Prevalence of peripheral neuropathy and its associated demographic and health status characteristics, among people on antiretroviral therapy in Rwanda

Tumusiime, David; Venter, François; Musenge, Eustasius; Stewart, Aimée

doi:10.1186/1471-2458-14-1306

Cited by 19 publications

(35 citation statements)

References 30 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unlike studies that found height as an independent risk factor in HIV-PN, several other studies reported no association. For instance, two Rwandese studies found no association between height and PN [ 39 , 40 ]. Studies where gender was not controlled have produced controversial findings too.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalent neuropathy in a cohort of HIV-infected Kenyan sex workers using antiretroviral drugs

Ndakala¹,

Oyugi²,

Oluka³

et al. 2016

Pan Afr Med J

View full text Add to dashboard Cite

IntroductionSeveral risk factors including stavudine and age have been strongly associated with polyneuropathy. However, conflicting data exist on height as an independent risk factor in polyneuropathy. The objective of this study is to exclude height as an independent polyneuropathy risk factor in a cohort of human immunodeficiency virus (HIV)-infected Kenyan sex workers.MethodsThis was an analysis of prospectively collected data of treatment-naive subjects initiating either stavudine or tenofovir diphosphate fumarate or zidovudine-based antiretroviral therapy (ART) regimens from January 2008 to August 2012. Polyneuropathy was characterised as burning sensation, numbness, or dysesthesia. The study used arithmetic means of weight (kg) and height (cm) measured in duplicates using calibrated scales.ResultsAfter exclusion of duplicate data sets and un-confirmed cases of polyneuropathy, the study identified 212 patients without polyneuropathy, 14 pre-ART and 94 post-ART related polyneuropathy cases. Polyneuropathy cases were older but did not differ in demographic, clinical and laboratory parameters at baseline. There was a significant difference in first-line ART regimens with more patients on tenofovir disoproxil fumarate in the post-ART group (p=0.017).ConclusionPolyneuropathy is a common disorder among HIV-infected Kenyan sex workers. These data cannot support the postulated increased risk by height after matching for gender and ART duration. Though stavudine is associated with polyneuropathy, in this study many patients previously not exposed to stavudine developed polyneuropathy. This suggests the involvement of unknown risk factors such as genetic and metabolite differences in the development of polyneuropathy.

show abstract

Section: Discussionmentioning

confidence: 99%

“…However, this study did not find a similar association. Other studies that reported no association between d4T and PN include studies by Luma et al, [ 31 ] and Tumusiime et al, [ 39 ]. Lack of association was suggested to be due to the limited proportion of d4T users or other risk factors other than d4T [ 35 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalent neuropathy in a cohort of HIV-infected Kenyan sex workers using antiretroviral drugs

Ndakala¹,

Oyugi²,

Oluka³

et al. 2016

Pan Afr Med J

View full text Add to dashboard Cite

show abstract

“…These differences may include variations in comorbidities, age, and ethnicity, which could affect individuals’ responses to self-management strategies to alleviate PN symptoms [ 75 – 79 ]. For example, HIV patients with neuropathy are more likely to be male and younger than those with diabetic neuropathy or CIPN, as diabetes and cancer incidence increase with age, and PN disproportionately affects women [ 77 , 79 , 80 ].…”

Section: Resultsmentioning

confidence: 99%

Systematic review of the effectiveness of self-initiated interventions to decrease pain and sensory disturbances associated with peripheral neuropathy

et al. 2020

View full text Add to dashboard Cite

Purpose A small number of studies report that patients with peripheral neuropathy (PN) who engage in activities that promote a sense of personal well-being and provide physical, emotional, or spiritual comfort have a better quality of life and higher levels of adjustment to the changes generated by their illness and accompanying symptoms. This systematic review sought to evaluate the effectiveness of self-management activities that patients with PN initiate themselves to relieve PN symptoms and improve quality of life. Methods Search terms were limited to include self-management activities initiated by patients (i.e., activities with no or minimal involvement from clinicians) that aim to provide relief of PN symptoms. Outcomes included in searches were pain, numbness, and tingling, associated with PN and quality of life. Results The database searches identified 2979 records, of which 1620 were duplicates. A total of 1322 papers were excluded on the basis of screening the abstract. An additional 21 full text articles were excluded because they did not meet the eligibility criteria. A total of 16 papers were included in the review. Conclusion This review identified that a number of self-management strategies that were initiated by patients, including heat, exercise, meditation, and transcutaneous electrical nerve stimulation (TENS) therapy, may reduce self-reported PN symptoms. As the available studies were of low quality, these strategies warrant further investigation with more homogeneous samples, using more rigorously designed trials and larger samples. Implications for Cancer Survivors Patients experiencing PN may find a range of self-initiated strategies beneficial in reducing PN symptoms and improving quality of life. However, because of the low quality of the available studies, clinicians need to monitor patients' responses to determine the effectiveness of these interventions as adjuncts to clinician-initiated interventions.

show abstract

“…Several African studies have investigated the incidence of HIV‐SN and factors associated with its development . However, none of these studies assessed the incidence of SN in a cohort where all individuals were exposed only to TDF‐based cART.…”

Section: Introductionmentioning

confidence: 99%

“…Several African studies have investigated the incidence of HIV-SN and factors associated with its development. [13][14][15][16][17][18][19][20] However, none of these studies assessed the incidence of SN in a cohort where all individuals were exposed only to TDF-based cART. Instead, these studies included individuals who had been exposed to several ART regimens (including stavudine) or who were on cART regimens that did not include TDF (globally, the most common cART initiation regimen).…”

mentioning

confidence: 99%

Clinical diagnosis of sensory neuropathy in HIV patients treated with tenofovir: A 6‐month follow‐up study

Pillay

Wadley

Cherry

et al. 2019

J Peripheral Nervous Sys

View full text Add to dashboard Cite

Background Sensory neuropathy (SN) is a common and often painful neurological condition associated with HIV‐infection and its treatment. However, data on the incidence of SN in neuropathy‐free individuals initiating combination antiretroviral therapies (cART) that do not contain the neurotoxic agent stavudine are lacking. Aims We investigated the 6‐month incidence of SN in ART naïve individuals initiating tenofovir (TDF)‐based cART, and the clinical factors associated with the development of SN. Methods 120 neuropathy‐free and ART naïve individuals initiating cART at a single center in Johannesburg, South Africa were enrolled. Participants were screened for SN using clinical signs and symptoms at study enrolment and approximately every 2‐months for a period of ~6‐months. Diagnostic criteria for symptomatic SN was defined by the presence of at least one symptom (pain/burning, numbness, paraesthesias) and at least two clinical signs (reduced vibration sense, absent ankle reflexes or pin‐prick hypoaesthesia). Diagnostic criteria for asymptomatic SN required at least two clinical signs only (as above). Results A total of 88% of the cohort completed three visits within the 6‐month period. The 6‐month cumulative incidence of neuropathy was 140 cases per 1000 patients (95% CI: 80‐210) at an incidence rate of 0.37 (95% CI: 0.2‐0.5) per person year. Height and active tuberculosis (TB) disease were independently associated with the risk of developing SN (P < .05). Interpretation We found that within the first 6 months of starting cART, incident SN persists in the post‐stavudine era, with 11 (9%) of individuals developing asymptomatic SN, and 9 (8%) developing symptomatic SN.

show abstract

Prevalence of peripheral neuropathy and its associated demographic and health status characteristics, among people on antiretroviral therapy in Rwanda

Cited by 19 publications

References 30 publications

Prevalent neuropathy in a cohort of HIV-infected Kenyan sex workers using antiretroviral drugs

Prevalent neuropathy in a cohort of HIV-infected Kenyan sex workers using antiretroviral drugs

Systematic review of the effectiveness of self-initiated interventions to decrease pain and sensory disturbances associated with peripheral neuropathy

Clinical diagnosis of sensory neuropathy in HIV patients treated with tenofovir: A 6‐month follow‐up study

Contact Info

Product

Resources

About