Prevalence of periodontitis in people clinically diagnosed with diabetes mellitus: a meta-analysis of epidemiologic studies

Zheng, Mengwen; Wang, Cheng; Ali, Ali; Shih, Yi An; Xie, Qinqin; Guo, Chao

doi:10.1007/s00592-021-01738-2

Cited by 32 publications

(24 citation statements)

References 75 publications

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“…In summary, this systematic review shows with the higher quality of evidence to date that severity of periodontitis is greater in patients with diabetes than in non-diabetic populations. This is relevant for clinical practice and confirms that oral cavity assessment should form a routine part in the clinical evaluation of patients with DM [38].…”

Section: Dm Increases the Severity Of Pdsupporting

confidence: 70%

“…DM is the most prevalent systemic disease in which it has been shown, after extensive research, that it predisposes to the development of PD [34][35][36][37]. A recent meta-analysis [38] that collected information from 27 studies (3092 diabetic patients and 23,494 controls) has reported a prevalence of PD of 67.8% in patients with DM and 35.5% in controls (odds ratio [OR] = 1.85; 95%CI = 1.61-2.11), results that in an unappealable way give an idea of the magnitude of the problem. Furthermore, cohorts that include patients with DM1 and DM2 report a higher prevalence of PD in DM1 (78.8% compared to DM2 (70.5%); OR = 2.60 vs. OR = 1.71).…”

Section: Periodontitismentioning

confidence: 99%

“…The parameters most commonly used to measure the severity of PD are the probing depth or pocket depth, the bacterial plaque index, the level of clinical anchorage, which constitutes an important indicator of tissue damage, the number of missing teeth, and the rate of bleeding on probing. A systematic review and meta-analysis [38] has indicated that all these severity indicators are significantly more altered in DM compared to controls. Probing depth was significantly deeper in diabetics compared with controls (mean difference [MD] = 0.23 mm, 95% CI = 0.17-0.29, p < 0.001) [38]; plaque index was significantly elevated in the diabetic group (MD = 0.20 mm, 95% CI = 0.18-0.23, p < 0.001) [38]; clinical attachment level also reflected higher degree of damage to periodontal tissue in diabetics (MD = 0.39 mm; 95% CI = 0.28-0.50, p < 0.001) [38]; diabetics with periodontitis had on average less teeth than the non-diabetic group with periodontitis (MD = −2.14 teeth, 95% CI= −2.87 to −1.40, p < 0.001) [38]; bleeding on probing was found affecting more teeth in the diabetic group compared with the control group (MD = 7.90 teeth; 95% CI, 4.24-1.56, p < 0.001) [38].…”

Section: Dm Increases the Severity Of Pdmentioning

confidence: 99%

“…A systematic review and meta-analysis [38] has indicated that all these severity indicators are significantly more altered in DM compared to controls. Probing depth was significantly deeper in diabetics compared with controls (mean difference [MD] = 0.23 mm, 95% CI = 0.17-0.29, p < 0.001) [38]; plaque index was significantly elevated in the diabetic group (MD = 0.20 mm, 95% CI = 0.18-0.23, p < 0.001) [38]; clinical attachment level also reflected higher degree of damage to periodontal tissue in diabetics (MD = 0.39 mm; 95% CI = 0.28-0.50, p < 0.001) [38]; diabetics with periodontitis had on average less teeth than the non-diabetic group with periodontitis (MD = −2.14 teeth, 95% CI= −2.87 to −1.40, p < 0.001) [38]; bleeding on probing was found affecting more teeth in the diabetic group compared with the control group (MD = 7.90 teeth; 95% CI, 4.24-1.56, p < 0.001) [38]. In summary, this systematic review shows with the higher quality of evidence to date that severity of periodontitis is greater in patients with diabetes than in non-diabetic populations.…”

Section: Dm Increases the Severity Of Pdmentioning

confidence: 99%

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State of Evidence on Oral Health Problems in Diabetic Patients: A Critical Review of the Literature

González‐Moles

Ramos‐García

2021

JCM

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Diabetes mellitus (DM) is a global health problem, having recognized that in the next 20 years the number of diabetic patients in the world will increase to 642 million. DM exerts enormous repercussions on general health diabetic (especially derived from vascular, cardiac, renal, ocular, or neurological affectation). It entails in addition a high number of deaths directly related to the disease, as well as a high health care cost, estimated at $673 billion annually. Oral cavity is found among all the organs and systems affected in the course of DM. Important pathologies are developed with higher prevalence, such as periodontitis (PD), alterations in salivary flow, fungal infections, oral cancer, and oral potentially malignant disorders (OPMD). It has been proven that PD hinders the metabolic control of DM and that the presence of PD increases the possibility for developing diabetes. Despite the relevance of these oral pathologies, the knowledge of primary care physicians and diabetes specialists about the importance of oral health in diabetics, as well as the knowledge of dentists about the importance of DM for oral health of patients is scarce or non-existent. It is accepted that the correct management of diabetic patients requires interdisciplinary teams, including dentists. In this critical review, the existing knowledge and evidence-degree on the preventive, clinical, diagnosis, prognosis, and therapeutic aspects of oral diseases that occur with a significant frequency in the diabetic population are developed in extension.

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Section: Dm Increases the Severity Of Pdsupporting

confidence: 70%

Section: Periodontitismentioning

confidence: 99%

Section: Dm Increases the Severity Of Pdmentioning

confidence: 99%

Section: Dm Increases the Severity Of Pdmentioning

confidence: 99%

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State of Evidence on Oral Health Problems in Diabetic Patients: A Critical Review of the Literature

González‐Moles

Ramos‐García

2021

JCM

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“…Ultimately, chronic and overwhelming inflammation causes periodontitis, which could only be terminated by tooth loss or therapeutic interventions. Recent studies have suggested a correlation between periodontitis and other systemic diseases including obesity, diabetes, hypertension, cardiovascular diseases and Alzheimer's disease (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Th17 Cells in Periodontitis and Its Regulation by A20

et al. 2021

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Periodontitis is a prevalent chronic disease that results in loss of periodontal ligament and bone resorption. Triggered by pathogens and prolonged inflammation, periodontitis is modulated by the immune system, especially pro-inflammatory cells, such as T helper (Th) 17 cells. Originated from CD4+ Th cells, Th17 cells play a central role for they drive and regulate periodontal inflammation. Cytokines secreted by Th17 cells are also major players in the pathogenesis of periodontitis. Given the importance of Th17 cells, modulators of Th17 cells are of great clinical potential and worth of discussion. This review aims to provide an overview of the current understanding of the effect of Th17 cells on periodontitis, as well as a brief discussion of current and potential therapies targeting Th17 cells. Lastly, we highlight this article by summarizing the causal relationship between A20 (encoded by TNFAIP3), an anti-inflammatory molecule, and Th17 cell differentiation.

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Different doses of vitamin D supplementation to nonsurgical treatment for vitamin‐D‐insufficient patients with diabetic periodontitis and the effect on gingival BMP‐2 levels

Lei

et al. 2023

The Kaohsiung J of Med Scie

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Epidemiological data show people with diabetes mellitus (DM) have three‐fold increase in risk of periodontitis. A vitamin D insufficiency can affect the progression of DM and periodontitis. This study evaluated the effects of different‐dose vitamin D supplementation to nonsurgical periodontal therapy for vitamin‐D‐insufficient diabetic patients coexisting with periodontitis and changes of gingival bone morphogenetic protein‐2 (BMP‐2) levels. The study included 30 vitamin‐D‐insufficient patients receiving nonsurgical treatment followed by administration of 25,000 international units (IU) vitamin D3 per week (the low‐VD group) and 30 patients receiving 50,000 UI vitamin D per week (the high‐VD group). The decreases of probing pocket depth, clinical attachment loss, bleeding index, and periodontal plaque index values of patients after the six‐month supplementation of 50,000 UI vitamin D3 per week to nonsurgical treatment were more significant than those after the six‐month supplementation of 25,000 UI vitamin D3 per week to nonsurgical treatment. It was found that 50,000 IU per week vitamin D supplementation for 6 months could lead to a better glycemic control for vitamin‐D‐insufficient diabetic patients coexisting with periodontitis after nonsurgical periodontal therapy. Increased levels of serum 25(OH) vitamin D3 and gingival BMP‐2 were found in both low‐ and high‐dose VD groups, and the high‐dose VD group exhibited higher levels than the low‐dose VD group. Vitamin D supplementation in large doses for 6 months tended to improve the treatment of periodontitis and increase gingival BMP‐2 levels in diabetic patients coexisting with periodontitis who were vitamin D deficient.

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Prevalence of periodontitis in people clinically diagnosed with diabetes mellitus: a meta-analysis of epidemiologic studies

Cited by 32 publications

References 75 publications

State of Evidence on Oral Health Problems in Diabetic Patients: A Critical Review of the Literature

State of Evidence on Oral Health Problems in Diabetic Patients: A Critical Review of the Literature

Th17 Cells in Periodontitis and Its Regulation by A20

Different doses of vitamin D supplementation to nonsurgical treatment for vitamin‐D‐insufficient patients with diabetic periodontitis and the effect on gingival BMP‐2 levels

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