Prevalence of Occult Hepatitis B and Hepatitis C Virus Infections in Turkish Hemodialysis Patients

Yakaryılmaz, Fahri; Gürbüz, Oğuz Alp; Güliter, Sefa; Mert, Ali; Songür, Yıldıran; Karakan, Tarkan; Keleş, Hatice

doi:10.1080/08860220600925602

Cited by 92 publications

(69 citation statements)

References 40 publications

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“…In another study conducted in Turkey, 13% of recruited hemodialysis patients were HBsAg positive, 20% were HCV positive, and 4% showed HBV and HCV coinfections (4). The prevalence of HBV and HCV has been studied previously in Iraq in different groups, such as blood donors, healthcare workers, and thalassaemia patients (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of HIV, HCV, and HBV Among Hemodialysis Patients Attending Duhok Hemodialysis Center

2017

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Background: Blood-borne viral infection is a public health problem, especially in high-risk patients, including those with renal failure. Objectives: The aim of this study was to investigate the prevalence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections in patients undergoing hemodialysis. Methods: In this study, 94 patients were recruited and examined for HBV surface antigen (HBsAg), HCV antibodies (HCVAb), and HIV using ELISA assay. HCV positivity was confirmed via real-time polymerase chain reaction (RT-PCR). The patients were followed-up by testing their blood samples for HBsAg, HCVAb, and HIV on a monthly basis. Results: At the beginning of the study, 3 out of 94 (3.2%) patients were HBsAg positive. In addition, 4 out of 94 (4.3%) patients were HCVAb positive; HCV-positive patients were confirmed via RT-PCR. In addition, three new samples (2 males and 1 female) became HCVAb positive during the follow up. New cases of infection might be associated with exposure to inadequately sterilized dialysis. All the recruited patients were negative for HIV throughout the study. Conclusions:The prevalence of HBsAg and HCV positivity in subjects undergoing hemodialysis was comparable to most neighboring countries. Strict infection control measures should be taken to prevent infection transmission.

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Section: Introductionmentioning

confidence: 99%

The Prevalence of HIV, HCV, and HBV Among Hemodialysis Patients Attending Duhok Hemodialysis Center

2017

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“…In general, North Africa and the Middle East were cited as high prevalence areas, both in the general population and in HD patients, by the WHO in 1999 [9] . Previous studies from the region have reported a prevalence of anti-HCV antibodies in HD patients of 50% in Saudi Arabia in 2000 [10] , 19.1% in Tunisia in 1994 [11] , 20.2% in Turkey in 2006 [12] and 34.6% in Jordan in 2007 [13] . Concerning the prevalence of HBV, Abourached et al [5] reported on 2007 a prevalence of 2.62% (0%-6.5%) of HBsAg in 17 HD centers in Lebanon, our study showed a decrease of the prevalence to 1.6%, ranging from 1.4% in Nabatieh and Bekaa, to 2.4% in the North.…”

Section: Resultsmentioning

confidence: 99%

“…Incidence (per patient-year) = [(Total number of acquired infection)/(Total patient|month)]/ 12 We did the statistical analysis separately for HBV and HCV.…”

Section: Incidence Analysismentioning

confidence: 99%

Incidence and prevalence of hepatitis B and hepatitis C viruses in hemodialysis patients in Lebanon

Rached

Khoury

Imad

et al. 2016

WJN

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AIM:To determine the incidence and the prevalence of hepatitis B and C viral infections in patients on hemodialysis (HD) across Lebanon. METHODS:We reviewed the data registry at the Lebanese Ministry of Public Health where records of monthly hepatitis B surface antigen (HBsAg) and hepatitis C virus (HCV) serology are reported from 60 affiliated HD centers across Lebanon. All patients who were on HD or who started HD between October 2010 and July 2012 were included in the study. Patients from seven HD centers were excluded due to inadequate and incomplete results reporting. During the selected Retrospective Study ORIGINAL ARTICLEperiod, HBsAg and HCV serology were available for 3769 patients from 53 HD centers distributed at all Lebanese governorates. The prevalence was calculated by dividing the number of patients with positive HBsAg or HCV serology to the total number of patients. The Incidence was calculated by dividing the number of newly acquired infection to number of patients-years (p-y). Incidence rates at different governorates were compared to each other using two tailed Z test and a P value of < 0.05 was considered significant. RESULTS:Sixty out of 3769 HD patients were found to have positive HBS Ag and 177 out of 3769 were positive for HCV Antibodies. The prevalence of hepatitis B virus (HBV) and HCV in HD patients across Lebanon was 1.6%, and 4.7%, respectively. The comparison of prevalence according to geographic distribution could not be done accurately due to the frequent shift of patients between dialysis centers at different governorates. The incidence rate was 0.27 per 100 p-y for HBV and 0.37 per 100 p-y for HCV. There was no significant difference concerning the incidence of HBV between HD centers at different governorates (all P values > 0.1), but this difference was highly significant concerning the incidence rates of HCV which occurred predominantly in the southern centers (1.47 per 100 p-y) with a P value of 0.00068 and 0.00374 when compared to Mount Lebanon (0.21 per 100 p-y) and the Northern centers (0.19 per 100 p-y), respectively. CONCLUSION:The incidence rate of HBV and HCV is very low in the Lebanese HD centers and their prevalence is decreasing over the last two decades.

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“…12 This criteria has been modified by some workers to define occult HCV infection as anti-HCV negative and HCV-RNA positive by PCR while evaluating the prevalence of HCV infection in patients on dialysis. [9][10][11] We used the same criteria and performed quantitative HCV-RNA assay by real time PCR to assess the prevalence of occult HCV infection in RT patients on our follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have also defined occult HCV infection as anti-HCV negative and HCV-RNA positive by polymerase chain reaction (PCR) while evaluating the prevalence of HCV infection in patients on dialysis. [9][10][11] But there is a lack of data on the prevalence of occult HCV infection in RT patients. We studied the prevalence of occult HCV infection in RT recipients on our follow-up and analysed the factors that influence this prevalence.…”

Section: Introductionmentioning

confidence: 99%

High prevalence of hepatitis C virus-ribonucleic acid positivity in anti-hepatitis C virus negative renal transplant patients

Hooda

Varma

Chopra

et al. 2012

Medical Journal Armed Forces India

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Prevalence of Occult Hepatitis B and Hepatitis C Virus Infections in Turkish Hemodialysis Patients

Abstract: Both occult and non-occult forms of HCV infection are more prevalent than HBV infection in hemodialysis patients. Especially the patients with isolated anti-HBc positivity should be tested for probable occult hepatitis B infection.

Cited by 92 publications

References 40 publications

The Prevalence of HIV, HCV, and HBV Among Hemodialysis Patients Attending Duhok Hemodialysis Center

The Prevalence of HIV, HCV, and HBV Among Hemodialysis Patients Attending Duhok Hemodialysis Center

Incidence and prevalence of hepatitis B and hepatitis C viruses in hemodialysis patients in Lebanon

High prevalence of hepatitis C virus-ribonucleic acid positivity in anti-hepatitis C virus negative renal transplant patients

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