Prevalence of parent-reported immediate hypersensitivity food allergy in Chilean school-aged children

Hoyos-Bachiloglu, Rodrigo; Ivanovic-Zuvic, Danisa; Álvarez, Juan R Urrego; Linn, Katherina; Thone, Natalie; Paul, Megan; Borzutzky, Arturo

doi:10.1016/j.aller.2013.09.006

Cited by 47 publications

(54 citation statements)

References 21 publications

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“…IgE-mediated FA has been previously identified as the main cause of anaphylaxis during childhood 18,19 . In this study, 40% of the patients had a history compatible with anaphylaxis, which is in line with previously obtained data 12 . This indicates that the anaphylaxis incidence in our population is frequent and is an important manifestation of IgE-mediated FA.…”

Section: Discussionsupporting

confidence: 93%

Caracterización clínica de pacientes chilenos con alergia alimentaria mediada por IgE

Feuerhake

Aguilera-Insunza

Morales

et al. 2018

Rev. chil. pediatr.

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Background: Food allergy (FA) is an entity of high and growing prevalence, which can be mediated by IgE or cellular immunity. It can have a wide range of symptoms and be triggered by multiple food antigens, which vary in different geographical areas. Objectives: To describe clinical characteristics of Chilean patients with IgE-mediated FA. Patients and Method: Retrospective review of patients with IgE-mediated FA treated at a tertiary healthcare center in Santiago, Chile, between 2006 and 2016. Demographic characteristics, clinical manifestations, and trigger foods were evaluated. Results: A total of 282 patients diagnosed with IgE-mediated FA were included. 89% had FA onset before 18 years of age and most of these before one year of age (median of age: one year; range: one month-55 years). The most common clinical manifestations were hives, angioedema, dyspnea, and vomiting. 40% had symptoms compatible with anaphylaxis. The foods most frequently involved were egg, cow's milk, peanut, shellfish, walnut, tomato, wheat, avocado, fish, and legumes. Egg, cow's milk, and peanut allergies were the most frequent at pediatric age, while seafood allergy was the most frequent among adults. Conclusion: Foods causing IgE-mediated FA in Chile were similar to those described in other countries, although the frequency of tomato and avocado allergy, which are unusual in international series, stands out. Anaphylaxis incidence was high, emphasizing the need for epinephrine autoinjectors in Chile.

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Section: Discussionsupporting

confidence: 93%

Caracterización clínica de pacientes chilenos con alergia alimentaria mediada por IgE

Feuerhake

Aguilera-Insunza

Morales

et al. 2018

Rev. chil. pediatr.

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“…Este resultado no es comparable con otros realizados en Latinoamérica debido a que solo se ha reportado la prevalencia de AA, mediante auto reporte, en la población general de adolescentes [9,10]. Mientras que los estudios que aplican métodos como el test cutáneo han sido ejecutados en poblaciones de adolescentes con enfermedades alérgicas, motivo por el que tampoco son comparables, debido a que en este último grupo la prevalencia de AA es mayor.…”

Section: Discussionunclassified

“…Hogar con "pobreza" carece uno o más de los accesos relacionados con vivienda, educación, salud o servicios básicos [10]. Categorías 0= Ausencia de pobreza 1= Pobreza…”

Section: Estatus Socio Económicounclassified

“…Los estudios de la región han identificado AA en la población general de adolescentes por medio de un auto reporte, indicando prevalencias entre el 5 y 12 %, para edades entre 5 a 16 años [9,10]. Otro estudio latinoamericano ha determinado el 13.5 % de sensibilidad a los alimentos, en adolescentes entre 12 a 17 años con enfermedades alér-gicas, al aplicarles test cutáneo [11].…”

Section: Introductionunclassified

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Estudio Transversal: Factores de Riesgo para Alergia Alimentaria en Adolescentes de Cuenca y Santa Isabel, Ecuador

et al. 2017

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MÉTODO:Se realizó un estudio transversal en 1508 adolescentes de Cuenca (n=1008) y Santa Isabel (n=500) entre julio de 2013 y julio de 2014. Para determinar alergia alimentaria y sus factores de riesgo se aplicaron cuestionarios de autoreporte y de necesidades básicas insatisfechas, excepto para sensibilización a aeroalérgenos. Este factor de riesgo fue establecido por test cutáneo. Se emplearon modelos de regresión lineal para determinar las asociaciones entre alergia alimentaria y factores de riesgo. RESULTADOS:La prevalencia de alergia alimentaria (síntomas de alergia alimentaria autoreportada más test cutáneo positivo al menos a un alimento), para 1411 participantes con información completa, fue de 2.34 %; no se observó diferencias estadísticamente significativas entre las áreas de estudio (Cuenca: 2.31 % vs. Santa Isabel: 2.39 %; p: > 0.05). La rinoconjuntivitis fue el único factor de riesgo asociado con la alergia alimentaria. Los adolescentes que reportaron síntomas de rinoconjuntivitis fueron 5.4 % más propensos a presentar alergia alimentaria que reportaron (p: < 0.001). Ninguna otra interacción persistió estadísticamente significativa en el modelo de regresión lineal completo por lo que ningún resultado fue estratificado por cantón. CONCLUSIONES:La alergia alimentaria determinada por auto reporte y test cutáneo fue prevalente en los adolescentes de Cuenca y Santa Isabel. Para este grupo la rinoconjuntivitis fue el único factor de riesgo relacionado con alergia alimentaria, denotando una predisposición genética a presentar enfermedades alérgicas. La rinoconjuntivitis incrementó un 5.4 % la probabilidad de padecer alergia alimentaria para los adolescentes de las regiones estudiadas. PALABRAS CLAVES ABSTRACT Cross-Sectional Study: Risk Factors for Food Allergy in Adolescents from Cuenca and Santa Isabel, Ecuador BACKGROUND: Food allergy in adolescents has been widely associated with risk factors. the aim of this investigation was determined, among adolescents of Cuenca and santa isabel, the prevalence of food allergy and its association with reported risk factors determined by self-report and skin prick test. METHODS: A cross-sectional study was developed in 1508 adolescents (n = 1008) of Cuenca and santa isabel (n = 500), between July 2013 and July 2014. to define food allergy and risk factors of food allergy self-reported and unsatisfied basic needs questionnaires were applied. Aeroallergen sensitization was determined by skin prick test with aeroallergens. Linear regression models were applied to determine the associations between food allergy and factors risks. RESULTS

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“…In Chile, our group and other researchers have recently estimated the prevalence of allergic diseases and asthma to be at 13% for AD [6], 5.5% for FA [6], 21% for AR [7], and 14% for asthma [8]. It is well known that children with early-onset, severe, persistent AD, and elevated levels of total and specific immunoglobulin E (IgE) antibodies, have an increased risk of developing AR and asthma later in life [9,10].…”

Section: Introductionmentioning

confidence: 99%

Early origins of allergy and asthma (ARIES): study protocol for a prospective prenatal birth cohort in Chile

et al. 2020

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Background: Growing evidence shows that atopic dermatitis (AD), food allergy (FA), allergic rhinitis, and asthma are largely determined during the first 1000 days (time elapsed from conception to the 2nd birthday). The ARIES birth cohort aims to determine prenatal and perinatal conditions, as well as genetic and epigenetic factors, that participate in the early setting of immune responses, and the role of these in the later determination of the risk of allergic diseases and asthma in the offspring. Methods: We have designed a birth cohort of 250 families with prenatal recruitment (~14 weeks). We will genotype relevant allergy/asthma-associated variants in trios and will perform immunophenotyping and evaluation of allergy biomarkers in cord blood. At 1 and 2 years of age we will assess if infants have developed allergic sensitization, AD, FA, as well as biomarkers of asthma including the asthma predictive index. We will also evaluate how maternal conditions modify immune programming through epigenetic modifications and will then depict newborn epigenetic cues of allergy/asthma risk. Next, we will assess composition/diversity of maternal gut, placenta, breastmilk and infant gut microbiome and their association with immunophenotype and biomarkers at birth, and clinical outcomes at age 1 and 2. Finally, we plan to assess how environmental exposures (perinatal outdoor and indoor pollution, allergens and endotoxin) affect the incidence of allergic sensitization, AD, FA, and risk of asthma.Discussion: The in-depth study of the ARIES birth cohort shall provide crucial information to understand the rising incidence of allergies and asthma in developing countries, and hopefully provide cues on how to prevent and treat these diseases.Trial registration: clinicaltrials.gov NCT04186949, retrospectively registered on December 5, 2019.

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Prevalence of parent-reported immediate hypersensitivity food allergy in Chilean school-aged children

Abstract: Up to 5.5% of school-aged Chilean children may suffer from FA, most frequently to walnut and peanut. It is critical to raise awareness in Chile regarding FA and recognition of anaphylaxis, and promote epinephrine autoinjectors in affected children.

Cited by 47 publications

References 21 publications

Caracterización clínica de pacientes chilenos con alergia alimentaria mediada por IgE

Caracterización clínica de pacientes chilenos con alergia alimentaria mediada por IgE

Estudio Transversal: Factores de Riesgo para Alergia Alimentaria en Adolescentes de Cuenca y Santa Isabel, Ecuador

Early origins of allergy and asthma (ARIES): study protocol for a prospective prenatal birth cohort in Chile

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