Prevalence of perinatal asphyxia in East and Central Africa: systematic review and meta-analysis

Workineh, Yinager; Semachew, Ayele; Ayalew, Emiru; Animaw, Worku; Tirfie, Mulat; Birhanu, Minychil

doi:10.1016/j.heliyon.2020.e03793

Cited by 47 publications

(54 citation statements)

References 57 publications

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“…Moreover, the higher prevalence in the far North could also be from the cultural practices; such as poor antenatal care, home delivery by unskilled attendants, inability of women to access hospital care without the husbands' permission etc. The study prevalence however is similar to the prevalence of 15.9% reported from a meta-analysis 15 and review undertaken in East and Central Africa. Most mothers who delivered babies with birth asphyxia in this study booked for ANC, majority of the mothers had no maternal illness during pregnancy and they delivered via spontaneous vaginal delivery.…”

Section: Discussionsupporting

confidence: 85%

Prevalence, Risk Factors and Outcome of Perinatal Asphyxia in Newborns at Benue State University Teaching Hospital Makurdi

Ochoga¹,

Ejeliogu

Michael³

et al. 2021

J Res Bas Clin Sci

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Perinatal asphyxia is a global neonatal problem, which significantly contributes to both neonatal morbidity and mortality. This study was therefore undertaken to determine the prevalence, risk factors and outcomes of perinatal asphyxia in Makurdi, Nigeria. A retrospective review of clinical data of all newborns managed at the Special Care Baby Unit of the Benue State University Teaching Hospital over a 5 year period (January 2015-December 2019) was carried out using the research clinical data form. Maternal information including biodata, obstetric history, perinatal events as well as neonates' presentation and outcomes were reviewed. All inborn neonates with Apgar scores <7 at 5 min or out-born neonates with no recorded Apgar scores but with history of poor cry/inability to cry at birth were classified as asphyxiated. Out of the 1142 neonates admitted during the study period, 127 neonates had perinatal asphyxia with prevalence of 11.1%. Eighty-four (66.1%) of the newborns were males, while 43(33.9%) were females with male to female ratio of 1.95:1 Majority of the newborns(89.1%) were managed and discharged without early neurologic complications; eight survived with early neurologic complications, eight were discharged against medical advice, while 7 newborns died, giving a case fatality rate of 5.5%.Risk factors significantly associated were Meconium-stained amniotic fluid(P=0.002) ,fetal presentation (P=0.030),and birth attendants (P=0.001). The burden of perinatal asphyxia still persists in our environment. Associated factors in this study were meconium-stained liquor and unskilled birth attendants. Hence pregnant women should be encouraged to attend antenatal care and should ensure skilled birth attendants attend delivery with capacity to conduct safe delivery and institute neonatal resuscitation when necessary.

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Section: Discussionsupporting

confidence: 85%

Prevalence, Risk Factors and Outcome of Perinatal Asphyxia in Newborns at Benue State University Teaching Hospital Makurdi

Ochoga¹,

Ejeliogu

Michael³

et al. 2021

J Res Bas Clin Sci

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“…This could be due the fact that asphyxia is caused by interruption of blood flow to the placenta that could further decrease blood flow to the vital organs like the kidney, brain, heart, and lung [ 51 , 52 ]. Another possible explanation for this is that the presence of high prevalence of perinatal asphyxia in East and Central Africa could be associated with increased incidence of NM in SSA [ 53 ]. Respiratory distress syndrome is also found to increase the hazard of NM of neonates treated in the NICUs of SSA.…”

Section: Discussionmentioning

confidence: 99%

Incidence Density Rate of Neonatal Mortality and Predictors in Sub-Saharan Africa: A Systematic Review and Meta-Analysis

Bitew

Alemu

Ayele

et al. 2020

International Journal of Pediatrics

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Background. Neonatal mortality in Sub-Saharan countries is remarkably high. Though there are inconsistent studies about the incidence density rate of neonatal mortalities (IDR) and predictors in Sub-Saharan Africa, they are inconclusive to policymakers and program planners. In this study, the IDR of neonatal mortalities and predictors was determined. Methods. Electronic databases (Web of Science, PubMed, EMBASE (Elsevier), Scopus, CINAHL (EBSCOhost), World Cat, Google Scholar, and Google) were explored. 20 out of 818 studies were included in this study. The IDRs and predictors of neonatal mortality were computed from studies conducted in survival analysis. Fixed and random effect models were used to compute pooled estimates. Subgroup and sensitivity analyses were performed. Results. Neonates were followed for a total of 1,095,611 neonate-days; 67142 neonate-days for neonates treated in neonatal intensive care units and 1,028,469 neonate-days for community-based studies. The IDRs of neonatal mortalities in neonatal intensive care units and in the community were 24.53 and 1.21 per 1000 person-days, respectively. The IDRs of early and late neonatal mortalities neonatal intensive care units were 22.51 and 5.09 per 1000 neonate-days, respectively. Likewise, the IDRs of early and late neonatal mortalities in the community were 0.85 and 0.31, respectively. Not initiating breastfeeding within one hour, multiple births, rural residence, maternal illness, low Apgar score, being preterm, sepsis, asphyxia, and respiratory distress syndrome were independent predictors of time to neonatal mortality in neonatal intensive care units and male gender, perceived small size, multiple births, and ANC were predictors of neonatal mortality in the community. Conclusion. The incidence density rate of neonatal mortality in Sub-Saharan Africa is significantly high. Multiple factors (neonatal and maternal) were found to be independent predictors. Strategies must be designed to address these predictors, and prospective studies could reveal other possible factors of neonatal mortalities.

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“…The prevalence of perinatal asphyxia is ~2 per 1000 live births in developed countries, but the number of those affected rises to 26 per 1000 in developing countries [ 1 , 2 , 3 , 4 , 5 , 6 ]. Perinatal asphyxia occurs worldwide in approximately 4 million newborns annually [ 7 ] and is responsible for 23% of all infant deaths and 8% of child deaths [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Alzheimer’s Disease Associated Presenilin 1 and 2 Genes Dysregulation in Neonatal Lymphocytes Following Perinatal Asphyxia

Tarkowska

Furmaga-Jabłońska

Bogucki

et al. 2021

IJMS

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Perinatal asphyxia is mainly a brain disease leading to the development of neurodegeneration, in which a number of peripheral lesions have been identified; however, little is known about the expression of key genes involved in amyloid production by peripheral cells, such as lymphocytes, during the development of hypoxic-ischemic encephalopathy. We analyzed the gene expression of the amyloid protein precursor, β-secretase, presenilin 1 and 2 and hypoxia-inducible factor 1-α by RT-PCR in the lymphocytes of post-asphyxia and control neonates. In all examined periods after asphyxia, decreased expression of the genes of the amyloid protein precursor, β-secretase and hypoxia-inducible factor 1-α was noted in lymphocytes. Conversely, expression of presenilin 1 and 2 genes decreased on days 1–7 and 8–14 but increased after survival for more than 15 days. We believe that the expression of presenilin genes in lymphocytes could be a potential biomarker to determine the severity of the post-asphyxia neurodegeneration or to identify the underlying factors for brain neurodegeneration and get information about the time they occurred. This appears to be the first worldwide data on the role of the presenilin 1 and 2 genes associated with Alzheimer’s disease in the dysregulation of neonatal lymphocytes after perinatal asphyxia.

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Prevalence of perinatal asphyxia in East and Central Africa: systematic review and meta-analysis

Cited by 47 publications

References 57 publications

Prevalence, Risk Factors and Outcome of Perinatal Asphyxia in Newborns at Benue State University Teaching Hospital Makurdi

Prevalence, Risk Factors and Outcome of Perinatal Asphyxia in Newborns at Benue State University Teaching Hospital Makurdi

Incidence Density Rate of Neonatal Mortality and Predictors in Sub-Saharan Africa: A Systematic Review and Meta-Analysis

Alzheimer’s Disease Associated Presenilin 1 and 2 Genes Dysregulation in Neonatal Lymphocytes Following Perinatal Asphyxia

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