Prevalence of oral, skin, and oral and skin lesions of lichen planus in patients visiting a dental school in Southern India

Omal, PM; Jacob, Vimal; Prathap, Akhilesh; Thomas, Nebu George

doi:10.4103/0019-5154.94276

Cited by 31 publications

(47 citation statements)

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“…This was found to be similar to the study done by Omal et al among south Indian population was found to be similar to the present study. 18 Similarly by Mehdipour in their study reported increased prevalence of LP among patients of age group 40 to 60 yrs. 19 Among the patients with metabolic syndrome, maximum number of LP patients belonged to the sixth decade which was 7 (38.88%) of the 18 patients.…”

Section: Agementioning

confidence: 97%

A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

2017

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Background: Lichen planus is an autoimmune, inflammatory papulosquamous disease affecting skin and mucous membrane with a possible association with the parameters of metabolic syndrome.Methods: We carried out a hospital based case control study among patients attending DVL OPD during a period of 1.5 years (January 2015 - May 2016). Study population included 40 cases of LP and 80 age and sex matched controls. Relevant history, clinical examination and blood investigations were done. Diagnosis of MS was made based on IDF criteria.Results: There was no significant association between metabolic syndrome and lichen planus (p=0.292). Although there was higher prevalence of hypertension (47.5% vs. 27.5%, p=0.029), triglyceride level (25% vs. 10%, p=0.030) and low HDLC levels (65% vs. 45%, p=0.039). We could not establish significant association between FBS and waist circumference with LP.Conclusions: Though metabolic syndrome was not significantly associated with LP, its components such as hypertension, triglycerides and low HDLC levels were significantly associated with LP as per the study. Therefore patients with LP need to be screened to rule out each of these parameters to avoid later complications.

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Section: Agementioning

confidence: 97%

A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

2017

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“…Os adultos, especialmente as mulheres (a proporção pode ser tão elevada como 3:1), são os mais acometidos. [6][7][8] O tratamento do LPO é paliativo e indicado apenas nos pacientes sintomáticos.…”

Section: A Organização Mundial De Saúde (Oms) Incluiu O Líquen Plano unclassified

“…O líquen plano oral (LPO) isolado é a forma mais comumente encontrada, enquanto o líquen plano cutâneo (LPC) isolado é a menos frequente [7].…”

Section: -Líquen Planounclassified

“…O LPC comumente envolve as faces flexoras dos antebraços e caracteriza-se por pápulas achatadas eritematosas a violáceas, exibindo discretas linhas brancas entrelaçadas [6]. Os joelhos, o couro cabeludo e as unhas também podem ser envolvidos [7]. O diagnóstico do LPC pode ser feito clinicamente ou por biópsia.…”

Section: -Líquen Planounclassified

“…A expressão dos anticorpos foi avaliada por um índice de positividade (IP) determinado após a contagem de 500 células de cada amostra. Resultados: Verificou-se que o IP (mediana) de P16 em LPC foi o mais elevado (86,59), seguido pelo LPO (20,65), HFO (11,8) e DO (7,85) (p <0,001).…”

Section: Introductionunclassified

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Imunoexpressão de P16, BUB3, SOX4 E KI67 em líquen plano oral, comparação com líquen plano cutâneo, displasia oral e hiperplasia oral

Rosa¹

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AGRADECIMENTOSAos Funcionários do laboratório de Patologia, em especial à querida Tércia Lousa.À Professora Dra. Denise Pinheiro Falcão, pela inestimável ajuda, pelo incentivo, pela paciência e pela presteza inesgotáveis. Sem ela eu não teria chegado até aqui.Aos colegas patologistas, Dr. Luiz Eduardo de Almeida Prado Franceschi, Dr. Alesso Cervantes Sartorelli e Prof. Dr.Florêncio Figueiredo Cavalcanti Neto, pelo apoio fundamental.Às amigas Anna Alice e Maria Rejane, pela ajuda na organização e preparação do material para análise. À Professora Dra. Fabiana Pirani Carneiro, por sua ajuda no laboratório de imunoistoquímica, onde tudo aconteceu. À Professora Dra. Erica Negrini, pelo incentiovo carinhoso e pela ajuda mágica nos momentos mais difíceis.Ao Professor e amigo Rivadávio Fernandes Batista Amorim, pela orientação deste trabalho.Aos meus colegas de pós-graduação, que transformaram um longo período de árdua dedicação em algo prazeroso, em especial à querida Mikaela Kogawa, pelo apoio e incentivo de sempre. À Morena, que nos últimos e mais dramáticos instantes trouxe a tranquilidade preciosa, a força imprescindível, o apoio incondicional e a alegria necessárias para terminar essa pequena obra. P16 can not be considered a reliable marker for malignant transformation in oral lesions. The expression of BUB3 and SOX4 should be further clarified, but they may act as protect factors. More studies should be performed envolving these markers. EPÍGRAFE

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Global Prevalence and Incidence Estimates of Oral Lichen Planus

et al. 2020

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IMPORTANCE Integrated information on the global prevalence and incidence of oral lichen planus (OLP) is lacking.OBJECTIVE To examine the global prevalence and incidence of OLP in a systematic review and meta-analysis.DATA SOURCES A systematic review of population-based studies and clinic-based studies reporting the prevalence and incidence of OLP was performed using 3 electronic medical databases (Cochrane Database of Systematic Reviews, Embase, and MEDLINE) from their inception to March 2019. The search terms included "(lichen planus or LP) and (prevalence or incidence or epidemiology)." No language restriction was applied.STUDY SELECTION Observational descriptive studies investigating the prevalence and incidence of OLP were included.DATA EXTRACTION AND SYNTHESIS Data were extracted by continent, sex, and other characteristics. The risk of bias was assessed by the Joanna Briggs Institute Critical Appraisal Instrument for Studies Reporting Prevalence Data using random-effects models to synthesize available evidence. MAIN OUTCOMES AND MEASURESThe primary outcome was the prevalence (with 95% CIs) of OLP among the overall population and among subgroups. Between-study heterogeneity was assessed using the I 2 statistic. RESULTS Among 46 studies, the overall pooled estimated prevalence of OLP was 0.89% (95% CI, 0.38%-2.05%) among the general population (n = 462 993) and 0.98% (95% CI, 0.67%-1.43%) among clinical patients (n = 191 963). Among the 15 population-based studies, the prevalence of OLP was 0.57% (95% CI, 0.15%-2.18%) in Asia, 1.68% (95% CI, 1.09%-2.58%) in Europe, and 1.39% (95% CI, 0.58%-3.28%) in South America. Among the 31 clinic-based studies, the prevalence was 1.43% (95% CI, 1.12%-1.83%) in Africa, 0.87% (95% CI, 0.61%-1.25%) in Asia, 1.03% (95% CI, 0.51%-2.09%) in Europe, 0.11% (95% CI, 0.07%-0.16%) in North America, and 3.18% (95% CI, 0.97%-9.95%) in South America. The pooled prevalence of OLP by sex was 1.55% (95% CI, 0.83%-2.89%) for women and 1.11% (95% CI, 0.57%-2.14%) for men in the population-based studies and 1.69% (95% CI, 1.05%-2.70%) for women and 1.09% (95% CI, 0.67%-1.77%) for men in the clinic-based studies. In 5 clinic-based studies providing the age distribution of patients with OLP, the prevalence by age was 0.62% (95% CI, 0.33%-1.13%) among patients younger than 40 years and 1.90% (95% CI, 1.16%-3.10%) among patients 40 years and older.CONCLUSIONS AND RELEVANCE This study identified the global prevalence and incidence of OLP in terms of its spatial, temporal, and population distribution. The overall estimated pooled prevalence of OLP was 0.89% among the general population and 0.98% among clinical patients. A higher prevalence of OLP was found in non-Asian countries, among women, and among people 40 years and older. The findings should be considered with caution because of the high heterogeneity of the included studies.

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Prevalence of oral, skin, and oral and skin lesions of lichen planus in patients visiting a dental school in Southern India

Cited by 31 publications

References 1 publication

A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

Imunoexpressão de P16, BUB3, SOX4 E KI67 em líquen plano oral, comparação com líquen plano cutâneo, displasia oral e hiperplasia oral

Global Prevalence and Incidence Estimates of Oral Lichen Planus

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