Prevalence of pathological duodenogastric reflux and the relationship between duodenogastric and duodenogastrooesophageal reflux in chronic gastrooesophageal reflux disease

Brillantino, Antonio; Monaco, Luigi; Schettino, Maria Teresa; Torelli, Francesco; Izzo, Giuseppe; Cosenza, Angelo; Marano, Luigi; Martino, Natale Di

doi:10.1097/meg.0b013e32830aba6d

Cited by 9 publications

(10 citation statements)

References 35 publications

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“…In our paper, we noticed that duodenogastric reflux is found in 34% of patients with GERD versus 25% mentioned in Brillantino's paper [1].…”

Section: Discussioncontrasting

confidence: 47%

“…The duodenogastric reflux was described in about 25% cases of patients with GERD according to the paper of Brillantino A et al [1]. They described duodenogastric reflux associated with gastric ulcer, gallbladder lithiasis and esophagitis and they pointed that the duodenogastric reflux can damage the gastric and esophageal mucosa due to the fact that it contains biliary acids and pancreatic juice [7][8].…”

Section: Discussionmentioning

confidence: 99%

“…The antireflux mechanism include: the pressure of low esophageal sphincter, Hiss's angle and the abdominal part of esophagus. There are some date which describe also a duodenogastric reflux associated with gastric ulcer, esophagitis and gallbladder lithiasis [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Is Gastroesophageal Reflux Disease Influenced by Duodenogastric Reflux ?

Mocanu¹,

Diculescu²,

Nicolae³

et al. 2013

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BACKGROUND: It is well known that the gastroesophageal reflux is a frequent disease in medical practice. A lot of factors are involved in its pathogenesis. The aim of our study was to find out if the duodenogastric reflux is one of these factors. We also looked for the pathological conditions associated with duodenogastric reflux. MATERIAL AND METHODS: We studied a lot of 59 cases (30 females and 29 males) with ages between 39 and 54 years old suffering from gastroesophageal reflux disease (GERD). GERD, duodenogastric reflux were confirmed by upper gastrointestinal endoscopy. The abdominal ultrasound exam were used to evaluate the duodenal and gallbladder motility (ejection fraction, EF). The severity of GERD was appreciated using GERD Q-score. RESULTS: The women to men ratio was 30 to 29 and the mean age was 42 ±2 years. Cholesterolosis was found in 45.7% (n=27) from the patients. From these patients, 92.6% (n=25) had a ejection fraction (EF) above normal (hyperkinesia) and only two patients had normal gallbladder motility. From the patients with cholesterolosis, 20 (74%) had duodenogastric reflux. The other 32 patients without cholesterolosis had no duodenogastric reflux neither. We noted a strong statistical correlation between the cholesterolosis and duodenogastric reflux (P=1,115x10 -8 ). The duodenogastric reflux was found in 33.89% (n=20) from the patients and half of them (n=10) had associated esophagitis; we found a strong statistical correlation between duodenogastric reflux and esophagitis: P=1,543x10 -13 . All the patients had GERD Q-scores higher than 7 points; the mean score was 11.25±4.04 points (range 8-18). The mean Q-score value for the cases with duodenogastric reflux was 16.2±3.37; the cases without duodenogastric reflux (n=39) had a mean Q-score of 9.2±1.23 (P=3,138x10 -9 ). CONCLUSION: These results suggest that biliary disease can contribute to the duodenogastric reflux and the duodenogastric reflux aggravates gastroesophageal reflux.

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“…In our paper, we noticed that duodenogastric reflux is found in 34% of patients with GERD versus 25% mentioned in Brillantino's paper [1].…”

Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Is Gastroesophageal Reflux Disease Influenced by Duodenogastric Reflux ?

Mocanu¹,

Diculescu²,

Nicolae³

et al. 2013

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“…However, current evidence using the multichannel impedance with pH sensor suggests that weakly acidic events (nadir pH between 4 and 7) in the esophagus are associated with classic GERD symptoms, particularly in patients taking proton pump inhibitors (PPIs) [31, 32]. In addition, studies using bilirubin monitoring together with pH monitoring showed a synergism between acid and bile reflux components in determining esophageal mucosal damage [33, 34]. …”

Section: Pathophysiologymentioning

confidence: 99%

Gastroesophageal Reflux Disease: Medical or Surgical Treatment?

Liakakos

Karamanolis

Patapis

et al. 2009

Gastroenterology Research and Practice

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Background. Gastroesophageal reflux disease is a common condition with increasing prevalence worldwide. The disease encompasses a broad spectrum of clinical symptoms and disorders from simple heartburn without esophagitis to erosive esophagitis with severe complications, such as esophageal strictures and intestinal metaplasia. Diagnosis is based mainly on ambulatory esophageal pH testing and endoscopy. There has been a long-standing debate about the best treatment approach for this troublesome disease. Methods and Results. Medical treatment with PPIs has an excellent efficacy in reversing the symptoms of GERD, but they should be taken for life, and long-term side effects do exist. However, patients who desire a permanent cure and have severe complications or cannot tolerate long-term treatment with PPIs are candidates for surgical treatment. Laparoscopic antireflux surgery achieves a significant symptom control, increased patient satisfaction, and complete withdrawal of antireflux medications, in the majority of patients. Conclusion. Surgical treatment should be reserved mainly for young patients seeking permanent results. However, the choice of the treatment schedule should be individualized for every patient. It is up to the patient, the physician and the surgeon to decide the best treatment option for individual cases.

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“…В то же время взаимозависимость параметров внутрипищеводного и внутрижелудочного рН, а также моторики верхних отделов пищеварительного тракта натощак и после приема пищи изучена недостаточно. Одним из наименее изученных аспектов проблемы является связь проявлений ГЭРБ, ассоциированной с разными типами рефлюкса в пищевод, и функциональных секреторных и моторно-тонических расстройств пищевода, желудка и двенадцатиперстной кишки (ДПК) [8,9].…”

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Gastric and duodenal secretory and motor-evacuatory activity in patients with gastroesophageal reflux disease associated with different types of reflux

2016

Ter. arkh.

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Prevalence of pathological duodenogastric reflux and the relationship between duodenogastric and duodenogastrooesophageal reflux in chronic gastrooesophageal reflux disease

Cited by 9 publications

References 35 publications

Is Gastroesophageal Reflux Disease Influenced by Duodenogastric Reflux ?

Is Gastroesophageal Reflux Disease Influenced by Duodenogastric Reflux ?

Gastroesophageal Reflux Disease: Medical or Surgical Treatment?

Gastric and duodenal secretory and motor-evacuatory activity in patients with gastroesophageal reflux disease associated with different types of reflux

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