Prevalence of Oxacillin Resistance in
            <i>Staphylococcus aureus</i>
            among Inpatients and Outpatients in the United States during 2000

Jones, Mark; Mayfield, David C.; Thornsberry, Clyde; Karlowsky, James A.; Sahm, Daniel F.; Peterson, Dan

doi:10.1128/aac.46.9.3104-3105.2002

Cited by 35 publications

(22 citation statements)

References 12 publications

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“…TSN is an electronic repository of susceptibility test results collected from more than 300 microbiology laboratories in the United States, representing a national sample of isolates tested for resistance. Laboratories were selected to be geographically and demographically representative of hospital and patient characteristics (bed size, age, race, and sex) in each of the nine U.S. Census Bureau regional divisions (13,14). Testing of isolates occurs on-site as part of the routine diagnostic testing for susceptibility to different antibiotic agents using standards established by the Clinical and Laboratory Standards Institute (CLSI).…”

Section: Datamentioning

confidence: 99%

Trends in Antibiotic Resistance in Coagulase-Negative Staphylococci in the United States, 1999 to 2012

May

Klein

Rothman

et al. 2014

Antimicrob Agents Chemother

101

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dCoagulase-negative staphylococci (CoNS) are important bloodstream pathogens that are typically resistant to multiple antibiotics. Despite the concern about increasing resistance, there have been no recent studies describing the national prevalence of CoNS pathogens. We used national resistance data over a period of 13 years (1999 to 2012) from The Surveillance Network (TSN) to determine the prevalence of and assess the trends in resistance for Staphylococcus epidermidis, the most common CoNS pathogen, and all other CoNS pathogens. Over the course of the study period, S. epidermidis resistance to ciprofloxacin and clindamycin increased steadily from 58.3% to 68.4% and from 43.4% to 48.5%, respectively. Resistance to levofloxacin increased rapidly from 57.1% in 1999 to a high of 78.6% in 2005, followed by a decrease to 68.1% in 2012. Multidrug resistance for CoNS followed a similar pattern, and this rise and small decline in resistance were found to be strongly correlated with levofloxacin prescribing patterns. The resistance patterns were similar for the aggregate of CoNS pathogens. The results from our study demonstrate that the antibiotic resistance in CoNS pathogens has increased significantly over the past 13 years. These results are important, as CoNS can serve as sentinels for monitoring resistance, and they play a role as reservoirs of resistance genes that can be transmitted to other pathogens. The link between the levofloxacin prescription rate and resistance levels suggests a critical role for reducing the inappropriate use of fluoroquinolones and other broad-spectrum antibiotics in health care settings and in the community to help curb the reservoir of resistance in these colonizing pathogens.

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Section: Datamentioning

confidence: 99%

Trends in Antibiotic Resistance in Coagulase-Negative Staphylococci in the United States, 1999 to 2012

May

Klein

Rothman

et al. 2014

Antimicrob Agents Chemother

101

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“…nmMRSA strains are generally believed to have originated in the community environment, but they may also include nonmultiresistant sporadic hospital strains that have been taken into the community (3). In addition, the spread of strains associated with the health care setting into the community has been documented (9,19,60). Both the emergence of novel community-acquired strains and the spread of health care setting-associated strains of MRSA to the community are causes for public health concern.…”

mentioning

confidence: 99%

Genetic Diversity among Community Methicillin-Resistant Staphylococcus aureus Strains Causing Outpatient Infections in Australia

et al. 2004

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“…In the United States, the percentage of hospitals with reported cases of MRSA has risen from 2,4% in 1975 to 29% in 1991 8 and 46% in 2000. 9 Hospitals in the Netherlands have a significantly lower prevalence of methicillin resistance.…”

Section: Low Prevalence Of Mrsa In the Netherlandsmentioning

confidence: 99%

Successful control of MRSA spread in the Netherlands

Dekker

Broek

2010

Int. j. infect. control

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Due to intensive use of antibiotics, strains of Staphylococcus aureus have acquired resistance against several antibiotics. Methicillin resistant strains of S. aureus are becoming increasingly frequent worldwide and are associated with higher mortality, longer admissions and larger hospital expenses. In response to this worldwide trend, Dutch hospitals have adopted the search-and-destroy policy. In accordance to this policy, patients with MRSA are rapidly isolated and treated until the infection or colonization has been eradicated. These measures, together with the culturally determined low use of antibiotics in the Netherlands, have lead to one of the lowest prevalences worldwide. This article discusses the most important measures in the Dutch protocol.

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Prevalence of Oxacillin Resistance in Staphylococcus aureus among Inpatients and Outpatients in the United States during 2000

Cited by 35 publications

References 12 publications

Trends in Antibiotic Resistance in Coagulase-Negative Staphylococci in the United States, 1999 to 2012

Trends in Antibiotic Resistance in Coagulase-Negative Staphylococci in the United States, 1999 to 2012

Genetic Diversity among Community Methicillin-Resistant Staphylococcus aureus Strains Causing Outpatient Infections in Australia

Successful control of MRSA spread in the Netherlands

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