Prevalence of Pain Reporting and Associated Health Outcomes Across Emerging Markets and Developed Countries

Goren, Amir; Mould-Quevedo, J; DiBonaventura, Marco

doi:10.1111/pme.12542

Cited by 27 publications

(38 citation statements)

References 38 publications

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“…Our findings on the reporting of pain/discomfort coincide with those of earlier multi-country studies that showed a tendency towards lower rates or intensity of self-reported pain in Japan than in other countries [7, 8, 27]. Despite lower rates of self-reported pain/discomfort in Japan, we found that this was the most important dimension in explaining respondents’ self-reported EQ-5D-3L VAS scores.…”

Section: Discussionsupporting

confidence: 88%

“…With regard to pain reporting, there is evidence that this can vary quite widely across countries; for example, the results of a survey published in 2014 showed that pain reporting and treatment rates were lower in China (6.2% and 28.3%, respectively) and Japan (4.4% and 26.3%, respectively) than in the other countries involved (≥14.3% and 35.8%, respectively) [7]. Substantial variations between countries in the rate of pain reporting have also been reported in primary care [8] and among patients with cancer [9].…”

Section: Introductionmentioning

confidence: 99%

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An exploration of differences between Japan and two European countries in the self-reporting and valuation of pain and discomfort on the EQ-5D

et al. 2017

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PurposeTo investigate the systematic differences in the self-reporting and valuation of overall health and, in particular, pain/discomfort between three countries (England/UK, Japan, and Spain) on the EQ-5D.MethodsExisting datasets were used to explore differences in responses on the EQ-5D descriptive system between Japan (3L and 5L), the UK (3L), England (5L), and Spain (5L), particularly on the dimension of pain/discomfort. The role of different EQ dimensions in determining self-reported overall health scores for the EuroQol visual analog scale (EQ-VAS) was investigated using ordinary least squares regression. Time trade-off (TTO) results from Japanese and UK respondents for the EQ-5D-3L as well as Japanese and English respondents for the EQ-5D-5L were compared using t tests.ResultsFor the EQ-5D-3L, a higher percentage of respondents in Japan than in the UK reported ‘no pain/discomfort’ (81.6 vs 67.0%, respectively); for the EQ-5D-5L, the proportions were 79.2% in Spain, 73.2% in Japan, and 63–64% in England, after adjusting for age differences in samples. The ‘pain/discomfort’ dimension had the largest impact on respondents’ self-reported EQ-VAS only for EQ-5D-3L in Japan. Using the EQ-5D-3L, Japanese respondents were considerably less willing to trade off time to avoid pain/discomfort than the UK respondents; for example, moving from health state, 11121 (some problems with pain/discomfort) to 11131 (extreme pain/discomfort) represented a decrement of 0.65 on the observed TTO value in the UK compared with 0.15 in Japan. Using the EQ-5D-5L, Japanese respondents were also less willing to trade off time to avoid pain/discomfort than respondents in England; however, the difference in values was much smaller than that observed using EQ-5D-3L data.ConclusionsThis study provides evidence of between-country differences in the self-reporting and valuation of health, including pain/discomfort, when using EQ-5D in general population samples. The results suggest a need for caution when comparing or aggregating EQ-5D self-reported data in multi-country studies.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

An exploration of differences between Japan and two European countries in the self-reporting and valuation of pain and discomfort on the EQ-5D

et al. 2017

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“…In addition, among Japanese physicians who had previously treated fibromyalgia patients, less than half (44.2%) self-reported wanting to accept more patients with this chronic pain condition 35. Furthermore, cross-national data showed that Japan had the lowest rate of pain reported (4.4%) and treated (26.3%), compared to other developed countries, including the USA (23.8% experienced pain and 40.1% treated) and Europe (including the UK, France, Germany, Italy, and Spain; 20.2% experienced pain and 47.0% treated) 36. Therefore, underdiagnosis and low acceptance of patients with fibromyalgia by physicians coupled with low pain reporting among patients may hinder the ability of Japanese patients to obtain a diagnosis and receive treatment for fibromyalgia.…”

Section: Discussionmentioning

confidence: 99%

Humanistic and economic burden of fibromyalgia in Japan

Lee

Ebata

Hlavacek

et al. 2016

JPR

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PurposeThe aim of this study was to examine the health and economic burden associated with fibromyalgia among adults in Japan.Materials and methodsData from the 2011–2014 Japan National Health and Wellness Survey (n=115,271), a nationally representative survey of adults, were analyzed. The greedy matching algorithm was used to match the respondents who self-reported a diagnosis of fibromyalgia with those not having fibromyalgia (n=256). Generalized linear models, controlling for covariates (eg, age and sex), examined whether the respondents with fibromyalgia differed from matched controls based on health status (health utilities; Mental and Physical Component Summary scores from Medical Outcomes Study: 12-item Version 2 and 36-item Version 2 Short Form Survey), sleep quality (ie, sleep difficulty symptoms), work productivity (Work Productivity and Activity Impairment Questionnaire – General Health Version 2.0), health care resource use, and estimated annual indirect and direct costs (based on published annual wages and resource use events) in Japanese yen (¥).ResultsAfter adjustment for covariates, respondents with fibromyalgia relative to matched controls scored significantly lower on health utilities (adjusted means =0.547 vs 0.732), Mental Component Summary score (33.15 vs 45.88), and Physical Component Summary score (39.22 vs 50.81), all with P<0.001; these differences exceeded the clinically meaningful levels. In addition, those with fibromyalgia reported significantly poorer sleep quality than those without fibromyalgia. Respondents with fibromyalgia compared with those without fibromyalgia experienced significantly more loss in work productivity and health care resource use, resulting in those with fibromyalgia incurring indirect costs that were more than twice as high (adjusted means =¥2,826,395 vs ¥1,201,547) and direct costs that were nearly six times as high (¥1,941,118 vs ¥335,140), both with P<0.001.ConclusionJapanese adults with fibromyalgia experienced significantly poorer health-related quality of life and greater loss in work productivity and health care use than those without fibromyalgia, resulting in significantly higher costs. Improving the rates of diagnosis and treatment for this chronic pain condition may be helpful in addressing this considerable humanistic and economic burden.

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“…The mechanisms involve inflammatory responses, peripheral and central sensitization, neuronal plasticity changes, and activation of spinal gliacytes [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Spinal Heme Oxygenase-1 (HO-1) Exerts Antinociceptive Effects Against Neuropathic Pain in a Mouse Model of L5 Spinal Nerve Ligation

Liu

Zhang²,

Zhang

et al. 2015

Pain Med

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Prevalence of Pain Reporting and Associated Health Outcomes Across Emerging Markets and Developed Countries

Cited by 27 publications

References 38 publications

An exploration of differences between Japan and two European countries in the self-reporting and valuation of pain and discomfort on the EQ-5D

An exploration of differences between Japan and two European countries in the self-reporting and valuation of pain and discomfort on the EQ-5D

Humanistic and economic burden of fibromyalgia in Japan

Spinal Heme Oxygenase-1 (HO-1) Exerts Antinociceptive Effects Against Neuropathic Pain in a Mouse Model of L5 Spinal Nerve Ligation

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