Prevalence of Onychomycosis in Diabetic Patients: A Case-Control Study Performed at University Hospital Policlinico in Catania

Trovato, Laura; Calvo, Maddalena; Pasquale, Rocco De; Scalia, Guido; Oliveri, Salvatore Massimo

doi:10.3390/jof8090922

Cited by 11 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sufficient data were available to compare the prevalence of NDM onychomycosis in clinically suspected patients who underwent single ( n = 81,515) or repeat sampling ( n = 32,171) 16,50–112 . Across both Global North and Global South regions, results from studies where single sampling is performed showed a higher degree of variability compared to studies that utilized the recommended repeat sampling approach (Figure 3).…”

Section: Resultsmentioning

confidence: 99%

Global prevalence of onychomycosis in general and special populations: An updated perspective

Gupta,

Wang,

Polla Ravi

et al. 2024

Mycoses

View full text Add to dashboard Cite

BackgroundOnychomycosis is a chronic nail disorder commonly seen by healthcare providers; toenail involvement in particular presents a treatment challenge.ObjectiveTo provide an updated estimate on the prevalence of toenail onychomycosis.MethodsWe conducted a literature search using PubMed, Embase and Web of Science. Studies reporting mycology‐confirmed diagnoses were included and stratified into (a) populations‐based studies, and studies that included (b) clinically un‐suspected and (c) clinically suspected patients.ResultsA total of 108 studies were included. Based on studies that examined clinically un‐suspected patients (i.e., with or without clinical features suggestive of onychomycosis), the pooled prevalence rate of toenail onychomycosis caused by dermatophytes was 4% (95% CI: 3–5) among the general population; special populations with a heightened risk include knee osteoarthritis patients (RR: 14.6 [95% CI: 13.0–16.5]), chronic venous disease patients (RR: 5.6 [95% CI: 3.7–8.1]), renal transplant patients (RR: 4.7 [95% CI: 3.3–6.5]), geriatric patients (RR: 4.7 [95% CI: 4.4–4.9]), HIV‐positive patients (RR: 3.7 [95% CI: 2.9–4.7]), lupus erythematosus patients (RR: 3.1 [95% CI: 1.2–6.3]), diabetic patients (RR: 2.8 [95% CI: 2.4–3.3]) and hemodialysis patients (RR: 2.8 [95% CI: 1.9–4.0]). The prevalence of onychomycosis in clinically suspected patients was significantly higher likely due to sampling bias. A high degree of variability was found in a limited number of population‐based studies indicating that certain pockets of the population may be more predisposed to onychomycosis. The diagnosis of non‐dermatophyte mould onychomycosis requires repeat sampling to rule out contaminants or commensal organisms; a significant difference was found between studies that performed single sampling versus repeat sampling. The advent of PCR diagnosis results in improved detection rates for dermatophytes compared to culture.ConclusionOnychomycosis is an underrecognized healthcare burden. Further population‐based studies using standardized PCR methods are warranted.

show abstract

Section: Resultsmentioning

confidence: 99%

Global prevalence of onychomycosis in general and special populations: An updated perspective

Gupta,

Wang,

Polla Ravi

et al. 2024

Mycoses

View full text Add to dashboard Cite

show abstract

“…Furthermore, in our study, patients with diabetes had increased risk of onychomycosis development similar to previous literature. For example, in a 2016 Italian retrospective study including 668 non-diabetic and 47 diabetic patients, 55.3% (N = 26) of diabetic patients and 25.2% (N = 169) of non-diabetic patients were diagnosed with onychomycosis (P < 0.0001) [ 39 ]. In a 2008–2009 Japanese cross-sectional observational study of 71 patients, an unadjusted multiple logistic regression model found that not washing feet every-day was associated with a significantly increased risk of onychomycosis among diabetic patients (OR: 3.45, 95% CI: 1.24–9.65; P = 0.018), though data was not significant in the age and sex adjusted model (OR: 2.37; 95% CI: 0.76–7.33; P = 0.136) [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of Onychomycosis Risk Factors Using the 2003-2014 National Inpatient Sample

Shah,

Desai,

Lipner

2024

Dermatology Practical &Amp; Conceptual

View full text Add to dashboard Cite

Introduction: Onychomycosis, a fungal nail infection, is associated with significant morbidity and negative impact on quality of life. Therefore, understanding associated risk factors may inform onychomycosis screening guidelines. Objectives: This retrospective study investigated common demographic and comorbidity risk factors among hospitalized patients using the National Inpatient Sample. Methods: The 2003-2014 National Inpatient Sample (NIS) database was used to identify onychomycosis cases and age and sex matched controls in a 1:2 ratio. Chi-square tests and T-tests for independent samples were utilized to compare categorical and continuous patient factors. Demographic and comorbidity variables significant (p<0.05) on univariate analysis were analyzed via a multivariate regression model with Bonferroni correction (p<0.0029). Results: 119,662 onychomycosis cases and 239,324 controls were identified. Compared to controls, onychomycosis patients frequently were White (69.0% vs. 68.0%; p<0.001), Black (17.9% vs. 5.8%; p<0.0001), and insured by Medicare or Medicaid (80.1% vs. 71.1%; p<0.0001). Patients had greater hospital stays (9.69 vs. 5.39 days; p<0.0001) and costs ($39,925 vs. $36,720; p<0.001) compared to controls. On multivariate analysis, onychomycosis was commonly associated with tinea pedis (OR: 111.993; p<0.0001), human immunodeficiency virus (OR: 4.372; p<0.001), venous insufficiency (OR: 6.916; p<0.0001), and psoriasis (OR: 3.668; p<0.001). Conclusion: Onychomycosis patients had longer hospital stays and greater costs compared to controls. Black patients were disproportionately represented among cases compared to controls. Onychomycosis was associated with tinea pedis, venous insufficiency, human immunodeficiency virus, psoriasis, obesity (BMI ≥ 30 kg/m2), peripheral vascular disease, and diabetes with chronic complications, suggesting that inpatients with onychomycosis should be screened for these conditions.

show abstract

“…Skin reactions caused by insulin therapy: lipohypertrophy (most common manifestation, at the site of insulin injection), lipoatrophy, erythema, local infections, subcutaneous nodules, allergies [ 24 ]. Lipohypertrophy is the most common local reaction after insulin injection, affecting approximately 27% of patients.…”

Section: Introductionmentioning

confidence: 99%

“…The drugs frequently incriminated belong to the sulphonylurea class (glibenclamide, tolbutamide, chlorpropamide), which, according to some authors, also induce psoriatic or lichenoid eruptions. The occurrence of pemphigus vulgaris has also been reported very rarely [ 4 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous Manifestations Associated with Diabetes Mellitus—A Retrospective Study

Vâță,

Stanciu,

Temelie-Olinici

et al. 2023

Diseases

View full text Add to dashboard Cite

Diabetes mellitus (DM) is one of the world’s most important health problems, affecting more than half a billion of the world’s population today, with an ever-increasing prevalence. Among the most common manifestations of diabetes are skin manifestations, with 30–70% of patients experiencing skin complications during the course of the disease. Conditions such as acanthosis nigricans, diabetic dermopathy, necrobiosis lipoidica, bacterial infections, fungal infections, skin xerosis, and metabolic prurigo are often associated with diabetes and often precede its diagnosis. We conducted a retrospective study on a group of 103 patients hospitalized between January 2018 and December 2022, in a clinic of a county hospital, using as criteria the diagnosis of diabetes mellitus complicated by cutaneous manifestations frequently associated with diabetes. The aim was to observe which are the most common manifestations and whether they correlate with data in the research literature. In the present study, manifestations such as diabetic foot (20% of patients), bacterial (35%) and fungal infections, and cutaneous xerosis (45%) were predominant. Often, the integumentary involvement may precede the diagnosis of the underlying disease. It is therefore very important to recognize, investigate and treat these manifestations as soon as possible.

show abstract

Prevalence of Onychomycosis in Diabetic Patients: A Case-Control Study Performed at University Hospital Policlinico in Catania

Cited by 11 publications

References 25 publications

Global prevalence of onychomycosis in general and special populations: An updated perspective

Global prevalence of onychomycosis in general and special populations: An updated perspective

Retrospective Analysis of Onychomycosis Risk Factors Using the 2003-2014 National Inpatient Sample

Cutaneous Manifestations Associated with Diabetes Mellitus—A Retrospective Study

Contact Info

Product

Resources

About