2014
DOI: 10.1016/j.ihj.2014.08.006
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Prevalence of nonalcoholic fatty liver disease (NAFLD) in patients of cardiovascular diseases and its association with hs-CRP and TNF-α

Abstract: Our data indicates that NALD is highly prevalent in patients of cardiovascular disease (69.2%) and is significantly associated with metabolic syndrome and its individual components. The levels of hs-CRP and TNF-α were significantly higher in patients with NAFLD and showed an increasing trend with the severity of fatty liver.

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Cited by 54 publications
(41 citation statements)
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“…Although the remaining indirect effects of elevated liver fat are unmeasured in this study, the link between NAFLD and low-grade inflammation 18 makes it likely that this also underpins some of the observed relationship between liver fat and aortic stiffness. In line with this, C-reactive protein, interleukin-6 and tumor necrosis factor-α levels have all been found to correlate with both NAFLD and aortic stiffness.…”
Section: Hepatic Fat Content Inflammation and Aortic Stiffnessmentioning
confidence: 87%
“…Although the remaining indirect effects of elevated liver fat are unmeasured in this study, the link between NAFLD and low-grade inflammation 18 makes it likely that this also underpins some of the observed relationship between liver fat and aortic stiffness. In line with this, C-reactive protein, interleukin-6 and tumor necrosis factor-α levels have all been found to correlate with both NAFLD and aortic stiffness.…”
Section: Hepatic Fat Content Inflammation and Aortic Stiffnessmentioning
confidence: 87%
“…In contrast, we did not find any correlations between adhesive molecules and BMI or TNF-a and BMI. Strong correlations have been found between central adiposity and adhesive molecules ICAM-1 and VCAM-1 in obese subjects 40 and TNF-a with nonalcoholic fatty liver disease (NAFLD), 41 reinforcing the potential link between visceral adiposity and increased risk for heart disease. The lack of correlations between these molecules and BMI suggests that central obesity and NAFLD play a key role in the circulating pool of these inflammatory markers independent of BMI.…”
Section: Plasma Lipids and Lipoproteinsmentioning
confidence: 92%
“…Cell Culture-The NCTC1469 murine liver cell line (American Type Culture Collection) was cultured in low-glucose Dulbecco's modified Eagle's medium (L-DMEM) (Invitrogen) supplemented with 10% horse serum (HyClone), 100 units/ml penicillin (Invitrogen), and 0.1 mg/ml streptomycin (HyClone) at 37°C with humidified air and 5% CO 2 .…”
Section: Methodsmentioning
confidence: 99%
“…It is the most prevalent chronic liver disease worldwide and is strongly associated with various metabolic disorders, such as obesity, type 2 diabetes, and cardiovascular disease (1)(2)(3). The disease may progress to nonalcoholic steatohepatitis (NASH), hepatic fibrosis/cirrhosis, and hepatocellular carcinoma due to the co-existence of other detrimental factors (4,5).…”
mentioning
confidence: 99%