Prevalence of Pathogenic Genes cagA and vacA of Helicobacter pylori Isolated in Patients with Digestive disorders from 5 Azar Hospital in Gorgan city in 2017.

Heidari, Khatoon; Kaboosi, Hami; Jamali, Ailar; Ghaemi, Ezzat Allah; Ghadikolaii, Fatemeh Peyravii

doi:10.30699/ijmm.13.1.80

Cited by 4 publications

(5 citation statements)

References 24 publications

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“…80 Altogether, 120 H. pylori strains were isolated in another study conducted by Heidari et al The frequencies of cagA were 67.5%, 60%, and 45% in patients with GC, peptic ulcer, and without ulcer and GC, respectively, which confirms the results of the present study. 20 In summary, the role of H. pylori in GC development depends on pathogens and the host immune response. Therefore, the timely evaluation of the aforementioned factors would be helpful for the management and prevention of the further progression of GC.…”

Section: Discussionmentioning

confidence: 99%

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The Role of Cytokines and Pattern Recognition Receptors in Inflammation Caused by Helicobacter pylori Infection in Gastric Cancer

Ganjali

Fakheri

Bahari

et al. 2022

Int J Basic Sci Med

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One of the most common and most critical mortality causes in modern society is gastrointestinal (GI) cancer. Helicobacter pylori is one of the most potent risk factors of gastric cancer. This bacterium can suppress the immune system by various pathogenic factors and mechanisms, lead to chronic inflammatory responses, and play a critical role in the induction of cancer. The first part of this article begins with a description of H. pylori carcinogenicity and in the next part, the roles of innate immunity pattern recognition receptors (PRRs), Toll-like receptors (TLRs), cytokines, and inflammatory regulatory mechanisms in H. pylori infection are discussed. According to our current knowledge, screening and on-time diagnosis of the disease, timely treatment, and immediate eradication of H. pylori are the most critical ways to barricade gastric cancer progression. In the end, it is suggested that, considering the expensive costs of gastric cancer treatment, H. pylori diagnostic screening tests be done at least annually in middle-aged and at-risk people.

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Section: Discussionmentioning

confidence: 99%

“…Activation of these transcription factors leads to the expression of several genes, including carcinogenic genes, genes encoding chemokines, and genes that activate the anti-apoptotic cycle. 20 2. The second group of H. pylori genes includes variable phase genes.…”

Section: Carcinogenicity Of Helicobacter Pylorimentioning

confidence: 99%

The Role of Cytokines and Pattern Recognition Receptors in Inflammation Caused by Helicobacter pylori Infection in Gastric Cancer

Ganjali

Fakheri

Bahari

et al. 2022

Int J Basic Sci Med

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“…Spindle tuber viroid playing an important role in cell messaging; induction of apoptosis, ability to destroy gastric epithelial cells and gastric mucosal ulceration, and disrupting the function of intracellular membrane proteins. [19,[26][27][28] Hop: Helicobacter pylori outer membrane proteins…”

Section: Vaca: Vacuolating Cytotoxin Amentioning

confidence: 99%

“…This cytotoxin is also a B and T cellmediated immunosuppressant inhibiting antigen supply and enhancing H. pylori colonization [28]. Generally, H. pylori is colonized in gastric mucosa, causing inflammation and immune reactions, and ultimately leading to mucosal destruction, including atrophy and intestinal metaplasia and dysplasia [19].…”

Section: Vaca Cytotoxinmentioning

confidence: 99%

The Role of Helicobacter Pylori Virulence Factors in Gastric Cancer

Ganjali¹,

fakheri²,

Bahari³

et al. 2022

Multidiscip Cancer Investig

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Introduction: Gastrointestinal (GI) cancers are considered among the most important causes of mortality and morbidity. Helicobacter pylori infection has been proven to be highly associated with the development of a variety of gastric diseases such as chronic gastritis, peptic ulcer disease (PUD), mucosa-associated lymphoid tissue (MALT), and gastric cancer (GC). To date, the exact role of the virulence factors in gastric diseases and other diseases remains elusive and controversial. Methods: The present study is a classic systematic review (expert opinion), in which articles published in English and Persian languages derived from Web of Science, Scopus, PubMed, and Iranian databases, including Magiran, IranMede, and scientific information database (SID) without any time limitation were explored using standardized keywords of H. pylori, virulence factors, gastric cancer, a combination of the above words, and other synonymous keywords. Finally, the information and obtained results were collected and interpreted. Results: In total, 14 of the 172 articles reviewed had inclusion criteria with the approval of the responsible author. According to the results, the development of chronic bacterial inflammation due to pathogenic mechanisms and factors, especially the role of cagA and vacA genes in gastric cancer, remains an important medical problem. Conclusions: Each of the H. pylori virulence factors can have a role in cancer development, and it appears that on-time H. pylori treatment is one of the best methods to prevent gastric cancer. Therefore, targeting Pathogenic factors of H. pylori to induce apoptosis and stimulate the immune system will be a promising, attractive, and helpful method for cancer prevention.

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“…With the completion of the Human Genome Project and high-throughput sequencing technology [45][46][47], a large amount of colorectal cancer genomic data has been published, which directly introduces colorectal cancer related research into the fast-track development of highspeed development. Studies have found that carcinogens that can cause gene mutations in normal cells can promote the growth of colorectal cancer cells and malignant proliferation.…”

Section: Introductionmentioning

confidence: 99%

Screening of Pathogenic Genes for Colorectal Cancer and Deep Learning in the Diagnosis of Colorectal Cancer

Zhang

Xing

2020

IEEE Access

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Based on complex networks and machine learning methods, this paper studies the mining of colorectal cancer treatment genes, and innovatively combines a variety of feature extraction and comparative analysis methods, from gene network features, gene attribute features, network and attribute integration The three aspects of characteristics comprehensively excavate the genetic characteristics, and demonstrate the feasibility of the study through comparative analysis from different perspectives. Constructing a colorectal cancer gene network, analyzing the changes in the network structure during the development of colorectal cancer, and mining the network characteristics of genes are the first issues to be studied in this paper. The analysis of the network structure compares the changes in the network structure of the driver genes in the Normal network and the Tumor network and the edge mechanism of the driver genes, and the distribution of the eigenvalues of the driver genes and non-driver genes in the Tumor network. During the development of colorectal cancer, the network structure of the gene has changed significantly, and the prediction results based on the network structure show better prediction results than the non-network structure. These findings are feasible for the research direction of this paper. The argument is carried out, and the relevant analysis results are also given in the article. However, the research method of the thesis is based on network research, so comparing structural features with non-structural features only shows that structural features have a good classification ability, and cannot directly explain that modeling using gene networks is better than not using gene networks. Finally, based on the random forest, the optimized classification is improved to reveal the important factors affecting the diagnosis of colorectal cancer, and then to identify the true potential colorectal cancer driver genes, providing guidance for the clinical research of colorectal cancer and driving gene mining. INDEX TERMS colorectal cancer; gene screening; diagnosis; deep learning.

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Prevalence of Pathogenic Genes cagA and vacA of Helicobacter pylori Isolated in Patients with Digestive disorders from 5 Azar Hospital in Gorgan city in 2017.

Cited by 4 publications

References 24 publications

The Role of Cytokines and Pattern Recognition Receptors in Inflammation Caused by Helicobacter pylori Infection in Gastric Cancer

The Role of Cytokines and Pattern Recognition Receptors in Inflammation Caused by Helicobacter pylori Infection in Gastric Cancer

The Role of Helicobacter Pylori Virulence Factors in Gastric Cancer

Screening of Pathogenic Genes for Colorectal Cancer and Deep Learning in the Diagnosis of Colorectal Cancer

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