Prevalence of non-Alcoholic Fatty Liver Disease and Associated Factors in Patients with Moderate or Severe Hemophilia: A Multicenter-Based Study

Shen, Ming‐Ching; Chiou, Shyh‐Shin; Chou, Sheng-Chieh; Weng, Te‐Fu; Lin, Chung‐Sheng; Wang, Jiaan-Der; Lee, Shou-Wu; Peng, Ching‐Tien

doi:10.1177/10760296221128294

Cited by 7 publications

(3 citation statements)

References 39 publications

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“… 11 , 33 Accordingly, 38% and 8% of patients in our series were overweight and obese, respectively, which increases the risk of diabetes, dyslipidemia, arterial hypertension, and, ultimately, NAFLD, which is the liver expression of the metabolic syndrome. 33 , 34 We also found that, although the vast majority had a minimal to moderate alcohol intake, 12% of the whole cohort were heavy drinkers (≥14 AUs per week), which is a risk factor for such systemic complications as chronic hepatitis/cirrhosis. 31 , 35 …”

Section: Discussionmentioning

confidence: 67%

Residual burden of liver disease after HCV clearance in hemophilia: a word of caution in the era of gene therapy

La Mura,

Bitto,

Capelli

et al. 2023

Blood Advances

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Ruling out advanced fibrosis/cirrhosis is mandatory for persons with hemophilia (PWH) who are candidate to gene therapy. However, clinical evaluation and non-invasive tests may be inaccurate after HCV clearance. We conducted a prospective hepatological screening to detect advanced fibrosis/cirrhosis in PWH after HCV clearance. Any risk factor of chronic liver damage was registered by using biochemical data, liver stiffness measurement (LSM) and ultrasound (US). A pre/post HCV clearance analysis was prospectively conducted in a subgroup of patients with the measurement of LSM, US and non-invasive tests of fibrosis (NITs). We evaluated 119 patients (median age: 53 years; range: 36-87) with a previous HCV infection (108/11 hemophilia A/B). Ninety-six (81%) presented at least one potential risk factor of chronic liver damage. Metabolic risk factors were the most prevalent, 51 cases (44%) having US steatosis. In 21 cases (18%) clinical, biochemical, liver morphology and/or LSM were suggestive of advanced fibrosis/cirrhosis. Furthermore, 10 cases (8%) had esophageal varices, 3(3%) hepatocellular carcinoma. In 57 cases included in the prospective analysis, LSM and NITs were reduced after HCV-clearance (p<0.05), but US signs specific of cirrhosis remained unchanged. Overall, 23/80(29%) cases with LSM<10KPa had at least one US sign suggestive of advanced fibrosis/cirrhosis. A similar proportion (18%) was observed for LSM<8KPa. Overall, risk factors of chronic liver damage are frequent after HCV clearance, but LSM and NITs changes after clearance may be inaccurate to rule out advanced fibrosis/cirrhosis. A specific diagnostic work-up is warranted to evaluate liver health in PWH in the era of gene therapy.

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Section: Discussionmentioning

confidence: 67%

Residual burden of liver disease after HCV clearance in hemophilia: a word of caution in the era of gene therapy

La Mura,

Bitto,

Capelli

et al. 2023

Blood Advances

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“…Although the exact root cause of the increase in FVIII levels in liver diseases is not known, there are several hypotheses regarding why FVIII levels changed [ 175 , 176 , 177 ]. The release of cytokine from necrotic cirrhotic liver tissue might result in elevated FVIII synthesis [ 178 ].…”

Section: Possible Interaction Mechanisms Among Coagulation Dyshomeost...mentioning

confidence: 99%

Coagulation Dysfunctions in Non-Alcoholic Fatty Liver Disease—Oxidative Stress and Inflammation Relevance

Robea,

Balmus,

Girleanu

et al. 2023

Medicina

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Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases. Its incidence is progressively rising and it is possibly becoming a worldwide epidemic. NAFLD encompasses a spectrum of diseases accounting for the chronic accumulation of fat within the hepatocytes due to various causes, excluding excessive alcohol consumption. In this study, we aimed to focus on finding evidence regarding the implications of oxidative stress and inflammatory processes that form the multifaceted pathophysiological tableau in relation to thrombotic events that co-occur in NAFLD and associated chronic liver diseases. Recent evidence on the pathophysiology of NAFLD suggests that a complex pattern of multidirectional components, such as prooxidative, proinflammatory, and prothrombotic components, better explains the multiple factors that promote the mechanisms underlying the fatty acid excess and subsequent processes. As there is extensive evidence on the multi-component nature of NAFLD pathophysiology, further studies could address the complex interactions that underlie the development and progression of the disease. Therefore, this study aimed to describe possible pathophysiological mechanisms connecting the molecular impairments with the various clinical manifestations, focusing especially on the interactions among oxidative stress, inflammation, and coagulation dysfunctions. Thus, we described the possible bidirectional modulation among coagulation homeostasis, oxidative stress, and inflammation that occurs in the various stages of NAFLD.

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“…NAFLD, like other chronic liver illnesses, causes some individuals' fibrosis to worsen, which then causes cirrhosis and accompanying complications. 4 The majority of individuals can die from cardiovascular disease and metabolic syndrome since NAFLD and metabolic syndrome are closely related. In wealthy nations, obesity and NAFLD are widespread problems.…”

Section: Introductionmentioning

confidence: 99%

Association of Triglyceride-Glucose Index and Liver Function Parameters Among Healthy Obese Civil Servants: A Center-Based Study

Pan¹,

Yue²,

Ren³

et al. 2022

DMSO

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To investigate the correlation between Triglyceride-glucose (TyG) index and liver function parameters in healthy obese civil servants in Shijiazhuang, China. Materials and Methods: This was an outpatient-based cross-sectional study in which 6452 participants were recruited. A total of 784 participants were analyzed according to inclusion and exclusion criteria. A TyG index was calculated based on fasting glucose and triglycerides. All patients were divided into a high TyG index group and a low TyG index group, using the median TyG index as a cutoff. Finally, patients were further divided into two subgroups: males and females. Results: While AST/ALT and direct bilirubin levels were lower in the high TyG index group compared to the low TyG index group, ALT, AST, total protein, and albumin levels were greater. Particularly in male participants, TyG index was inversely connected with AST/ALT and direct bilirubin levels and favorably correlated with ALT, AST, total protein, and albumin levels. These connections persisted in the multilinear regression study even after adjusting for confounding variables. Conclusion:This study describes the correlation between TyG index and liver function parameters in obese populations without comorbid diseases, providing a new idea for early interventional treatment in this group.

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Prevalence of non-Alcoholic Fatty Liver Disease and Associated Factors in Patients with Moderate or Severe Hemophilia: A Multicenter-Based Study

Cited by 7 publications

References 39 publications

Residual burden of liver disease after HCV clearance in hemophilia: a word of caution in the era of gene therapy

Residual burden of liver disease after HCV clearance in hemophilia: a word of caution in the era of gene therapy

Coagulation Dysfunctions in Non-Alcoholic Fatty Liver Disease—Oxidative Stress and Inflammation Relevance

Association of Triglyceride-Glucose Index and Liver Function Parameters Among Healthy Obese Civil Servants: A Center-Based Study

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