Prevalence of nutritional deficiencies in hair loss among Indian participants: Results of a cross-sectional study

Abstract

Background:Nutritional deficiencies are known to be associated with hair loss; however, the exact prevalence is not known.Aims:The aim of this study is to evaluate the prevalence of nutritional deficiencies in participants with hair loss.Materials and Methods:In this cross-sectional study, 100 enrolled participants were divided into telogen effluvium (TE), male-pattern hair loss (MPHL), and female-pattern hair loss (FPHL) based on the type of hair loss. All participants underwent laboratory estimation for micronutrients and amino acid levels.Results:Participants with hair loss showed varied amino acid and micronutrient deficiencies across all types of hair loss. Nutritional status did not vary much between the types of hair loss. Among the essential amino acids, histidine deficiency was seen in >90% of participants with androgenic alopecia and 77.78% of participants with TE while leucine deficiency was seen 98.15% of participants with TE and 100% with FPHL. Valine deficiency was also very common across alopecia subtypes. Among the nonessential amino acids, alanine deficiency was observed in 91.67% FPHL, 91.18% MPHL, and 90.74% TE. Cysteine deficiency was present in 55.58% and 50% of participants with MPHL and TE, respectively. A relatively higher proportion of participants with TE had iron deficiency compared to androgenic alopecia (P = 0.069). Zinc deficiency was seen in 11.76% of participants with MPHL while copper deficiency was seen in 29.41% and 31.48% of participants with MPHL and TE, respectively.Conclusion:Nutritional deficiency is a common problem in participants with hair loss irrespective of the type of alopecia. The findings of our study suggest need for identification and correction of nutritional deficiencies in patients with hair loss.

Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients after Finasteride Treatment for a Year

“…However, in previous studies, patients with alopecia had various amino acid deficiencies. In particular, histidine deficiencies among essential amino acids and alanine deficiencies among nonessential amino acids were found in over 90% of male pattern baldness patients [18]. Additionally, in our previous study, we confirmed that polyamines synthesized through arginine to agmatine are associated with pattern baldness in human hair samples [19,20].…”

The Role of Vitamins and Minerals in Hair Loss: A Review

“…In contrast to the study of Gowda et al [ 109 ], a study conducted by Deo et al in India aimed to detect the prevalence of several forms of hair loss in females and to correlate these data with levels of hemoglobin and serum ferritin. This observational study involved 135 subjects, the majority (62.2%) of whom had TE, with the next largest group having FPHL (23.7%).…”

“…Their results indicate that a relatively higher proportion of participants with TE (20.37%) had iron deficiency compared to those with FPHL (16.67%) and male pattern hair loss (MPHL) (2.94%) ( p = 0.069). Furthermore, transferrin saturation and ferritin levels were lower in patients with FPHL (41.67%) and TE (40.74%) than in patients with MPHL (11.76%) [ 109 ]. Iron deficiencies were found to be related to gender rather than to type of hair loss.…”

Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium

“…Similarly, the role of vitamin D has been much discussed in several pathologies, including TE; a study involving 80 women with TE demonstrated significantly lower levels in relation to the control group, although the mechanism of action has not yet been established. 21 …”