Prevalence of oral lichen planus in patients with diabetes mellitus: A cross‐sectional study

Abstract

ObjectivesOral lichen planus, a chronic inflammatory immune disease, occurs in the oral mucosa. We aimed to assess the prevalence and possible influencing factors of oral lichen planus in patients with diabetes mellitus.Subjects and MethodsThis cross‐sectional study involved 525 patients with diabetes mellitus and 525 controls. We collected information on blood glucose level, duration of diabetes, diabetic complications, treatment methods, other systemic diseases and medication history.ResultsOral lichen planus was significantly more prevalent in the diabetes mellitus/type 2 diabetes mellitus group than in the controls (2.3%/2.2% vs. 0.6%, p = 0.019/0.022). There was no significant association between patients with diabetes mellitus with and those without oral lichen planus in age (p = 0.195), sex (p = 0.390), blood glucose level (p = 1), duration of diabetes (p = 0.638), diabetic complications (p = 1), treatment methods (p = 0.962), other systemic diseases (p = 0.891) and medication history (p = 0.848).ConclusionsDiabetes mellitus was associated with oral lichen planus; there was a higher prevalence of oral lichen planus in patients with diabetes mellitus/type 2 diabetes mellitus than in those without diabetes. Oral lichen planus development in patients with diabetes mellitus was not significantly associated with age, sex, blood glucose level, duration of diabetes, diabetic complications, treatment methods, other systemic diseases and medication history.

Risk of Oral Squamous Cell Carcinoma in One Hundred Patients with Oral Lichen Planus: A Follow-Up Study of Umberto I University Hospital of Rome

“…Regarding the clinical type, the majority of OLP patients with DM manifested with the white "reticular" type (8 patients (66.7%)), while the atrophic type was observed in only 4 patients (33.3%). This finding was in line with previous studies, where a higher prevalence of the reticular type was reported among OLP patients with DM [17,18].…”

“…The association between DM and OLP is still controversial in the literature [17]. In our study, a total of twelve OLP patients were found to have DM.…”

“…A recent systematic review evaluating the association between OLP and DM found that there was a moderate association between them (OR = 1.87, 95% CI = 1.57-2.34), and this association was stronger in studies carried out on European populations compared with studies carried out on Asian populations [18]. In addition, the authors of the study found that the association was stronger with type II DM [17,18].…”

Possible interplay of diabetes mellitus and thyroid diseases in oral lichen planus: A pooled prevalence analysis

“…In contrast, patients with DM and/or TD should undergo periodic oral mucosa examinations to rule out OLP. 10 , 11 , 12 Cross-referral of OLP patients seen in oral medicine to endocrine department for investigation and management of comorbidities. The impact that these proposals could have on health outcomes both in one group and another of patients should be analyzed in new specific studies designed for it, which could serve as recommendations to improve and standardize future research.…”

Changes in Lipoprotein Particles in the Blood Serum of Patients with Lichen Planus

“…The most common comorbidities of LP are hepatitis C virus infection (HCV) and thyroid disease [ 2 , 12 ]. Recently, metabolic syndrome (MS), type 2 diabetes (T2D) and dyslipidemia have also been reported to be associated with LP [ 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. Additionally, LP patients have increased risk for cardiovascular diseases [ 20 , 21 ].…”