Prevalence of Occult Celiac Disease in Patients with Iron-Deficiency Anemia: A Prospective Study

Abstract

The prevalence of occult celiac disease in this prospective study of patients presenting with iron-deficiency anemia was 2.8%. A significant number of other gastrointestinal lesions amenable to therapy were also found on upper and lower endoscopy in these patients. Given the treatable nature of celiac disease, it should be screened for in patients with unexplained iron-deficiency anemia with or without hemoccult-positive stools.

The prevalence of celiac disease in children with iron-deficiency anemia

“…The loss of iron in the sloughing intestinal enterocytes, malabsorption of dietary iron, and rarely gastrointestinal bleeding can contribute to the pathogenesis of IDA in CD (18). We found that the prevalence of CD in children with IDA was 21,3% in our study.…”

Gluten sensitive enteropathy in patients with iron deficiency anemia of unknown origin

“…One may speculate that some patients who were excluded before step 5, may have had GSE as well as another cause of IDA. The prevalence of GSE in IDA has been reported in previous studies [21][22][23] . In fact, the aim of our study was to evaluate GSE in a large population of patients with IDA of obscure origin.…”

“…Various rates of prevalence of GSE in IDA patients have been reported among different studies [21][22][23][24] . This discrepancy may be explained by patient selection criteria in the different studies.…”

The Prevalence of Celiac Disease in Patients With Iron-Deficiency Anemia in Center and South Area of Iran

“…IDA may be found in CD patients even in the lack of diarrhea or steatorrhea. The loss of iron in the bowel enterocytes, malabsorption of daily iron, and also rarely gastrointestinal bleeding may lead to the pathogenesis of IDA in CD (30) . Due to the development in diagnostic methods for determining CD, asymptomatic cases are actually the most common form of the disease, and are seven times more usual compared to clinically discovered patients (27) .…”