Prevalence of oncogenic human papillomavirus in pregnant adolescents, association with colpocytological changes, risk factors and obstetric outcomes

Souza, Henrique Diório de; Waissman, Adriana Lippi; Diório, Giselle Rodrigues Mota; Peres, Stela Verzinhasse; Francisco, Rossana Pulcineli Vieira; Galletta, Marco Aurélio Knippel

doi:10.1016/j.clinsp.2022.100127

Cited by 3 publications

(10 citation statements)

References 51 publications

(72 reference statements)

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“…Souza et al conducted a study in Brazil including 303 adolescent women during pregnancy and found that 50.5% were detected with HR-HPV [ 1 ], but several other studies suggest that this rate varies between 5.8% and 51.7% [ 9 , 10 , 19 ]. This study also showed that low-grade squamous intraepithelial lesions (LSIL) and atypical squamous cells of undetermined significance (ASCUS) were associated with HR-HPV.…”

Section: Reviewmentioning

confidence: 99%

“…This study also showed that low-grade squamous intraepithelial lesions (LSIL) and atypical squamous cells of undetermined significance (ASCUS) were associated with HR-HPV. Nevertheless, Souza et al suggest that both HPV infection and cervical lesions tend to regress [ 1 ]. In addition, Aydin et al in their study support that HR-HPV prevalence in pregnant women (14.6%) compared to non-pregnant women (9.8%) living in Turkey is statistically significantly different.…”

Section: Reviewmentioning

confidence: 99%

“…There are limited available data in the literature regarding HPV-DNA test comparisons between pregnant and non-pregnant populations, providing quite inadequate information in order to draw safe conclusions. Although it is known that pregnancy does not alter the disease progress of HPV infection to cervical cancer [ 1 , 5 , 8 - 10 ], most previously reported studies support that HPV-DNA detection rates are higher during pregnancy and HR-HPV genotypes are most common in pregnant women [ 14 , 15 ], as well. There is also controversial information referring to the correlation between gestational age and HPV-DNA detection rates from published literature [ 13 , 15 ].…”

Section: Reviewmentioning

confidence: 99%

“…Human papillomavirus (HPV), a double-stranded DNA virus, is known to incorporate into epithelial cells and, under specific circumstances, trigger proliferation [ 1 ]. HPV infects various human tissue epithelial cells such as oral, genital, or skin mucosa, and its persistence could potentially lead to benign, precancer lesions and progression to cancer as well [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…An HPV infection underlies virtually all causes of cervical cancer, both in pregnant and non-pregnant women [ 1 , 4 , 5 ]; thus, vaccination strategies have been developed as a prevention tool. The prevalence of cervical cancer in pregnant women ranges between 0.80 and 1.50 cases out of 10,000 births and one to three of the 100 women diagnosed with cervical cancer are pregnant or in the postpartum period at that time.…”

Section: Introductionmentioning

confidence: 99%

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The HPV-DNA Test in Pregnancy: A Review of the Literature

Ζαγοριανάκου¹,

Mitrogiannis²,

Konis³

et al. 2023

Cureus

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Human papillomavirus (HPV) is a virtually necessary cause of cervical cancer, and HPV genotypes are categorized either as high-risk or low-risk based on their potential to cause malignancy of the cervix. HPV-DNA detection is used widely for screening women at risk. However, its clinical significance is not proven sufficiently in pregnancy. The aim of this review was to summarize published data referring to the integration of the HPV-DNA test in cervical cancer screening during pregnancy. PubMed and Scopus were searched for articles investigating the HPV-DNA test during pregnancy as a primary association; greater interest was placed on studies published after 2000. Retrieved articles reported similarities or discrepancies in the HPV-DNA test in pregnant women compared to those who are not pregnant, its accuracy, and its integration in cervical cancer screening. The HPV-DNA test may constitute a helpful tool utilized for monitoring, risk stratification, and triage of cases that require colposcopy. If combined with the HPV-mRNA test, this might improve its specificity. However, when compared to HPV-DNA detection rates in non-pregnant women, the results were ambiguous, without giving the opportunity to draw safe conclusions. Both those findings and the high cost hold it back from wide use. Hence, the Papanicolaou smear (Pap smear) is still the first-line diagnostic tool and colposcopy-guided cervical biopsy is the “gold standard” method for the management of cervical intraepithelial neoplasia (CIN) treatment during pregnancy.

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The HPV-DNA Test in Pregnancy: A Review of the Literature

Ζαγοριανάκου¹,

Mitrogiannis²,

Konis³

et al. 2023

Cureus

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Human Papillomavirus Infection among pregnant women treated in primary health care: a cross-sectional study

Santos Nunes,

Nunes de Azevedo,

Luz Torres Silva

et al. 2024

J. nurs. health.

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Objective: verify the prevalence of Human Papillomavirus in pregnant women and the concordance of detection between urine and cervical-vaginal samples. Methods: samples were collected from 110 women in the second trimester of pregnancy in the city of Coari, Amazonas. Detection of the virus was performed using Polymerase Chain Reaction using the PGMY09/11 primer set. Results: 24.6% of pregnant women were infected, with the virus present in 11.8% of urine samples and in 23.6% of cervical-vaginal samples. There was 86.4% agreement and a moderate agreement rate between biological samples (kappa = 0.543). A statistically significant association was found between Human Papillomavirus infection and the variables: age of pregnant women (p= 0.014), first pregnancy (p= 0.027) and nulliparity (p= 0.046). Conclusions: the cervical-vaginal sample proved to be more suitable for detecting the virus and the high prevalence found reinforces the need to closely monitor this infection during pregnancy.

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HPV Prevalence in pregnant women

Pinto e Grossi,

Acosta

2023

SCT Proceedings in Interdisciplinary Insights and Innovations

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Background: Human Papilloma virus (HPV) is very common virus in the global population. It is mainly transmitted through sexual contact and can also be transmitted from mother to child during childbirth. There are more than 100 different types of HPV, and most infected individuals do not present symptoms. However, some types of HPV can cause genital warts, while others can lead to change in cervical cells, increasing the risk of cervical cancer development. The best way to prevent HPV infection is through vaccination, along with use of condoms during secual intercourse. It Is essential for women to undergo regular screenings such as Pap test and colposcopy, as they help in the early detection of any cellular changes in the cervix and receiving appropriate treatment if necessary.. Material and methods: This is a retrospective observational study conducted by analyzing the medical records of pregnant women who gave birth in the year 2017 at The Ana Goitia maternal and Child Specialized Hospital. Results: From this research work, we arrived at the result that 24,2%(n=78) of pregnant women underwent the papanicolaou test. Amog them, 71%(n=55) tested negative, 27%(n=21) were classified as PAP class 2 and 2%(n=2) positive for HPV. Conclusion: After analyzing de medical records of the mentioned hospital, it was evident that very few individuals had undergone the papanicolaou test. As consequence, a low number of pregnant women were found to have any abnormalities in the test o tested positive for HPV. This made in challenging to determine the prevalence of this disease In the study population

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Prevalence of oncogenic human papillomavirus in pregnant adolescents, association with colpocytological changes, risk factors and obstetric outcomes

Cited by 3 publications

References 51 publications

The HPV-DNA Test in Pregnancy: A Review of the Literature

The HPV-DNA Test in Pregnancy: A Review of the Literature

Human Papillomavirus Infection among pregnant women treated in primary health care: a cross-sectional study

HPV Prevalence in pregnant women

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