Objective: This study aims to determine the prevalence and pattern of partial edentulism among dental patients attending the Najran Specialist Dental Center, Najran, Saudi Arabia. Materials and Methods: Data was collected from 640 subjects who reported to the Najran Specialist Dental Center, Najran, Saudi Arabia and were prescribed with removable dental prostheses (RDP). Intraoral clinical and radiographic examinations were performed. The subjects were categorized into four age groups: 30-40, 41-50, 51-60, and > 60 years. Levels of educational and monthly income status were recorded, encoded into a SPSS program, and analyzed using Chi-square test. Results: Among all the dental patterns, Kennedy class II obtained the highest number of occurrence in the maxillary arch, whereas class I obtained the highest number of occurrence in the mandibular arch in both genders and all age groups. Kennedy class II obtained the highest number of occurrence, followed by class III in both arches in the monthly income groups. Class IV obtained the lowest number of occurrence in all age, gender, educational level, and monthly income groups in both arches. Conclusions: Among the selected subjects, Kennedy class I and II were the most prevalent patterns in both arches, all age groups, and both genders. Class IV was the least dominant pattern in all groups. The levels of educational and monthly income status played a role in the edentulism pattern of patients. Dental caries was the most common reason for tooth loss.