Prevalence of oncogenic driver mutations in Hispanics/Latin patients with lung cancer. A systematic review and meta-analysis

Parra-Medina, Rafael; Castañeda-González, Juan Pablo; Montoya, Luisa; Paula Gómez-Gómez, María; Clavijo Cabezas, Daniel; Plazas Vargas, Merideidy

doi:10.1016/j.lungcan.2023.107378

Cited by 4 publications

(2 citation statements)

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“…The prevalence of driver mutations in lung cancer patients exhibits variation influenced by factors such as ethnicity, smoking status, and gender [ 6 ]. A recent systematic review and metanalysis [ 7 ] aimed to ascertain the prevalence of actionable mutations specifically in the Hispanic/Latino population diagnosed with non-small cell lung cancer (NSCLC). This comprehensive analysis involved the extraction and examination of clinical data from 55 articles.…”

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confidence: 99%

“…The prevalence of EGFR varies significantly across different populations: it is estimated at 38.8% in Asian populations, 17.4% in White populations, and 17.2% in Black populations [ 8 ]. The systematic review and metanalysis [ 7 ] also found that the mean of KRAS mutation was a 14% prevalence. KRASG12C was the most frequent mutation with a 7% prevalence in an entire population.…”

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confidence: 99%

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Exploring oncogenic driver molecular alterations in hispanic/latin american cancer patients: A call for enhanced molecular understanding

Parra-Medina

2024

Oncoscience

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confidence: 99%

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confidence: 99%

Exploring oncogenic driver molecular alterations in hispanic/latin american cancer patients: A call for enhanced molecular understanding

Parra-Medina

2024

Oncoscience

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Detection of NTRK fusions by RNA-based nCounter is a feasible diagnostic methodology in a real-world scenario for non-small cell lung cancer assessment

de Oliveira Cavagna,

de Andrade,

Tadin Reis

et al. 2023

Sci Rep

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NTRK1, 2, and 3 fusions are important therapeutic targets for NSCLC patients, but their prevalence in South American admixed populations needs to be better explored. NTRK fusion detection in small biopsies is a challenge, and distinct methodologies are used, such as RNA-based next-generation sequencing (NGS), immunohistochemistry, and RNA-based nCounter. This study aimed to evaluate the frequency and concordance of positive samples for NTRK fusions using a custom nCounter assay in a real-world scenario of a single institution in Brazil. Out of 147 NSCLC patients, 12 (8.2%) cases depicted pan-NTRK positivity by IHC. Due to the absence of biological material, RNA-based NGS and/or nCounter could be performed in six of the 12 IHC-positive cases (50%). We found one case exhibiting an NTRK1 fusion and another an NTRK3 gene fusion by both RNA-based NGS and nCounter techniques. Both NTRK fusions were detected in patients diagnosed with lung adenocarcinoma, with no history of tobacco consumption. Moreover, no concomitant EGFR, KRAS, and ALK gene alterations were detected in NTRK-positive patients. The concordance rate between IHC and RNA-based NGS was 33.4%, and between immunohistochemistry and nCounter was 40%. Our findings indicate that NTRK fusions in Brazilian NSCLC patients are relatively rare (1.3%), and RNA-based nCounter methodology is a suitable approach for NRTK fusion identification in small biopsies.

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Beyond tobacco: genomic disparities in lung cancer between smokers and never-smokers

Garrido,

Bernal,

González

et al. 2024

BMC Cancer

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Prevalence of oncogenic driver mutations in Hispanics/Latin patients with lung cancer. A systematic review and meta-analysis

Cited by 4 publications

References 93 publications

Exploring oncogenic driver molecular alterations in hispanic/latin american cancer patients: A call for enhanced molecular understanding

Exploring oncogenic driver molecular alterations in hispanic/latin american cancer patients: A call for enhanced molecular understanding

Detection of NTRK fusions by RNA-based nCounter is a feasible diagnostic methodology in a real-world scenario for non-small cell lung cancer assessment

Beyond tobacco: genomic disparities in lung cancer between smokers and never-smokers

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