive symptoms to be associated with QOL irrespective of age and diagnosis.

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Prevalence of Neuropsychiatric Symptoms in Young-Onset Compared to Late-Onset Alzheimer’s Disease – Part 1: Findings of the Two-Year Longitudinal NeedYD-Study

Cited by 61 publications

References 55 publications

Differences in neuropsychiatric symptoms between nursing home residents with young-onset dementia and late-onset dementia

Differences in neuropsychiatric symptoms between nursing home residents with young-onset dementia and late-onset dementia

“To be, or not to be”: experiencing deterioration among people with young-onset dementia living alone

Quality of Life in People with Young-Onset Alzheimer’s Dementia and Frontotemporal Dementia

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