Prevalence of ophthalmic diseases in the population older than 50 years

Munz, I V; Direev, A. O.; Gusarevitch, O G; Щербакова, Л. В.; Маздорова, Е. В.; Malyutina, Sofia

doi:10.17116/oftalma2020136031106

Cited by 9 publications

(1 citation statement)

References 18 publications

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“…DR is a leading cause of vision loss and blindness in people with diabetes. Nearly forty percent of diabetes patients demonstrated different forms of DR [4], and diabetes is one of the top five reasons that the population older than 50 years has ophthalmic diseases [5]. The retinal pigment epithelium (RPE), located between the vascular choroids and the neurosensory retina, forms the protected outer blood-retinal barrier, which maintains the normal structural and function of retina.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Fucoxanthin on High Glucose- and 4-Hydroxynonenal (4-HNE)-Induced Injury in Human Retinal Pigment Epithelial Cells

et al. 2020

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The incidence of diabetes mellitus is increasing due to the eating and living habits of modern people. As the disease progresses, the long-term effects of diabetes can cause microvascular disease, causing dysfunction in different parts of the body, which, in turn, leads to different complications, such as diabetic neuropathy, diabetic nephropathy, and diabetic retinopathy (DR). DR is the main cause of vision loss and blindness in diabetic patients. Persistent hyperglycemia may cause damage to the retina, induce the accumulation of inflammatory factors, and destroy the blood–retinal barrier function. Fucoxanthin (Fx) is a marine carotenoid extracted from seaweed. It accounts for more than 10% of the total carotenoids in nature. Fx is mainly found in brown algae and has strong antioxidant properties, due to its unique biologically active structure. This carotenoid also has the effects of reducing lipid peroxidation, reducing DNA damage, and preventing cardiovascular diseases as well as anti-inflammatory and anti-tumor effects. However, there is no relevant research on the protective effect of Fx in DR. Therefore, in this study, we explore the protective effect of Fx on the retina. Human retinal epithelial cells (ARPE-19) are used to investigate the protective effect of Fx on high glucose stress- (glucose 75 mM) and high lipid peroxidation stress (4-hydroxynonenal, 4-HNE (30 μM))-induced DR. The cell viability test shows that Fx recovered the cell damage, and Western blotting shows that Fx reduced the inflammation response and maintained the integrity of the blood–retinal barrier by reducing its apoptosis and cell adhesion factor protein expression. Using an antioxidant enzyme assay kit, we find that the protective effect of Fx may be related to the strong antioxidant properties of Fx, which increases catalase and reduces oxidative stress to produce a protective effect on the retina.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Fucoxanthin on High Glucose- and 4-Hydroxynonenal (4-HNE)-Induced Injury in Human Retinal Pigment Epithelial Cells

et al. 2020

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Global and Regional Prevalence of Diabetic Retinopathy; A Comprehensive Systematic Review and Meta-analysis

Hashemi

Rezvan

Pakzad

et al. 2021

Seminars in Ophthalmology

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Modulation transfer function formula for different age ranges

Sánchez,

Puertas,

Issolio

2023

J. Opt. Soc. Am. A

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The modulation transfer function (MTF) is one of the most complete tools to study the optical performance of the eye. We present the average radial MTF profiles measured in 68 subjects grouped in six age ranges (from 20 to 80 years) and a general formula to estimate the radial profile of human MTF as a function of pupil size and age. The mean MTF for each age group was fitted to an analytical expression to compute two parameters related to aging. The proposed formula fitted reasonably well to experimental data available in previous works and predicted the average changes with aging of different optical quality parameters obtained from MTF.

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Prevalence of ophthalmic diseases in the population older than 50 years

Cited by 9 publications

References 18 publications

Protective Effects of Fucoxanthin on High Glucose- and 4-Hydroxynonenal (4-HNE)-Induced Injury in Human Retinal Pigment Epithelial Cells

Protective Effects of Fucoxanthin on High Glucose- and 4-Hydroxynonenal (4-HNE)-Induced Injury in Human Retinal Pigment Epithelial Cells

Global and Regional Prevalence of Diabetic Retinopathy; A Comprehensive Systematic Review and Meta-analysis

Modulation transfer function formula for different age ranges

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