Prevalence of periodontal pathogens in Brazilians with aggressive or chronic periodontitis

Cortelli, José Roberto; Cortelli, Sheila Cavalca; Jordan, S. F.; Haraszthy, Violet I.; Zambon, Joseph J.

doi:10.1111/j.1600-051x.2005.00777.x

Cited by 150 publications

(186 citation statements)

References 36 publications

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“…Additionally, such variations in the global distribution of periodontopathic bacteria could be important in the epidemiology and the treatment of periodontal diseases. In view of the limited data available on the Brazilian distribution of A. actinomycetemcomitans in chronic periodontitis subjects 5,7,22,23 and as this bacterium was also considered a true pathogen, we examined the occurrence of A. actinomycetemcomitans in Brazilian subjects with mild, moderate and severe chronic periodontitis.…”

Section: Discussionmentioning

confidence: 99%

“…2 Particularly, in the oral cavity A. actinomycetemcomitans has been strongly associated with aggressive periodontitis in several epidemiological studies, however, less investigated in chronic periodontitis patients. [3][4][5][6][7][8][9][10] This bacterium expresses several putative virulence factors which enable it to colonize the oral cavity, invade periodontal tissues and evade host defenses. 11 Additionally, different serotypes of A. actinomycetemcomitans have been shown to be associated with periodontal health and disease.…”

Section: Introductionmentioning

confidence: 99%

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Occurrence of Aggregatibacter actinomycetemcomitans in Brazilians with chronic periodontitis

et al. 2010

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Studies have suggested that A. actinomycetemcomitans is involved in the aetiology of aggressive periodontitis as well as in chronic periodontitis. This study was aimed at elucidating the occurrence of A. actinomycetemcomitans in a Brazilian population with chronic periodontitis. A total of 555 (mean age 33.04 ± 12.45) individuals, living in two large areas of the São Paulo State, namely "Baixada Santista" and "Vale do Paraíba", and diagnosed with mild [180 (mean age 29.59 ± 10.94)], moderate [241 (mean age 31.18 ± 11.45)] or severe [134 (mean age 33.04 ± 12.45)] chronic periodontitis were enrolled in this survey. Clinical exams including measurements of Probing Depth, Clinical Attachment Loss, Plaque and Gingival indices and subgingival microbiological assessments were performed at all population. The genomic DNA of A. actinomycetemcomitans was identified by Polymerase Chain Reaction from periodontal pocket samples. The occurrence of A. actinomycetemcomitans among chronic periodontitis subjects as well as its association with age and gender were statistically analysed using the Chi-square and Odds Ratio tests. The significance of differences was established at 5% (p < 0.05). A. actinomycetemcomitans was detected in 102 (18.37%) individuals: 29 (16.11%) mild; 42 (17.42%) moderate; and 31 (23.13%) severe chronic periodontitis with no statistical difference among groups. A higher occurrence of the searched bacterium was found both in the youngest group (p < 0.05) as well as in the female group (p < 0.05). This study elucidated that A. actinomycetemcomitans harbored subgingival pockets of our target group of chronic periodontitis subjects and that this bacterium seems to be inversely related to age, but related to the female gender.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Occurrence of Aggregatibacter actinomycetemcomitans in Brazilians with chronic periodontitis

et al. 2010

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“…Localized aggressive periodontitis is mainly associated with the bacteria Aggregatibacter actinomycetemcomitans (41,42) , while generalized aggressive periodontitis is strongly associated with specific bacteria such as Porphyromonas gingivalis, Tannerella forsythia (43,44) and Aggregatibacter actinomycetemcomitans, Gram-negative coccobacillus, capnophile, microaerophilic (45) . Microorganisms produce several virulence factors that could be involved in the destruction of periodontal tissues.…”

Section: Microbiologymentioning

confidence: 99%

Diagnóstico y tratamiento de la periodontitis agresiva

Benza-Bedoya

Pareja-Vásquez

2017

Odontoestomatología

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Aggressive periodontitis is a low-prevalence, multifactorial disease, of rapid progression and with no systemic compromise. It presents immunological alterations, a strong genetic influence, familial aggregation and early onset. It can be localized or generalized. It is not clear whether it is an independent periodontal disease, or if it is the phenotypic expression of chronic periodontitis in susceptible patients. Its diagnostic protocol includes a dental medical history, a clinical periodontal examination and a radiological examination. Treatment usually includes improving oral hygiene, dental scaling and root planing, as well as systemic and local antibiotic therapy. Surgical therapy will depend on each individual case. Maintenance therapy is essential to achieve better results. The aim of this paper is to review diagnostic and therapeutic protocols, and to propose a treatment flowchart based on the latest scientific evidence.

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“…The polymerase chain reaction (PCR) method has been applied as a technique for the detection of A. actinomycetemcomitans in subgingival biofilm samples and saliva (35,36,39). Several studies have shown that this methodology appears to have a great potential in the microbiological diagnoses of periodontal diseases and detection of periodontal pathogens directly in subgingival biofilm samples (6,7,14,33,38).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of leukotoxic genotypes of Actinobacillus actinomycetemcomitans in Brazilians with chronic periodontitis

Rosalem¹,

Andrade²,

Colombo³

2006

Braz. J. Microbiol.

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Actinobacillus actinomycetemcomitans is considered a major etiologic agent of aggressive periodontitis but this species has also been associated with other forms of periodontal disease. Further, highly leukotoxic strains are related to severity of disease. This investigation determined the prevalence of A. actinomycetemcomitans and the occurrence of the leukotoxin gene 530-bp deletion in Brazilian subjects with chronic periodontitis. Twenty periodontally healthy and 20 chronic periodontitis subjects were selected. Fullmouth clinical examination was carried out at 6 sites/tooth. Subgingival biofilm samples were collected from the 3 deepest sites and 3 healthy sites from periodontitis subjects, as well as from 3 sites of individuals with periodontal health. A. actinomycetemcomitans and the genetic deletion were determined by the polymerase chain reaction. Significant differences were sought by Mann-Whitney, Chi-square, and Wilcoxon sign tests. Periodontitis subjects presented a higher prevalence (75%) of A. actinomycetemcomitans than individuals with health (45%) (p = 0.053). A mean frequency of 57.5% of A. actinomycetemcomitans -positive sites was observed in the periodontitis group. Of those, 75% were diseased, whereas 40% were healthy sites (p = 0.0001). Healthy subjects showed a mean frequency of 35% of positive sites. In contrast, the genetic deletion was detected only in 4 diseased sites from 2 chronic periodontitis patients. A high prevalence of A. actinomycetemcomitans was observed in Brazilians with chronic periodontitis. However, the leukotoxin gene 530-bp deletion was rarely detected in the subgingival biofilm of these subjects.

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Prevalence of periodontal pathogens in Brazilians with aggressive or chronic periodontitis

Cited by 150 publications

References 36 publications

Occurrence of Aggregatibacter actinomycetemcomitans in Brazilians with chronic periodontitis

Occurrence of Aggregatibacter actinomycetemcomitans in Brazilians with chronic periodontitis

Diagnóstico y tratamiento de la periodontitis agresiva

Prevalence of leukotoxic genotypes of Actinobacillus actinomycetemcomitans in Brazilians with chronic periodontitis

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