Prevalence of occult hepatitis B virus infection among hepatopathy patients and healthy people in China

Fang, Yong; Shang, Qing; Liu, Jianyu; Li, Di; Xu, Weizhen; Teng, Xu; Zhao, Hongwei; Fu, Lijuan; Zhang, Fengmin; Gu, Huiying

doi:10.1016/j.jinf.2009.02.013

Cited by 98 publications

(94 citation statements)

References 18 publications

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“…In northeast China, the prevalence rates of OBIs in IgG antiHBc-positive subjects were 100% (45/45), 86.7% (85/98), and 33.3% (14/42) in patients with cryptogenic chronic liver disease, HBsAg-negative patients with hepatocellular carcinoma, and HBsAg-negative healthy people, respectively. In these cases, the viral load was low (Ͻ10 4 viral copies/ml) (9). In Taiwan, a study that used HBV NAT yielded 12 cases among 10,727 seronegative donations (0.11%) (18).…”

Section: Discussionmentioning

confidence: 99%

Molecular Characteristics of Occult Hepatitis B Virus from Blood Donors in Southeast China

Yuan

Chen

et al. 2010

J Clin Microbiol

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Section: Discussionmentioning

confidence: 99%

Molecular Characteristics of Occult Hepatitis B Virus from Blood Donors in Southeast China

Yuan

Chen

et al. 2010

J Clin Microbiol

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“…The prevalence of serum/ plasma HBV DNA-reactive and HBsAg-and anti-HBc-negative infection was reported between 0.07% and 7.6% of tested subjects from different areas of endemicity (2,(17)(18)(19)(20).…”

mentioning

confidence: 99%

“…ultiple exposures to small amounts of hepatitis B virus (HBV) are of frequent occurrence in both occupational and nonoccupational settings (1)(2)(3)(4)(5)(6). Routine vaccination against HBV prevents infection potentially caused by such exposure.…”

mentioning

confidence: 99%

Repeated Exposure to Trace Amounts of Woodchuck Hepadnavirus Induces Molecularly Evident Infection and Virus-Specific T Cell Response in the Absence of Serological Infection Markers and Hepatitis

Gujar

Mulrooney‐Cousins

Michalak

2013

J Virol

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Exposure to multiple small doses of hepatitis B virus (HBV) is a frequent occurrence in high-risk groups, including close relatives of infected individuals, primary care givers, and intravenous drug users. It remains uncertain whether such repeated contact may culminate in a symptomatic infection coinciding with hepatitis in individuals not immunoprotected. In this study, we evaluated consequences of multiple exposures to small, liver-nonpathogenic amounts of infectious hepadnavirus in the woodchuck model of hepatitis B. Virus-naïve animals were intravenously injected with 6 weekly doses of 110 DNase digestion-protected virions of woodchuck hepatitis virus (WHV), injected again with 6 weekly 110-virion doses after 7.5 months, and then challenged or not with a liver-pathogenic dose of 1.1 ؋ 10 6 virions of the same inoculum. The data revealed that two rounds of such repeated exposure did not result in serologically evident infection or hepatitis. However, a low-level WHV DNA-positive infection accompanied by a WHV-specific T cell response in the absence of antiviral antibody reactivity was established. The kinetics of the virus-specific and mitogen-induced (generalized) T cell responses and the inability to induce immunoprotection against challenge with a large, liver-pathogenic virus dose were closely comparable to those previously reported for occult infection initiated by a single liver-nonpathogenic dose of WHV. Thus, repeated exposures to small quantities of hepadnavirus induce molecularly evident but serologically silent infection that does not culminate in hepatitis or generate immune protection. The findings imply that the HBV-specific T cell response encountered in the absence of serological markers of infection likely reflects ongoing occult infection. Multiple exposures to small amounts of hepatitis B virus (HBV) are of frequent occurrence in both occupational and nonoccupational settings (1-6). Routine vaccination against HBV prevents infection potentially caused by such exposure. However, consequences of repeated contacts with small quantities of HBV of individuals not immunoprotected against the virus are not recognized and it is unknown whether such exposure can culminate in a serologically detectable infection and hepatitis.The data acquired from the woodchuck model of hepatitis B showed that exposure to a singular low dose (i.e., Ͻ1,000 virions) of woodchuck hepatitis virus (WHV), which is a close relative of HBV (7-9), establishes serologically undetectable infection in which the virus genome and its replication are detectable when nucleic acid amplification assays of enhanced sensitivity are applied (10-13). This molecularly evident but immunovirologically silent infection was designated primary occult infection (POI) (12,14). POI was originally uncovered in offspring born to woodchuck dams convalescent from experimental acute hepatitis (AH) (15). In these animals, WHV DNA was identified in serum and in the immune system but not in the liver and virus replication progressed at a very low level ...

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“…The highest prevalence was seen among donors in age group <30 years. Less frequently infected with hepatitis had positive in patient less than 70 years (Reekie et al, 2014) The prevalence of Hepatitis surface antigen is slightly higher in males than females In female group (Emad et al, 2012) Risk factor for HBV infection may vary considerably depending on epidemiological data, the geographic region and the social, cultural characteristics of different population (Fang et al, 2009) The risk factors were included i.e. gender and age in which it has been found that Hepatitis infection in men (51%) is higher than that in women (48.9%) within the age group of 20-60 years.…”

Section: Clinical Sample Distribution According To Agementioning

confidence: 99%

Untitled

2018

Int. J. Curr. Res. Biosci. Plant Biol.

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This study was conducted to detect the prevalence of Hepatitis C virus and Hepatitis B virus of infected Patients. The study was carried out in the period from January (2016) to December (2016). The study included 420 hepatitis C and B virus suspected patients from Al-Hakeem Hospital, AL-Sader Hospital and Middle Euphrates Hospital in AlNajaf Province with gender and age ranged from (<10-70) years old from both sexes. Patients group was found to be 120 patients infected with Hepatitis represented47 Hepatitis C and 73 Hepatitis B the results of the study showed that the highest rate of infection was in HBV. Our study found the male infected with hepatitis(70.7%) and female infected with hepatitis (29.2%) so the male more infection for hepatitis then female, also we found the patients children under <10 years less infected with hepatitis and more age infected with hepatitis 20-29 and followed by age30-39 and 40-49.

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Prevalence of occult hepatitis B virus infection among hepatopathy patients and healthy people in China

Cited by 98 publications

References 18 publications

Molecular Characteristics of Occult Hepatitis B Virus from Blood Donors in Southeast China

Molecular Characteristics of Occult Hepatitis B Virus from Blood Donors in Southeast China

Repeated Exposure to Trace Amounts of Woodchuck Hepadnavirus Induces Molecularly Evident Infection and Virus-Specific T Cell Response in the Absence of Serological Infection Markers and Hepatitis

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