Background: Diarrhea is the second most common cause of morbidity and mortality among children under 5 years old, following acute respiratory tract infection. Despite that home interventions can prevent 57% of mortality related to diarrhea. However, still mothers’ attitudes towards home-based diarrheal management range from 39-78% as a result of different factors.Objective: This study aimed at assessing attitudes towards home-based management of diarrhea and associated factors among mothers of under-five children attending health care institutions.Methods: An institutional-based cross-sectional study was conducted. Systematic random sampling was used to select study participants. Data were entered using Epidata version 3.1 and exported to SPSS version 25. The result was presented in frequency and percentage using tables and figures. Binary logistic regression was used to analyze the data. Those variables with p-value <0.2 in bivariate were entered in multivariate analysis to avoid confounding variables whereby p-value <0.05 were considered as significantly associated. Result: A total of 422 mothers were surveyed with a 100% response rate. The mean age of the mothers was 33 ±10. Positive mothers’ attitude was 51.9% with 95%CI (46.8, 57.1). Maternal age ranges from 25-35 years (AOR:3.27, 95% CI: 1.72,6.22), 36-45 years (AOR: 8.79, 95%CI: 3.50, 22.11), age >45 years (AOR: 8.00, 95%CI: 2.62, 24.43), being single (AOR 0.18, 95%CI:0.06, 0.56), being divorced (AOR:0.25, 95%CI:0.08,0.81), primary education (AOR: 7.26, 95%CI: 3.62,14,57), Secondary and above (AOR:8.43, 95%CI:3.77,18.82), Daily labor (AOR:5.44, 95%CI:1.19, 24.96), Income level with 1001-3000 ETB and greater or equal to 3001ETB with (AOR:3.14, 95%CI:1.35, 7.29) and (AOR:4.06, 95% CI: 1.71, 9.66) respectively. Knowing about how to prepare ORS (AOR: 6.72, 95%CI: 3.62,12.48) were significantly associated variables with the out came variable in the multivariate regressionConclusion: One in every two mothers had a favorable attitude in this study. Maternal age, marital status, maternal educational status, occupation, and knowing about the preparation of ORS were factors associated with mothers’ attitude. The focus should be made on younger mothers, illiterate, unmarried couples, not knowing how to prepare ORS to boost mothers’ attitude.