Prevalence of Ocular Surface Disease in Glaucoma Patients Using Anti-Glaucoma Medicatons.

Abstract

To evaluate the prevalence of ocular surface disorder (OSD) in patients using anti-glaucoma medications METHODS; 150 eyes of 75 glaucoma patients on topical anti-glaucoma medication with preservatives were studied. Patients with history of use of topical corticosteroids, cyclosporine, anti-inflammatory drugs or other topical medications within last 3 months were excluded. Patients completed Ocular Surface Disease Index questionnaire, underwent evaluation by Schirmer test, tear breakup time, corneal and conjunctival lissamine green staining. RESULTS; Mean age of patients was 56.5 (range 23-80) years. 50 (67%) patients were males and 25 (33%) patients were females.56% patients had primary open angle glaucoma. 41% patients had primary angle glaucoma. 3% patients had ocular hypertension. 44 (59%) patients were on single medication. 25 (33%) patients were on two medications. 6 (8%) patients were on three medications. Mean duration of using medication was 3.8 yrs (range; 5 months-16 yrs). Duration less than 1yrs-10(13%) patients. 1 to 5 yrs-36(48%) patients. 5 to 1yrs-19(26%) patients. More than 10yrs-10(13%) patients. 32% patients reported symptoms in at least one eye. Severe symptoms were reported by none. Tear breakup time was abnormal in 54.5% patients, severe abnormality in 20.5% patients. Schirmer testing showed 50.5% patients with decreased tear production in at least one eye, severe tear deficiency in 21.5% patients. Lissamine green staining of conjunctival and cornea showed positive results in 47% patients. None had severe staining. As