Prevalence of oxacillin- and multidrug-resistant staphylococci in clinical samples from dogs: 1,772 samples (2001–2005)

Jones, Rebekah D.; Kania, Stephen A.; Rohrbach, Barton W; Frank, Linda A.; Bemis, David A.

doi:10.2460/javma.230.2.221

Cited by 118 publications

(130 citation statements)

References 31 publications

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“…Como o aumento da prevalência de MRSP em cães com pioderma superficial é um acontecimento relativamente recente (Jones et al 2007, Loeffler et al 2007, Lucia et al 2011, torna-se importante a avaliação local e periódica dos perfis de suscetibilidade. Como já mencionado, as cefalosporinas são os antimicrobianos de primeira escolha e utilizados com maior frequência no tratamento dessa dermatopatia, entretanto, frente a infecções cutâneas por MRSP, as cefalosporinas deixam de constituir opções terapêuticas, o que restringe a seleção dos fármacos.…”

Section: Resultsunclassified

“…Dentre os multirresistentes, em 24 verificou--se resistência a três classes de antimicrobianos, em 11 a quatro classes e um isolado frente a cinco classes (Quadro 1). Embora a multirresistência tenha íntima associação com estafilococos resistentes à meticilina em humanos e animais, esse padrão pode ocorrer na ausência de resistência à oxacilina (Jones et al 2007), fato observado neste estudo, no qual cinco dos 36 isolados multirresistentes, também foram resistentes à oxacilina. Onuma et al (2011) relataram expressiva elevação na prevalência de multirresistência entre S. pseudintermedius isolados de cães com pioderma no Japão, entre 1999 e 2009.…”

Section: Resultsunclassified

“…multirresistentes e resistentes à meticilina (MRS) em medicina veterinária (Jones et al 2007, Duijkeren et al 2011, Nienhoff et al 2011, Bond & Loeffler 2012. A emergência desses patógenos, isolados principalmente de lesões cutâ-neas, otites e infecções pós-cirúrgicas, implica em um grave problema devido à dificuldade no tratamento e ao considerável potencial zoonótico (Duquette & Nuttall 2004, Guardabassi et al 2008).…”

Section: Introductionunclassified

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Suscetibilidade antimicrobiana de Staphylococcus spp. isolados de cães com pioderma superficial

et al. 2014

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Foram obtidas 154 amostras de lesões cutâneas de cães com pioderma superficial atendidos no Serviço de Dermatologia Veterinária do Hospital Veterinário Universitário (HVU) da Universidade Federal de Santa Maria (UFSM), com o objetivo de determinar a suscetibilidade antimicrobiana de isolados de Staphylococcus spp. e avaliar a presença de multirresistência. Após isolamento e identificação, as cepas foram submetidas ao teste de sensibilidade aos antimicrobianos, cujos resultados evidenciaram menores percentuais de resistência à associação amoxicilina e ácido clavulânico (1,9%), cefadroxil (1,9%), cefalexina (1,9%) e vancomicina (0,6%). Os maiores percentuais de resistência foram frente à amoxicilina (60,4%) e penicilina G (60,4%). A multirresistência foi detectada em 23,4% e a resistência à meticilina em 5,8% das amostras. Pode-se concluir que os isolados de Staphylococcus spp. apresentam elevada suscetibilidade aos antimicrobianos comumente utilizados no tratamento dos piodermas superficiais em cães atendidos no HVU-UFSM, como a cefalexina e a amoxicilina associada ao ácido clavulânico, confirmando a eleição desses fármacos para o tratamento de cães com esta afecção. A suscetibilidade diminuída das cepas frente às fluoroquinolonas, também recomendadas pela literatura para o tratamento de pioderma, permite sugerir que estes fármacos não devem mais ser considerados na seleção empírica. A identificação de Staphylococcus spp. multirresistentes na população canina estudada justifica análises bacteriológicas periódicas e regionais de lesões cutâneas de cães com pioderma superficial, a fim de minimizar a seleção de bactérias resistentes, possíveis falhas terapêuticas e também motiva a antimicrobianoterapia prudente.

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Section: Resultsunclassified

Section: Introductionunclassified

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Suscetibilidade antimicrobiana de Staphylococcus spp. isolados de cães com pioderma superficial

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“…In antimicrobial susceptibility interpretation, the fact that methicillin resistance is mediated by mecA gene, that confers resistance to all β-lactam antibiotics, should be taken into account, regardless of the in vitro results (Jones et al, 2007). The same applies to macrolides because of their cross-resistance (Ganiere et al, 2005).…”

Section: Methicillin-resistant S Pseudinter-medius (Mrsp)mentioning

confidence: 99%

Ever-increasing emergence of multi-drug resistant Staphylococcus pseudintermedius in the dog and its zoonotic potentials

Papadogiannakis

Velonakis

Vatopoulos

2018

J Hellenic Vet Med Soc

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ABSTRACT. Methicillin-resistant Staphylococcus pseudintermedius (MRSP) has emerged as an important pathogen in the dog over the past 10 years with an ever increasing incidence worldwide. This review focuses mainly on the epidemiology and detection of MRSP, emphasizing on the interpretation and pitfalls of screening laboratory tests and antimicrobial susceptibility tests. Risk factors for colonization and infection with MRSP and molecular analysis of the dominant clonal lineages are also described. The zoonotic potential and worldwide epidemiology of multidrug resistant Staphylococcus pseudintermedius (MDRSP) are presented. Finally, control options for the colonization of healthy dogs as well as infection by MRSP and MDRSP are described emphasizing on the indications for bacterial culture and susceptibility testing and the principles of topical therapy which may prove to be the sole effective treatment in several canine pyoderma cases.

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“…For example, in the Netherlands, there was an increase from 0.9% in 2004 to 7% in data published in 2016. [5][6][7][8][9][10][11][12][13] Vanessa Schmidt concluded that MDR strains were common in the population studied. It is increasingly important to obtain bacterial cultures before treatment.…”

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confidence: 96%

Resisting the resistance. Is there progress in maintaining antimicrobial efficacy?

Lloyd

Varjonen

2017

Advances in Veterinary Dermatology

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(UK) discussed the major health threat caused by multiple drug resistance affecting both human and animal welfare, and the anticipation there will be limited future availability of new antibiotics, particularly in veterinary medicine. She briefly outlined antimicrobial treatment history, from the recognition of the importance of hand hygiene, to the recent golden era of antibiotic availability and efficacy, to the current 'period of disenchantment'; a time when antibiotics are starting to be of limited benefit due to increasing development of resistance.1 She then discussed the main pathogens of concern in human medicine, including Gram-negative organisms, and compared that to current veterinary concerns. In her practice, Vanessa Schmidt sees methicillinresistant Staphylococcus pseudintermedius (MRSP) as the greatest concern, but also methicillin-resistant Staphylococcus aureus and Staphylococcus schleiferi (MRSA and MRSS). Multidrug resistance (MDR) is also emerging in Gram-negative bacteria such as Escherichia coli, Pseudomonas, Proteus, Klebsiella and Acinetobacter spp. from cases of deep pyoderma. Multidrug-resistant enterococci are also becoming a concern.Vanessa Schmidt emphasized that it is important for clinicians to have knowledge of the local and regional antimicrobial resistance situation to help them in empirical clinical decision-making and also to be aware of when an empirical choice would be less appropriate. She presented current data and regional patterns for antimicrobial resistance in the UK. Nationwide data can be accessed online on Pet Resist.a This website provides antimicrobial resistance data from laboratory submissions to IDEXX UK, shown plotted on a map based on where submissions originate. The data lack information indicating from which body regions samples were taken, and on the numbers of isolates the percentages are based upon, but still provide updated information on regional resistance patterns. Data from a study conducted in Liverpool were presented. 2This laboratory-based study analysed S. pseudintermedius data from submissions to the university veterinary laboratory in Liverpool. Bacterial culture results were examined over time, and the site of infection was recorded. The data showed a significant increase in resistance over the past 5 years to clindamycin, gentamicin and fluoroquinolones, as well as MDR. Soft tissueand skin-derived isolates were more resistant than isolates from urine. These results correlated with other studies.3,4 Risk factors for MRSP have been reported to be chronic skin infections, multiple hospital visits and the use of broad-spectrum antibiotics.Oxacillin (methicillin) resistance between 2004 and 2015 was also reviewed in Liverpool. Cases of MRSP, which were first seen in 2007, have since increased year by year. This correlates with international data. The methicillin-sensitive S. pseudintermedius (MSSP) strains showed a high level of clindamycin resistance. The level of resistance to clindamycin in this study was higher when compared to levels reporte...

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Prevalence of oxacillin- and multidrug-resistant staphylococci in clinical samples from dogs: 1,772 samples (2001–2005)

Abstract: Veterinarians should be aware of the potential for empiric drug treatment failures in instances where Staphylococcus spp infections are common (eg, pyoderma). Judicious use of bacterial culture and susceptibility testing is recommended.

Cited by 118 publications

References 31 publications

Suscetibilidade antimicrobiana de Staphylococcus spp. isolados de cães com pioderma superficial

Suscetibilidade antimicrobiana de Staphylococcus spp. isolados de cães com pioderma superficial

Ever-increasing emergence of multi-drug resistant Staphylococcus pseudintermedius in the dog and its zoonotic potentials

Resisting the resistance. Is there progress in maintaining antimicrobial efficacy?

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