Prevalence of Parietal Cell Antibodies in a Large Cohort of Patients with Autoimmune Thyroiditis

Abstract

In conclusion, our study demonstrates a high, age-dependent prevalence of PCA in an unselected large population of patients with AIT.

Factors associated with parietal cell autoantibodies in the general population

“…Although other studies have been published about the prevalence of PCA, they included fewer individuals, groups of patients with different autoimmune diseases and healthy individuals [33][34][35].…”

Are patients with autoimmune thyroid disease and autoimmune gastritis at risk of gastric neuroendocrine neoplasms type 1?

“…Autoimmune thyroid disease (AITD) is encountered in 10–15% of the general population and is often associated with various other autoimmune diseases, such as autoimmune gastritis (AG) . In patients with AITD, the prevalence of antiparietal cell antibodies (APCA) has been reported to range from 12–40%, as opposed to 2·5–9% in the general population .…”

Hashimoto’s Thyroiditis and Autoimmune Gastritis

“…This is in keeping with the evidence that chronic autoimmune thyroiditis represents the more prevalent autoimmune disorder worldwide making the frequency of thyrogastric syndrome quite high (4). This notion is supported by the high percentage (12–40%) of positivity of PCA in adult patients with HT (9) which, in turn, is present in approximately 40% of patients with atrophic gastritis (10). Besides the fact that the thyroid and the stomach share some embryological and biochemical features (11), some intriguing similarities have been observed even in the putative pathogenic mechanisms, which characterize the thyrogastric syndrome (12).…”