Prevalence of optical coherence tomography detected vitreomacular interface disorders: The Maastricht Study

Abstract

PurposeTo calculate the prevalence of all vitreomacular interface (VMI) disorders and stratify according to age, sex and (pre)diabetes status.MethodsThe presence of VMI disorders was assessed in 2660 participants aged between 40 and 75 years from The Maastricht Study who had a gradable macular spectral‐domain optical coherence tomography (SD‐OCT) volume scan in at least one eye [mean 59.7 ± 8.2 years, 50.2% men, 1531 normal glucose metabolism (NGM), 401 prediabetes, 728 type 2 diabetes (DM2, oversampled)]. A stratified and multivariable logistic regression analysis was used.ResultsThe prevalence of the different VMI disorders for individuals with NGM, prediabetes and DM2 was, respectively, 5.7%, 6% and 6.7% for epiretinal membranes; 6%, 9.6% and 6.8% for vitreomacular traction; 1.1%, 0.7% and 0.3% for lamellar macular holes; 0.1%, 0% and 0% for pseudoholes; 1.1%, 1.9% and 5.5% for macular cysts. None of the participants was diagnosed with a macular hole. The prevalence of epiretinal membranes, vitreomacular traction and macular cysts was higher with age (p < 0.001). Vitreomacular traction and lamellar macular holes were more frequent in women (p < 0.01). DM2 is positively associated [OR = 3.9 (95% CI 2.11–7.22, p < 0.001)] with macular cysts and negatively associated with lamellar macular holes [OR = 0.2 (95% CI 0.04–0.9, p = 0.036)] after adjustment for age and sex. The calculated prevalence of VMI disorders was 15.9%.ConclusionsThe calculated prevalence of VMI disorders in individuals aged between 40 and 75 years is 15.9%. The prevalence depends on age, sex and glucose metabolism status for several types of VMI disorders.

Lamellar Macular Hole: State of the Art

“…The other 2 trials, the Maastricht [23] and Beaver Dam Eye [24] studies, were population-based cohort studies and satisfied the criteria for recruitment to a random sample. The Maastricht study [23], a large observational prospective cohort study, investigated the etiology, complications, and comorbidities of type 2 diabetes mellitus, focusing on the phenotypic aspect of the disease.…”

“…The Maastricht study [23], a large observational prospective cohort study, investigated the etiology, complications, and comorbidities of type 2 diabetes mellitus, focusing on the phenotypic aspect of the disease. The study included 3,451 participants aged 40–75 years who lived in the southern part of the Netherlands.…”

“…The statistical analysis of the data revealed a prevalence of LMH of 1.1% (17 of 1,531 patients) in the subpopulation with normal glucose metabolism, of 0.7% (5 of 401 patients) in the subpopulation with pre-diabetes, and of 0.3% (2 of 728 patients) in the subpopulation affected by type 2 diabetes mellitus. The prevalence of LMH showed no significant correlation with age [23]. …”

“…LMH mainly affects subjects within the age range of 50–70 years [21-24]. According to these 2 studies [23, 24], the prevalence of LMH in the general population ranges from 1.1 to 3.6%, with no significant correlation with gender and age.…”

Incidence of acute postoperative endophthalmitis following macular surgery in France between 2006 and 2016

“…Epiretinal membrane and macular holes are common macular conditions that affect 7% and 0.2%, respectively, of individuals aged over 50 years (Mitchell et al 1997;Liesenborghs et al 2018). In the case of severe visual acuity loss or metamorphopsia, these conditions require a surgical intervention (McDonald et al 1986;Benson et al 2001).…”