Prevalence of non Helicobacter pylori gastric Helicobacters in Iranian dyspeptic patients

Shafaie, S.; Kaboosi, Hami; Ghadikolaii, Fatemeh Peyravii

doi:10.1186/s12876-020-01331-x

Cited by 12 publications

(9 citation statements)

References 34 publications

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“…All of the 50 patients in this study were almost asymptomatic, and were incidentally diagnosed as NHPH infection by gastric biopsy in a regular checkup EGD. Some previous studies have reported that NHPH was detected with high proportions in symptomatic patients 11 , 13 , 14 . However, the result of our study shows that, also in NHPH‐infected patients, the proportion of asymptomatic patients is likely to be greater than that of symptomatic patients as well as in H .…”

Section: Discussioncontrasting

confidence: 70%

“…Some previous studies have reported NHPH infection cases that had been asymptomatic and were unexpectedly found by EGD for regular health check 5,10 . On the other hand, NHPH is also reported to be associated with dyspeptic symptoms and parkinsonism 11–14 . Regarding MALT lymphoma, Stolte et al found it in 7 of 202 patients with NHPH gastritis, 15 and Okiyama et al found it in 4 of 15 patients with NHPH gastritis 16 …”

Section: Discussionmentioning

confidence: 99%

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Prevalence, clinical features, and esophagogastroduodenoscopy (EGD) findings of non‐Helicobacter pylori Helicobacter infection: A study of 50 cases at a single facility in Japan

Tsukadaira¹,

Hayashi²,

Ota

et al. 2021

Helicobacter

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Background and aim: There are only a few reports of non-Helicobacter pylori Helicobacter (NHPH) gastritis in Japanese patients. We aimed to examine its prevalence, clinical features, and esophagogastroduodenoscopy (EGD) findings based on 50 patients encountered in one facility. Materials and methods:Subjects were all patients who had undergone gastric mucosal biopsy endoscopically at Kenwakai Hospital for approximately 10 years. NHPH infection was diagnosed by microscopic findings of Giemsa staining performed on all specimens. PCR analysis of urease genes was performed to detect and identify NHPH, when informed consent was obtained. Helicobacter pylori-diagnostic tests were also performed. NHPH-infected patients were questioned about symptoms and animal contact.Results: NHPH gastritis was found in 50 of 3847 patients (1.30%). The percentage increased to 3.35% (30 of 896 patients) in the latter 2 years and 4 months with increasing recognition of its characteristic endoscopic findings by endoscopists. PCR analysis, performed in 30 patients, detected NHPH in 28 patients: 26 as Helicobacter suis and 2 as Helicobacter heilmanii/Helicobacter ailurogastricus. Helicobacter pylori-diagnostic tests were almost negative. However, anti-H. pylori antibody showed high-negative titer (3.0-9.9 U/ml) in 12. Of 50 patients (consisting of 49 men and 1 woman), almost all were asymptomatic, and 25 were keeping pets. Regarding EGD findings, in all 50 patients, "crack-like mucosa" and/or nodular gastritis was noted in gastric antrum, and regular arrangement of collecting venules (RAC) was noted in gastric corpus. None of the patients infected with NHPH were co-infected with H. pylori. Conclusions:The prevalence was finally estimated to be approximately 3.35%.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Prevalence, clinical features, and esophagogastroduodenoscopy (EGD) findings of non‐Helicobacter pylori Helicobacter infection: A study of 50 cases at a single facility in Japan

Tsukadaira¹,

Hayashi²,

Ota

et al. 2021

Helicobacter

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“…Two PCR assays were used for detection of H. pylori DNA, one targeting the ureAB gene and the other one targeting the glmM gene. Although a number of studies have been published diagnosing H. pylori infection based on a ureAB gene PCR only [ 19 , 37 , 38 ], some reports indeed claim that H. pylori identification should include these two different target genes amplification [ 39 – 41 ]. Lu et al compared five PCR methods for detection of H. pylori DNA of 24 culture-positive samples obtained from 50 human gastric samples, including PCRs targeting the ureA and glmM gene.…”

Section: Discussionmentioning

confidence: 99%

Molecular detection of Helicobacter spp. and Fusobacterium gastrosuis in pigs and wild boars and its association with gastric histopathological alterations

Nunes

Mateus

Taillieu

et al. 2022

Vet Res

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Besides Helicobacter pylori, a Gram-negative bacterium that may cause gastric disorders in humans, non-Helicobacter pylori helicobacters (NHPH) may also colonize the stomach of humans and animals. In pigs, H. suis can induce gastritis and may play a role in gastric ulcer disease, possibly in association with Fusobacterium gastrosuis. In the present study, gastric samples from 71 slaughtered pigs and 14 hunted free range wild boars were tested for the presence of DNA of F. gastrosuis and gastric Helicobacter species associated with pigs, dogs cats and humans, using species-specific PCR assays, followed by sequencing of the amplicon. These gastric samples were also histopathologically evaluated. Almost all the pigs presented gastritis (95.8%). Helicobacter spp. were detected in 78.9% and F. gastrosuis in 35.2% of the animals. H. suis was the most frequently identified Helicobacter species (57.7% of the animals), followed by a H. pylori-like species (50.7%) and less often H. salomonis and H. felis (each in 2.8% of the animals). H. suis was most often detected in the glandular (distal) part of the stomach (pars oesophagea 9.9%, oxyntic mucosa 35.2%, antral mucosa 40.8%), while the H. pylori-like species was mainly found in the non-glandular (proximal) part of the stomach (pars oesophagea 39.4%, oxyntic mucosa 14.1%, antral mucosa 4.2%). The great majority of wild boars were also affected with gastritis (71.4%) and Helicobacter spp. and F. gastrosuis were detected in 64.3% and 42.9% of the animals, respectively. H. bizzozeronii and H. salomonis were the most frequently detected Helicobacter species, while a H. pylori-like species and H. suis were only occasionally identified. These findings suggest that these microorganisms can colonize the stomach of both porcine species and may be associated with gastric pathology. This should, however, be confirmed through bacterial isolation. This is the first description of the presence of F. gastrosuis DNA in the stomach of wild boars and a H. pylori-like species in the pars oesophagea of the porcine stomach.

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“…In addition, cases of bacteraemia of non- H. pylori Helicobacter species have been reported 483 484. Multiple non- H. pylori Helicobacter species have been linked with various gastric conditions in patient cohorts, case series or case reports including dyspepsia,485 gastritis,486 487 peptic ulcer disease,488 489 gastric cancer490 and gastric mucosa-associated lymphoid tissue lymphoma 491 492. In addition, numerous case reports have been published revealing associations with gastroenteritis 493 494.…”

Section: Wg 5: Helicobacter Pylori and The Gut Microbiotamentioning

confidence: 99%

Management ofHelicobacter pyloriinfection: the Maastricht VI/Florence consensus report

Malfertheiner

Mégraud

Rokkas

et al. 2022

Gut

688

842

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Helicobacter pyloriInfection is formally recognised as an infectious disease, an entity that is now included in the International Classification of Diseases 11th Revision. This in principle leads to the recommendation that all infected patients should receive treatment. In the context of the wide clinical spectrum associated with Helicobacter pylori gastritis, specific issues persist and require regular updates for optimised management.The identification of distinct clinical scenarios, proper testing and adoption of effective strategies for prevention of gastric cancer and other complications are addressed. H. pylori treatment is challenged by the continuously rising antibiotic resistance and demands for susceptibility testing with consideration of novel molecular technologies and careful selection of first line and rescue therapies. The role of H. pylori and antibiotic therapies and their impact on the gut microbiota are also considered.Progress made in the management of H. pylori infection is covered in the present sixth edition of the Maastricht/Florence 2021 Consensus Report, key aspects related to the clinical role of H. pylori infection were re-evaluated and updated. Forty-one experts from 29 countries representing a global community, examined the new data related to H. pylori infection in five working groups: (1) indications/associations, (2) diagnosis, (3) treatment, (4) prevention/gastric cancer and (5) H. pylori and the gut microbiota. The results of the individual working groups were presented for a final consensus voting that included all participants. Recommendations are provided on the basis of the best available evidence and relevance to the management of H. pylori infection in various clinical fields.

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Prevalence of non Helicobacter pylori gastric Helicobacters in Iranian dyspeptic patients

Cited by 12 publications

References 34 publications

Prevalence, clinical features, and esophagogastroduodenoscopy (EGD) findings of non‐Helicobacter pylori Helicobacter infection: A study of 50 cases at a single facility in Japan

Prevalence, clinical features, and esophagogastroduodenoscopy (EGD) findings of non‐Helicobacter pylori Helicobacter infection: A study of 50 cases at a single facility in Japan

Molecular detection of Helicobacter spp. and Fusobacterium gastrosuis in pigs and wild boars and its association with gastric histopathological alterations

Management ofHelicobacter pyloriinfection: the Maastricht VI/Florence consensus report

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