Prevalence of osteoporotic vertebral fracture among community-dwelling elderly in Shanghai

Gao, Chao; Xu, Yu; Li, Li; Gu, Wenqin; Chun-tao, YI; Gu, Hong-An; Chen, Bihua; Wang, Qingqing; Tang, Feng; Xu, Ju-Liang; Song, Huijiang; Wang, Hui; Wang, Zhiliang; Zhang, Zhen‐Lin

doi:10.1097/cm9.0000000000000332

Cited by 26 publications

(30 citation statements)

References 11 publications

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“…There is evidence that, despite greater soft tissue mass and thickness, obesity is not protective against fracture, particularly at the spine and appendicular skeletal sites [17][18][19]. A recent study in Shanghai, China, reported that the prevalence of vertebral deformity in men was similar to that in women (17% vs. 17.3%) over 60 years [26] and a three-fold higher vertebral fracture prevalence in men has been reported elsewhere [17].…”

Section: Discussionmentioning

confidence: 99%

Adjustment of DXA BMD measurements for anthropometric factors and its impact on the diagnosis of osteoporosis

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Adjustment of DXA BMD measurements for anthropometric factors and its impact on the diagnosis of osteoporosis

et al. 2020

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“…The inclusion criteria were as follows: healthy men and women according to the following excluding criteria. Exclusion criteria in accordance with our previous articles were used to exclude individuals from the study [ 5 , 16 , 19 , 20 ]: (1) serious effects from cerebrovascular disease; (2) other diseases, such as diabetes mellitus, chronic renal disease, chronic liver disease, rheumatoid arthritis or collagen disease, hyperthyroidism, and recent major gastrointestinal disease; (3) evidence of other metabolic or inherited bone diseases; (4) significant diseases of any endocrine organ that would affect bone mass; (5) any neurological or musculoskeletal condition; and (6) any form of calcium and vitamin-D therapy in three months or taking antiosteoporotic drugs (e.g., bisphosphonates, selective estrogen receptor modulators, and calcitonin). Postmenopausal women who had experienced early menopause (before 45 years of age) were excluded.…”

Section: Methodsmentioning

confidence: 99%

“…Our study showed that the prevalence of vertebral fracture was 17.2% among Shanghai community-dwelling elders (over 60 years), 17.0% for males, and 17.3% for females. The prevalence among females increased with age [ 5 ]. The prevalence of osteoporosis in our country has increased over the past 12 years, affecting more than one-third of people aged 50 years and older [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Association of HIVEP3 Gene and Lnc RNA with Femoral Neck Bone Mineral Content and Hip Geometry by Genome-Wide Association Analysis in Chinese People

Wang

et al. 2020

International Journal of Endocrinology

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Purpose. GWAS has successfully located and analyzed the pathogenic genes of osteoporosis. Genetic studies have found that heritability of BMD is 50%–85% while the other half is caused by hip geometric parameters and tissue horizontal characteristics. This study was designed to study the GWAS of osteoporosis in Shanghai Han population. Methods. We collected 1224 unrelated healthy young men (20–40 years old), young women (20–40 years old), and postmenopausal women (over 50 years old) who lived in Shanghai. BMD and hip geometric parameters were measured by dual-energy X-ray absorptiometry. The genomic DNA of peripheral blood was extracted and analyzed by using Illumina Human Asian Screening Array-24 + v 1.0 (ASA) gene chip. Statistical analysis was carried out to evaluate the relationship between these SNPs and BMD and hip geometric parameters. Results. A total of 1155 subjects were included. We found that one SNP rs35282355 located in the human immunodeficiency virus type 1 enhancer-binding protein 3 gene (HIVEP3) and another 25 SNPs located in LINC RNA were significantly correlated with bone mineral content (BMC) in the femoral neck ( P = 2.30 × 10−9, P < 5 × 10−8). We also found that the correlation between SNP rs35282355 and cross-sectional area (CSA) of hip geometry was a significant marginal statistical difference ( P = 5.95 × 10−8). Conclusions. Through this study, we found that HIVEP3 gene and LINC RNA are potentially correlated with femoral neck BMC. These results provide important information for us to further understand the etiology and genetic pathogenesis of osteoporosis. In the future, we will expand the sample size to verify these loci and carry out molecular research.

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“…On the other hand, the prevalence is higher in rural areas of China, at 20.7% and 35.3%, respectively, which may indicate a relatively poor bone health situation of countryside inhabitants. Our former study concentrated on vertebral fractures in approximately 15,000 Shanghai community-dwelling elderly individuals and found a prevalence of 17.0% for males and 17.3% for females, and rural areas also obtained a higher prevalence than downtown areas in Shanghai ( 4 ). Bone mineral density (BMD) measured by dual energy X-ray absorptiometry (DXA) remains the gold diagnostic standard for osteoporosis according to a report about the assessment of fracture risk and its application to screening for postmenopausal osteoporosis from the World Health Organization in 1994.…”

Section: Introductionmentioning

confidence: 95%

The Assessment of the Osteoporosis Self-Assessment Tool for Asians and Calcaneal Quantitative Ultrasound in Identifying Osteoporotic Fractures and Falls Among Chinese People

Gao

Song

Chen³

et al. 2021

Front. Endocrinol.

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The lack of DXA has made the diagnosis and treatment of osteoporosis extremely difficult in the vast rural areas of China, which has the largest population with high risks of osteoporosis. The aims of this cross-sectional study were to evaluate the association between the osteoporosis self-assessment tool for Asians (OSTA) and calcaneus quantitative ultrasound (QUS) in populations residing in Shanghai, China, and their assessment in predicting osteoporotic fractures and falls. A population of 12,033 participants, including 1272 males (average age 68.3 ± 9.8 years, range 28–100 years) and 10,761 females (average 56.8 ± 11.4 years, range 23–99 years), was gathered. OSTA and calcaneus QUS (Sonost 2000, OsteoSys) values were measured. Spearman’s correlation and Cohen’s kappa were used to determine the association and agreement between the OSTA and QUS. Receiver operating characteristic (ROC) curves were adapted to assess the performance and optimal cutoff values for the OSTA and QUS in osteoporotic fracture and fall screening. In total, the prevalence of osteoporotic fractures (low-trauma fractures including fractures of the spine, hip, forearm, humerus and ribs) was 15.2% in women, and 17.7% reported a history of falls (falling from standing height more than once in the past year). The percentages of men with the same history were 8.4% and 11.7%, respectively. The association between the OSTA and QUS was found to be rs = 0.393, κ = 0.137, p < 0.001. The OSTA (cutoff < −1) revealed an area under ROC curve (AUC) of 0.590 in identifying female individuals with moderate or high risk of osteoporosis defined by QUS (T-score < −1). The QUS T-score lower than −1.55 or −1.40 in postmenopausal women may lead to an increased risk of falls or osteoporotic fractures, respectively. The agreement between QUS and the OSTA seemed to be limited in determining individuals at risk of osteoporosis. Measuring bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) may still be necessary in the clinical diagnosis of osteoporosis. OSTA and QUS T-scores less than the respective cutoff values may indicate an increased risk of osteoporotic fractures and falls that individual should be further treated and screened by DXA.

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Prevalence of osteoporotic vertebral fracture among community-dwelling elderly in Shanghai

Abstract: Supplemental Digital Content is available in the text

Cited by 26 publications

References 11 publications

Adjustment of DXA BMD measurements for anthropometric factors and its impact on the diagnosis of osteoporosis

Adjustment of DXA BMD measurements for anthropometric factors and its impact on the diagnosis of osteoporosis

Association of HIVEP3 Gene and Lnc RNA with Femoral Neck Bone Mineral Content and Hip Geometry by Genome-Wide Association Analysis in Chinese People

The Assessment of the Osteoporosis Self-Assessment Tool for Asians and Calcaneal Quantitative Ultrasound in Identifying Osteoporotic Fractures and Falls Among Chinese People

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