Prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus and its correlation with coronary artery disease (CAD)

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is a common association of Type 2 diabetes mellitus and diabetes mellitus is a leading risk factor for coronary artery disease (CAD). This study aims at estimating the prevalence of NAFLD by ultrasonography and to correlate NAFLD with CAD in a group of patients with Type 2 DM.Methods: Consecutive patients of Type 2 diabetes fulfilling the inclusion criteria were recruited. Clinical and biochemical parameters were recorded. NAFLD was diagnosed by ultrasonography.Results: The prevalence of NAFLD was 41.2% in the study group (n=114) and was higher in females. Prevalence of NAFLD in the younger age group was significantly higher than that in the older age group. Elevated liver enzymes, elevated HbA1C, duration of diabetes, obesity, acanthosis nigricans and metabolic syndrome were all significantly associated with NAFLD. CAD was significantly higher in the NAFLD subgroup (72.46%) compared to the non-NAFLD subgroup (52.63%) (p=0.001). Using binary logistic regression analysis, it was found that NAFLD is an independent predictor of CAD (p=0.002).Conclusions: NAFLD is extremely common in people with Type 2 diabetes and is associated with a higher prevalence of CAD.NAFLD is an independent risk factor for development of CAD. Thus, identification of NAFLD in diabetics might help in predicting the risk of CAD and to adopt the necessary preventive strategy.

A study of biochemical parameters in pregnant women in III trimester with non-alcoholic fatty liver disease (NAFLD)

“…on-alcoholic fatty liver disease (NAFLD) is a condition whereby there is excessive accumulation of triglycerides in the liver without excess alcohol consumption. India being the capital for diabetes mellitus in the world, the prevalence of NAFLD among general population is high with prevalence of 15-40% in western countries and 9-32% in India (1). Liver being a visceral organ with distinct porto-venous circulation releases free fatty acids directly into the portal venous system unlike subcutaneous, adipose tissue which releases in the general circulation (2).…”

Beetroot Supplementation on Non - Alcoholic Fatty Liver Disease Patients

“…2 The prevalence of NAFLD is estimated to be about 9 -32 % in general Indian population but the real prevalence of NAFLD is unknown due to under diagnosis. 3 Prevalence of NAFLD in different populations are estimated to be as follows; United States 30 % , Middle East 32 % , South America 30 % , Asia 27 % , Europe 24 % and Africa 13%. 1 It is not surprising that the prevalence of NAFLD in increasing every year worldwide due to dietary irresponsibility and predominance of sedentary lifestyle.…”

Study of the Frequency of Nonalcoholic Fatty Liver Disease (NAFLD) in Type 2 Diabetes Mellitus (DM) in a Tertiary Care Centre

“…Prevalence of NAFLD was significantly associated with HbA1c, duration of diabetes and obesity, these findings are comparable with our study. 14 17 There is a paucity of data regarding the incidence of NAFLD in the general population. We compared the prevalence and risk factors of NAFLD in the general population with present study.…”