Prevalence of Periodontitis in Patients Undergoing Hemodialysis: a Case Control Study

Altamimi, Ali Ghareeb; AlBakr, Saud Alnouri; Alanazi, Thamer Alaswad; Alshahrani, Faleh; Chalisserry, Elna Paul; Anil, Sukumaran

doi:10.5455/msm.2018.30.58-61

Cited by 16 publications

(14 citation statements)

References 30 publications

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“…Data on oral health parameters of CKD patients have been controversial. Some studies reported no difference in PI between patients with ESRD and controls (12-15), whereas others showed higher average plaque index in ESRD patients on dialysis (13,21,22). Several factors may have contributed to these differences, including inadequate adjusting for some confounding variables.…”

Section: Discussionmentioning

confidence: 99%

Is there association between chronic kidney disease and dental caries? A case-controlled study

Menezes¹,

Pereira²,

Ribeiro³

et al. 2019

Med Oral

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Background The purpose of this study was to assess the association between chronic kidney diseases (CKD) and dental caries. Material and Methods 107 patients with CKD and 107 with no systemic alteration were randomly included. DMFT (decayed, missing, and filled teeth), plaque index, colony-forming units (CFU) of Streptococcus mutans and salivary composition (IgA total, IgA anti- Streptococcus mutans, calcium and urea) were evaluated. McNemar and Wilcoxon tests were used to compare test and control groups. Spearman test was used to correlate time of hemodialysis and variables studied. Associations between variables were evaluated by logistic regression analysis. Results The number of filled teeth, the amount of IgA anti-Streptococcus mutans, salivary urea, education level, monthly income and the amount of CFU of Streptococcus mutans were statistically different between groups. There was a positive correlation between the duration of hemodialysis (Hd) and the amount of IgA anti-Streptococcus mutans, urea in saliva, and the number of CFU of Streptococcus mutans. In the adjusted model, a higher incidence of CFU mutans streptococci, elevated salivary urea, smaller number of filled teeth, lower DMFT, and less calcium salivary were associated with CKD. Conclusions Programs to prevent and treat oral problems and regular follow-up at the beginning of dialysis are necessary to increase patients’ awareness of their condition. Key words: Renal disease, chronic, dental caries, renal dialysis.

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Section: Discussionmentioning

confidence: 99%

Is there association between chronic kidney disease and dental caries? A case-controlled study

Menezes¹,

Pereira²,

Ribeiro³

et al. 2019

Med Oral

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“…Evidence supports ESRD could make periodontal microbial community different from that of those without ESRD [ 44 ]. The interplay between microbial agent and the adjacent periodontal tissues often increases gingival inflammation and releases biologically active substances [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Periodontal health related–inflammatory and metabolic profiles of patients with end-stage renal disease: potential strategy for predictive, preventive, and personalized medicine

Wang

et al. 2021

EPMA Journal

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Objectives To compare the periodontal health related–inflammatory and metabolic differences between patients with end-stage renal disease (ESRD) and healthy controls (HC), and to identify potential biomarkers in gingival crevicular fluid (GCF) and serum of ESRD patients for predictive, preventive, and personalized medicine (PPPM). Methods Patients with ESRD (ESRD group; n = 52) and healthy controls (HC group; n = 44) were recruited. Clinical periodontal parameters were recorded. The differential metabolites in the GCF and serum were identified by liquid chromatography/mass spectrometry (LC/MS). Inflammatory markers including interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and C-reactive protein (CRP) were also assessed. Results In the ESRD group, IL-8 and CRP were significantly higher in GCF, whereas IL-6 and CRP were significantly higher in serum, compared with HC group (all P < 0.05). In the case of GCF, taurine levels were positively correlated with IL-8 levels in both groups (all P < 0.05). In the case of serum, l-phenylalanine and p-hydroxyphenylacetic acid levels were positively correlated with CRP levels in both groups (all P < 0.05). Significant positive correlations were observed between metabolites (including pseudouridine, l-phenylalanine, and p-hydroxyphenylacetic acid) and IL-6 levels only in ESRD group. Conclusions IL-8 and CRP are potential inflammatory makers that reflect the periodontal health of ESRD individual, which may be considered the valuable predictive diagnostics in the agreement with PPPM philosophy. Besides, metabolites of taurine in GCF as well as l-phenylalanine and p-hydroxyphenylacetic acid in serum are possible biomarkers correlated with inflammatory markers. All these biomarkers may also be highly recommended as a novel predictive/diagnostic tool for the assessment of inflammatory status from the perspectives of PPPM in view of susceptible population and individual screening.

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“…Many investigators have suggested that correct diagnosis and appropriate treatment of periodontal disease are important not only to the improvement of oral infection and inflammation, but also to maintain systemic health in patients receiving dialysis, and that managing oral health can effectively prolong survival [15,16,17,23,41,61,70]. In fact, brushing the teeth twice daily led to a reduced chance of developing periodontal diseases than brushing once daily, and it was identified as an independent factor [36].…”

Section: Management Of Periodontal Diseasementioning

confidence: 99%

“…Even if such reports are excluded, many studies have reported that over half of HD patients exhibit periodontitis [11,12,13,14]. Furthermore, most periodontal parameters in HD patients were reported to be significantly higher than those in age-matched control subjects and healthy individuals [15,16,17]. Thus, many investigators have shown that periodontal disease is an important issue in patients with PD and HD.…”

Section: Introductionmentioning

confidence: 99%

Periodontal Disease in Patients Receiving Dialysis

Miyata

Obata

Mochizuki

et al. 2019

IJMS

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Chronic kidney disease (CKD) is characterized by kidney damage with proteinuria, hematuria, and progressive loss of kidney function. The final stage of CKD is known as end-stage renal disease, which usually indicates that approximately 90% of normal renal function is lost, and necessitates renal replacement therapy for survival. The most widespread renal replacement therapy is dialysis, which includes peritoneal dialysis (PD) and hemodialysis (HD). However, despite the development of novel medical instruments and agents, both dialysis procedures have complications and disadvantages, such as cardiovascular disease due to excessive blood fluid and infections caused by impaired immunity. Periodontal disease is chronic inflammation induced by various pathogens and its frequency and severity in patients undergoing dialysis are higher compared to those in healthy individuals. Therefore, several investigators have paid special attention to the impact of periodontal disease on inflammation-, nutrient-, and bone metabolism-related markers; the immune system; and complications in patients undergoing dialysis. Furthermore, the influence of diabetes on the prevalence and severity of manifestations of periodontal disease, and the properties of saliva in HD patients with periodontitis have been reported. Conversely, there are few reviews discussing periodontal disease in patients with dialysis. In this review, we discuss the available studies and review the pathological roles and clinical significance of periodontal disease in patients receiving PD or HD. In addition, this review underlines the importance of oral health and adequate periodontal treatment to maintain quality of life and prolong survival in these patients.

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Prevalence of Periodontitis in Patients Undergoing Hemodialysis: a Case Control Study

Cited by 16 publications

References 30 publications

Is there association between chronic kidney disease and dental caries? A case-controlled study

Is there association between chronic kidney disease and dental caries? A case-controlled study

Periodontal health related–inflammatory and metabolic profiles of patients with end-stage renal disease: potential strategy for predictive, preventive, and personalized medicine

Periodontal Disease in Patients Receiving Dialysis

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