Prevalence of papillomavirus in Brazil: a systematic review protocol

Colpani, Verônica; Bidinotto, Augusto Bacelo; Falavigna, Maicon; Giozza, Silvana Pereira; Benzaken, Adèle Schwartz; Pimenta, Cristina; Maranhão, Ana Goretti Kalume; Domingues, Carla Magda Allan Santos; Hammes, Luciano Serpa; Wendland, Eliana Márcia

doi:10.1136/bmjopen-2016-011884

Cited by 15 publications

(16 citation statements)

References 15 publications

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“…We show a high prevalence of HPV in cervical tumor samples of women resident in the Northeast of Brazil. HPV 16 and 18 were the most common subtypes, similar to other studies carried out in Brazil (14)(15)(16)(17).…”

Section: Discussionsupporting

confidence: 88%

HPV 18 Variants in Women with Cervical Cancer in Northeast Brasil

Santos¹,

Cunha²,

Batista³

et al. 2020

Preprint

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Abstract Background: Human Papillomavirus (HPV) is the main etiological factor for the development of cervical cancer. HPV 18 is the second most frequent, accounting for up to 65% of all cases. HPV intratypic variation may influence the potential for progression to invasive cancer.The aim of this study was to evaluate the prevalence of human papillomavirus 18 intratypic variants in cervical cancer samples from women in the Northeast of Maranhão. Methods: The study was composed of 118 women over 18 years of age with a diagnosis of cervical cancer. Tumor fragments were collected and subjected to DNA extraction and Polymerase Chain Reaction (PCR) for HPV detection using the PGMY09/11 and GP+5/6 primers. Positive samples were submitted to automated sequencing for viral genotyping. To determine the HPV 18 lineages, positive samples were submitted to PCR, using specific primers to amplify the LCR and E6 regions of HPV 18 virus. Results: HPV was present in 88 women (73.3%), and HPV 16 was the most prevalent (48/54%), followed by HPV 18 (12/13.6%). Histologically, squamous cell carcinoma was predominant (79.1%). Among the HPV 18 variants identified, 10 (80%) belonged to lineage A, and sublineages A1, A2, A3, and A4. HPV 18 B variant (2/29%) was also detected, with the sublineages B1 and B2. In this study, the C variant was not found. There was no statistically significant association between the HPV 18 lineages found and sociodemographic and lifestyle variables (p > 0.05). Conclusions: Women with cervical cancer are associated with a higher frequency of HPV 16 and 18 in the Northeast region of Brazil, with a high prevalence of the lineage A among women with HPV 18.

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Section: Discussionsupporting

confidence: 88%

HPV 18 Variants in Women with Cervical Cancer in Northeast Brasil

Santos¹,

Cunha²,

Batista³

et al. 2020

Preprint

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“…This review has been registered on PROSPERO under protocol number CRD42016032751. This protocol has also been published in a peer reviewed open access journal [10].…”

Section: Methodsmentioning

confidence: 99%

“…We performed the search of the following databases through December 28, 2018 [10]: EMBASE, LILACS, MEDLINE, Web of Science and SciELO using terms as "human papillomavirus", "HPV", "prevalence" and "Brazil" (S1 Appendix); we also scanned the reference lists of identified publications for additional studies. Brazilian specialists in the field were contacted to identify unpublished and ongoing studies and we used the website "bancodeteses.capes.gov.…”

Section: Searchmentioning

confidence: 99%

Prevalence of human papillomavirus (HPV) in Brazil: A systematic review and meta-analysis

et al. 2020

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This study aimed to estimate the prevalence of genital, anal and oral HPV infection in Brazil through systematic review and meta-analysis. Methods We searched EMBASE, LILACS, MEDLINE, Web of Science and SciELO from inception to December 2018. Original research articles that assessed the prevalence of genital (i.e., cervical, penile), anal and oral HPV infection in Brazil were selected in pairs by independent authors. No sex, age, HPV vaccination, language or date restrictions were applied. HPV prevalence was estimated and stratified according to risk factors population and by geographic area throughout the country. The study prevalence was pooled using a random effects model. Analysis was performed using R (version 3.5.2), packages meta version 4.9-4 and metaphor 2.0-0. This review is registered on PROSPERO under protocol number CRD42016032751. Results We identified 3,351 references. After the screening process, 139 of them were eligible for this systematic review (57,513 total participants). Prevalence of cervical HPV was 25.41% (95% CI 22.71-28.32). Additionally, prevalence was 36.21% (95% CI 23.40, 51.33) in the penile region, 25.68% (95%CI 14.64, 41.04) in the anal region, and 11.89% (95%CI 6.26, 21.43) in the oral region. Subgroup analysis showed prevalence in each anatomic site was higher in high-risk populations. Conclusion The prevalence of HPV is high in the Brazilian population and varies by population risk and anatomic body site, with lower rates in the oral cavity compared to that in the cervical, penile

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“…The most common benign genital HPV infection is genital warts, caused in about 90% of the cases by nononcogenic HPV types such as 6 and 11. HPV infection is detected for more than 90% of the cases of cervical cancer [3,4].…”

Section: Epidemiologymentioning

confidence: 99%

“…The prevalence of HPV infection is estimated currently at 10-15%, with substantial regional variation [4]. The most common benign genital HPV infection is genital warts, caused in about 90% of the cases by nononcogenic HPV types such as 6 and 11.…”

Section: Epidemiologymentioning

confidence: 99%

Anogenital HPV

Aşkın¹

2017

Fundamentals of Sexually Transmitted Infections

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Human papilloma virus (HPV) is the most common sexually transmited infection in the world. HPV is associated with various oral, genital and cutaneous conditions, both benign and malignant. HPV infection can be asymptomatic, but it may persist and cause lesions such as warts, dysplasia and cancers depending on low or high risk type of HPV infection. Anogenital warts are the most common clinical presentation of HPV infection. Despite the high incidence of HPV infections, vaccines, precaution methods and treatments are still maters of debate.

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Prevalence of papillomavirus in Brazil: a systematic review protocol

Cited by 15 publications

References 15 publications

HPV 18 Variants in Women with Cervical Cancer in Northeast Brasil

HPV 18 Variants in Women with Cervical Cancer in Northeast Brasil

Prevalence of human papillomavirus (HPV) in Brazil: A systematic review and meta-analysis

Anogenital HPV

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