Prevalence of obstructive sleep apnoea in acute coronary syndrome patients: systematic review and meta-analysis

Grande, Michael Le; Beauchamp, Alison; Driscoll, Andrea; Jackson, Alun C

doi:10.1186/s12872-020-01430-3

Cited by 26 publications

(17 citation statements)

References 53 publications

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“…In the literature, there are many arguments in support of the association between obstructive sleep apnoea syndrome (OSAS) and cardiovascular disease (CVD). Indeed, the prevalence of OSAS may reach 70.0% in individuals with CVD, and the incidence of CVD is high in apnoeic individuals [ 1 , 2 ]. In addition, OSAS is associated with a negative impact on cardiovascular prognosis, both in the general population and in individuals with CVD [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Risk of Cardiovascular Disease in Apnoeic Individuals: Role of Comorbid Insomnia Disorder

Hein

Wacquier

Lanquart

et al. 2022

Life

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Given the limited data available, the aim of this study was to examine the 10-year cardiovascular disease (CVD) risk associated with comorbid insomnia disorder and its specific subtypes in apnoeic individuals. Data from 1104 apnoeic individuals recruited from the database of the Erasme Hospital Sleep Laboratory were analysed. Only apnoeic individuals with a Framingham Risk Score ≥10% were included in the group at moderate-to-high 10-year CVD risk. Logistic regression analyses were conducted to examine the risk of 10-year CVD risk associated with comorbid insomnia disorder and its specific subtypes in apnoeic individuals. Moderate-to-high 10-year CVD risk was present in 59.6% of the apnoeic individuals in our sample. After adjustment for the main confounding factors, multivariate logistic regression analyses revealed that comorbid insomnia disorder and, more particularly, its subtype with short sleep duration were significantly associated with moderate-to-high 10-year CVD risk in apnoeic individuals. In this study, we demonstrate that comorbid insomnia disorder and, more specifically, its subtype with short sleep duration appear to have a negative cumulative effect on 10-year CVD risk in apnoeic individuals, which justifies more systematic research and adequate therapeutic management of this disorder to allow for better cardiovascular disease prevention in this particular subpopulation.

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Section: Introductionmentioning

confidence: 99%

Risk of Cardiovascular Disease in Apnoeic Individuals: Role of Comorbid Insomnia Disorder

Hein

Wacquier

Lanquart

et al. 2022

Life

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“…A meta-analysis by Le Grande et al reported that at any time after hospital admission for ACS, the pooled prevalence was 22% for severe OSA and 70% for mild OSA. 18…”

Section: Resultsmentioning

confidence: 99%

Prevalence of obstructive sleep apnoea among patients admitted with acute coronary syndrome in a hill state of northern India

Mahajan

Verma

Sharma

et al. 2022

NMJI

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Background Obstructive sleep apnoea (OSA) is one of the emerging non-traditional cardiovascular risk factors. Studying OSA may contribute towards a better understanding of current concepts of atherogenesis and in guiding therapy. Methods We conducted this cross-sectional study among 66 patients with acute coronary syndrome (ACS) in a tertiary care hospital from 1 January 2019 to 30 June 2020. We included patients of ST elevation myocardial infarction (STEMI)/ non-STEMI (on achieving Killip class I/II) and unstable angina and performed in-hospital overnight polysomnography (PSG) within 8 weeks of index event. Apnoea–hypoapnoea index (AHI) value 5–<15 was defined as mild OSA, AHI 15–<30 as moderate OSA and AHI >30 as severe OSA. We analysed data using Epi Info version 7.2.4 for Windows. Results The 66 patients had a mean (SD) age of 57.7 (11.1) years and 54 (81.8%) were men. Forty-three (65.1%) patients had STEMI, 19 (28.7%) had non-STEMI and 4 (6%) had unstable angina. On PSG, the prevalence of OSA (AHI>5) was 78.8% (95% CI 67.0–87.9). Of these, AHI >15 was significantly associated with diabetes, hypertension and different measures of obesity (p<0.05). Conclusions This study, conducted in a hill state of northern India, showed a high prevalence of OSA in patients with ACS. Obesity, diabetes mellitus and hypertension were significantly associated with severity of OSA (AHI>15).

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“…Obstructive sleep apnea (OSA) is a serious health hazard that requires long-term, multidisciplinary therapy and has a prevalence of 9% to 38% in the general population (1,2). Previous studies have shown that OSA is a significant independent factor for hypertension, diabetes, coronary heart disease and other diseases (3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Characteristics of Erectile Dysfunction in Obstructive Sleep Apnea Patients

et al. 2022

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BackgroundObstructive sleep apnea (OSA) is a common and severe social problem. Erectile dysfunction (ED) is an important health concern. The prevalence of OSA with ED is increasing, which significantly affects the quality of life and work efficiency of patients. However, the mechanism underlying the comorbidity of these two diseases remains unclear.Objectives(1) Investigate the prevalence of OSA with ED; (2) analyze the correlation between OSA and ED; and (3) explore the treatment response to and possible mechanism of uvulapalatopharyngoplasty (UPPP) in patients with OSA and ED. This study aims to provide a theoretical basis for the clinical diagnosis and comprehensive treatment of OSA with ED and improve prevention and treatment strategies.Materials and MethodsIn total, 135 subjects were enrolled in the study. Clinical data, polysomnography, the ESS score, Beck anxiety score, Beck depression score, IIEF-5 score and ASEX score were recorded before UPPP and 6 months after UPPP. Sex hormones were measured for all subjects using a Roche electrochemiluminescence analyzer.ResultThe prevalence of OSA with ED was 64.52%, and the prevalence of severe OSA with ED was 73.02%. The prevalence of OSA with ED increased with age, BMI and apnea-hypopnea index (AHI) value. Among polysomnography indicators, minimum oxygen saturation and average oxygen saturation may predict the occurrence of OSA with ED. Improving the patient’s anxiety and depression is very important for treating OSA with ED. Sex hormone levels were not significantly correlated with the occurrence of OSA with ED.ConclusionED is a common symptom of OSA patients. This study showed that sex hormone levels in OSA patients with ED were not significantly correlated with the condition, but further investigation of this relationship is worthwhile. It is recommended that the free and combined types of sex hormones be further distinguished during testing because the free type is the active form. UPPP surgical treatment is effective for OSA with ED, and its possible mechanism is protection of the peripheral nerves of the sex organs by improving nighttime hypoxia and arousal.

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Prevalence of obstructive sleep apnoea in acute coronary syndrome patients: systematic review and meta-analysis

Cited by 26 publications

References 53 publications

Risk of Cardiovascular Disease in Apnoeic Individuals: Role of Comorbid Insomnia Disorder

Risk of Cardiovascular Disease in Apnoeic Individuals: Role of Comorbid Insomnia Disorder

Prevalence of obstructive sleep apnoea among patients admitted with acute coronary syndrome in a hill state of northern India

Prevalence and Characteristics of Erectile Dysfunction in Obstructive Sleep Apnea Patients

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