Prevalence of obesity in rheumatoid arthritis and its association with disease activity and latex positivity in a sample of patients in Erbil

Younis, Khadeeja Ramadhan; Al-Bustany, Dashty Abass

doi:10.15218/zjms.2017.027

Cited by 7 publications

(8 citation statements)

References 41 publications

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“…It is important to mention that no significant associations were found between BMI and RF anti-CCP in RA patients in the current study. The findings of the study of Younis and Al-Bustany [20] is in agreement with the results of this study. However, two previous studies observed that obesity is significantly associated with increased likelihood for development of anti-CCP-negative RA [26,27], meanwhile Lu et al found that risks of anti-CCP-positive and anti-CCPnegative RA were increased in overweight and obese females, especially those with early disease [28].…”

Section: Discussionsupporting

confidence: 92%

“…In agreement to the findings of this study, Levitsky et al reported that obesity was the strongest independent factor for prediction of non-remission among the RA patients despite the initiation of treat-to-target approach [23]. Also, study of Younis and Al-Bustany showed a positive association between obesity and disease activity since patients with higher BMI had higher DAS28 and also higher clinical disease activity index [20]. These findings are also consistent with those of Vidal et al [9] who reported that the DAS28 appeared to be higher in obese than in normal-weight RA patients.…”

Section: Discussionsupporting

confidence: 90%

“…Prevalence of overweight and obesity among the RA patients varied greatly among the studies. Younis and Al-Bustany showed that 80.0% of RA patients were overweight and obese (33.3% and 46.7%) [20]. Crowson et al reported that 40.3% of RA patients were obese [21].…”

Section: Discussionmentioning

confidence: 99%

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Impact of obesity on rheumatoid arthritis: Relation with disease activity, joint damage, functional impairment and response to therapy

OM¹,

AS²,

AE³

et al. 2018

Int. J. Clin. Rheumatol

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Background and Aim of Work: The impact of Body Mass Index (BMI) on outcomes of Rheumatoid Arthritis (RA) is uncertain. This study aimed to evaluate the influence of obesity on Egyptian patients with RA. Methods: Medical records of 146 RA patients were reviewed. Patients were categorized into normalweight, overweight and obese groups based on BMI. The clinical and laboratory indices of RA activity, the Health Assessment Questionnaire (HAQ) and the radiographic damage score were compared among the groups at baseline, 8, 16 and 24 months. Results: DAS28 and HAQ score were matched at baseline but improved in the 3 groups thereafter, however, differences among the groups become significant only at 24-month. At the 24-month, DAS28 was significantly better in normal-weight (2.1 ± 1.0) and in overweight groups (2.2 ± 0.8) compared to obese group (2.7 ± 1.0) (normal-weight vs obese p=0.003 and overweight vs obese p= 0.006). At the 24-month, HAQ score was significantly better in normal-weight (0.78 ± 0.6) and in overweight groups (0.82 ± 0.5) compared to obese group (1.09 ± 0.7) (normal-weight vs obese p= 0.16 and overweight vs obese p= 0.041). The radiological Sharp-van der Heijde Score along the study period was lower in obese than in overweight or normal-weight patients, albeit the differences in the radiological score were insignificant among the groups. Conclusion: Obese patients were shown to have a poorer response rate to treatment in all outcome measures in comparison to the overweight and the normal-weight RA patients. Future research work is required to investigate whether weight reduction can decrease non-remission rate among the obese RA patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

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Impact of obesity on rheumatoid arthritis: Relation with disease activity, joint damage, functional impairment and response to therapy

OM¹,

AS²,

AE³

et al. 2018

Int. J. Clin. Rheumatol

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“…This finding underlines the role that obesity plays in inflammation, autoimmune conditions, and metabolic disease 13 . On the other hand, obesity is common among RA patients, which is associated with higher disease activity 14 . Being female increased the risk of obesity, as we found in our results.…”

Section: Discussionsupporting

confidence: 82%

Cardiovascular risk factors among Jordanian patients with rheumatoid arthritis: A cohort study

Al Zo’ubi,

Al Tarawneh,

Al Zaydi

et al. 2023

Int J of Rheum Dis

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Aim To determine the frequency of risk factors for cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) in Jordan. Method During this study, 158 patients with RA were enlisted from the outpatient rheumatology clinic at King Hussein Hospital of the Jordanian Medical Services, from 1 June 2021, to 31 December 2021. Demographic data and disease duration were recorded. After 14 h of fasting, venous blood samples were drawn to determine the levels of cholesterol, triglyceride, high‐density lipoprotein, and low‐density lipoprotein. History of smoking, diabetes mellitus, and hypertension was recorded. Body mass index and Framingham's 10‐year risk score (FRS) were calculated for each patient. Disease duration was noted. Results The mean age of the male population was 49.29 years and that of the female population was 46.06 years. Most of the study population were female (78.5%) and 27.2% of the study population had one modifiable risk factor. The most frequent risk factors observed in the study were obesity (38%) and dyslipidemia (38%). Diabetes mellitus was the least frequent risk factor, with a frequency of 14.6%. The FRS differed significantly between the sexes, with the risk score of men being 9.80, whereas that of women was 5.34 (p < .00). Regression analysis revealed that age increased the odds ratio of diabetes mellitus, hypertension, obesity, and a high‐to‐moderate FRS by 0.7%, 10.9%, 0.33%, and 10.3%, respectively. Conclusion Rheumatoid arthritis patients have increased chances of developing cardiovascular risk factors leading to cardiovascular events.

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“…The amount of pro-inflammatory peptide is also lowered in association with decreasing adiposity. Also, a rise in the concentration of anti-inflammatory molecules and, by extension, obesity is now thought to be proinflammatory states (12) . The pathogenesis of rheumatic diseases is thought to include adipokines, and recent research has shed light on their critical function as mediators of inflammation and the immune response (13) .…”

Section: Figure 1 Differences Between Different Groups Of Study In Rh...mentioning

confidence: 99%

The Correlation Study between Rheumatoid Arthritis and Obesity in Babylon Province

Mahdi¹,

Hussein²,

Dabbi³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: The prevalence of obesity has risen dramatically in recent years. History of obesity is a significant risk factor for the development of rheumatoid arthritis (RA).Objective: This study aimed to survy about obesity as a major threat for public health and attachment with other disease such as RA, and because several research refer to association to each other in differnet patients around the world. Subjects and Methods: It included 64 serum samples, classified as 16 from obese patients, 16 from rheumatoid patients, 16 from patients with both rheumatoid arthritis and obesity, and 16 from healthy individuals. All of these were recruited between October 2021 and August 2022, from different government hospital laboratory and private labs in Babylon City. Results:The results revealed significant differences (P>0.05) between control group and group of patients who had rheumatoid and obesity regarding the level of rheumatoid factor (RF), also showed positive correlation between body mass BMI and rheumatoid factor in the group of patients who had rheumatoid and obesity, but it revealed negative correlation between body mass index and rheumatoid factor in the group of patients who had obesity. Conclusion: Rehumatoid factor (RF) doesn't make important role in the obesity, and there is no association between rehumatoid arthritis and body mass index.

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Prevalence of obesity in rheumatoid arthritis and its association with disease activity and latex positivity in a sample of patients in Erbil

Cited by 7 publications

References 41 publications

Impact of obesity on rheumatoid arthritis: Relation with disease activity, joint damage, functional impairment and response to therapy

Impact of obesity on rheumatoid arthritis: Relation with disease activity, joint damage, functional impairment and response to therapy

Cardiovascular risk factors among Jordanian patients with rheumatoid arthritis: A cohort study

The Correlation Study between Rheumatoid Arthritis and Obesity in Babylon Province

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