Prevalence of Phenotypes and Genes of ABO and Rhesus (Rh) Blood Groups in Faisalabad, Pakistan

Hameed, Amjad; Hussain, Wajahat; Ahmed, Janbaz; Fazli-Rabbi,; Qureshi, Javed Anver

doi:10.3923/pjbs.2002.722.724

Cited by 15 publications

(5 citation statements)

References 4 publications

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“…This is consistent with prior findi ngs (Jeremiah, 2006;Lova et al (2007); Abdulazeez et al (2008) victims. This is consistent with the findings of Hameed et al (2002) and Mohammed et al (2004), who found that blood type AB had the lowest incidence in this research. This is consistent with prior research by Abdulazeez et al (2008), Bakare et al (2004), Erabor et al (2010), Jeremiah (2006), and Lova et al (2007.…”

Section: Table 3 Frequency Of Some Haemoglobin Genotype Withsupporting

confidence: 94%

Examining the association between malaria infection and the occurrence of ABO/Rhesus and hemoglobin variants in patients at a tertiary hospital in Port Harcourt, Nigeria

Akwuebu¹,

Mbeera²,

Aaron³

et al. 2023

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The spread of the ABO-Rh blood group and the haemoglobin genotype differs widely between racial and ethnic groupings. Patterns could fluctuate over time within the same community in various regions of the globe, which might indicate that a specific blood type gave resistance to an infectious illness. Therefore, it is crucial to have accurate and current information on how these blood types are distributed across human demographics. A total of 451 individuals were chosen at random, ranging in age from 1 to 15 years. The sample size was selected utilising Cochran sample size calculation as well as a rate of plasmodium in youngsters in Port Harcourt of 60.6%. Using a normal phlebotomy method, 2 ml of venous blood was extracted with little immobility within sterile circumstances from the dorsum of the hand or ante-cubital vein, as the occasion may indeed be. Employing thick and thin Giemsa-stained blood smears, malaria density was evaluated microscopically. The genotype of haemoglobin was determined using cellulose acetate membrane electrophoresis in Tris-EDTA borate buffer (PH 8.9). Atlas Medical ABO reagent was used to identify ABO blood type qualitatively. Data management and statistical analyses were carried out using the Statistical Analyses System SAS 9.4 (SAS Institute, Cary, North Carolina, USA), with p values less than.05 deemed statistically significant. Four hundred fifty-one (451) people took part in this study. The amount of research participants (394) tested rhesus positive (87.4%). Amongst ABO variations, blood type B+ 8 (32%), A+ 7 (28%), and O+ 6 (24%), were shown to be higher common with complex plasmodium. Blood type O+ 198 (46.48) was by far the most common of simple ABO/Rhesus + blood groups, followed by B+ 97(22.77%) and A+ 72 (22.77%). (16.90). Similarly, among ABO/Rhesus negative blood groups with uncomplicated falciparum malaria, blood group O- predominated with 41 (9.62%). A+, A-, B+, B-, AB+, O+, and O- blood types of class for uncomplicated plasmodium species load revealed a mean of 18114.03/l, 52760.10/l, 20021.47/l, 3428.33/l, 11084.33/l, 12460.34/l, and 4445.59/l in the identical sequence, with O- exhibiting the least susceptibility to malaria. In addition, for uncomplicated malaria parasite density, the haemoglobin genotype status indicated a mean of 113073.44/l, 111435.65/l, and 107250.3/1l for AA, AS, and SS in the same order, with AA indicating the highest sensitivity to plasmodium. The prevalence of haemoglobin genotypes AA, AS, and SS in the study participants was 72.5%, 20.6%, and 6.9%, respectively. Men made up 54.5% (246/451), although females made up 45.5% (205/451). The haemoglobin genotype AA predominated, with men (178) outnumbering girls (149), followed by AS (56 vs 37) and SS (12 against 31), correspondingly. The most frequent ABO blood type was O (54.3%), second by B (24.6%), A (19.7%), and AB (1.3%). The bulk of Rh+ blood cells (87.4%) were found in the Rh bloodstream. The bulk of Rh bloodstream (87.4%) were Rh+, whereas 12.6% comprised Rh. O+ (45.2%), B+ (23.3%), A+ (17.5%), O- (9.1%), A- (2.2%), AB+ (1.3%), B- (1.3%), and AB (0%) were always the mixed ABO and Rh blood types. Men’s blood groups B+ (60), B- (4), AB+ (4), and O+ (112) were significantly higher than female blood groups B+ (45), B- (2), AB+ (2), and O+ (94), whereas female blood groups A- (7) and O- (23) were higher than male blood types A- (2) and O- (23) (16).

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Section: Table 3 Frequency Of Some Haemoglobin Genotype Withsupporting

confidence: 94%

Examining the association between malaria infection and the occurrence of ABO/Rhesus and hemoglobin variants in patients at a tertiary hospital in Port Harcourt, Nigeria

Akwuebu¹,

Mbeera²,

Aaron³

et al. 2023

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“…For example among the Caucasians and blacks in United States it was reported as 47.0% and 46.0% respectively (Seeley et al, 1998). However, in Nepal group A has been reported as the most prevalent (Pramanik and Pramanik, 2000) while in Pakistan a study showed the predominance of group B (Hameed et al, 2002).…”

Section: Discussionmentioning

confidence: 93%

Frequency Distribution of Hemoglobin Variants, ABO and Rhesus Blood Groups among Students of African Descent

Pennap

2011

BMRJ

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Background: Hemoglobin variants, ABO and Rhesus blood groups are known to vary from one population to another. This study therefore sought to study the frequency of these indices among a cohort of Nigerian University students of African descent. The result will serve as a platform for instituting genetic counseling services with a view to reducing hemoglobinopathies. Methods: Two hundred consenting students were recruited and screened for hemoglobin variants by standard alkaline cellulose acetate electrophoresis. ABO and Rhesus blood groups were determined by the hemagglutination technique. Results: Of the 200 students aged 18 -25 years that were screened, 123 (61.5%) were males and 77 (38.5%) were females. Those with blood group O were the most prevalent (45%) followed by groups A (25.5%), B (25%) and AB (3.5%). Only 2 genotypes HbAA (78.5%) and HbAS (21.5%) were reported in this study. Rhesus D antigen was positive for 94% and negative for 6% of the study population. Conclusion:The frequency of ABO and Rhesus blood groups appeared to be stable and consistent with reports from previous studies in Nigeria. Blood group O was the most prevalent. This also means there is a large pool of ''apparently'' universal blood donors in this population. There was only one genotype variant reported (HbAS). This could imply a decline in hemoglobinopathies among Africans. Therefore the culture of genetic counseling must be encouraged and sustained.

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“…14 The prevalence is different between that study and ours (41% vs. 36%). In contrast, in some other studies of populations in other countries, 3,[15][16][17][18] blood group B was most prevalent. According to Tomilin et al, 19 blood group A was the most prevalent group in the Russian Federation.…”

Section: Discussionmentioning

confidence: 61%

Distribution of blood groups in the Iranian general population

et al. 2016

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We report the first study of antigen and phenotype prevalence within various blood group systems in the Iranian general population. In this retrospective study, samples from 3475 individuals referred to the Immunohematology Reference Laboratory of the Iranian Blood Transfusion Organization, Tehran, Iran, for paternity testing from 1998 to 2008 were additionally tested for red blood cell (RBC) antigens in the Rh, Kell, Kidd, Duffy, MNS, Lutheran, P1PK, and Xg blood group systems. The antigen testing was performed by the tube method, and the phenotype prevalences were expressed as percentages. Of 3475 (1857 male and 1618 female) blood samples, 1268 samples were typed as group O (36.49%), 1115 as group A (32.09%), 823 as group B (23.68%), and 269 as group AB (7.74%). In our sample population, 3152 (90.71%) samples were D+ and 323 (9.29%) were D-. Analysis of Rh antigen typing results showed e (3359; 96.66%) to be most prevalent in the Iranian population, followed by D (3152; 90.71%), C (2677; 77.04%), c (2557; 73.58%), and E (1059; 30.47%). In the Kell blood group system, 3293 (94.76%) samples were typed as K-k+. For the Kidd and Duffy blood group systems, the following were the most common phenotypes: Jk(a+b+) (1703; 49%), Jk(a+b-) (1006; 28.95%), Fy(a+b+) (1495; 43.02%), and Fy(a+b-) (1005; 28.92%). In the MNS blood group system, the following were the most common phenotypes: M+N+ (1668; 48%), M+N-(1310; 37.70%), S+s+ (1564; 45%), and S-s+ (1392; 40.06%). In the Lutheran and P1PK blood group systems, Lu(a-b+) and P1+ phenotypes were observed in 3292 (94.73%) and 1966 (56.58%) samples, respectively. The Xg antigen was present in 1953 (56.20%) samples versus 1522 (43.80%) samples identified as Xg(a-). Knowledge of the prevalence of RBC antigen phenotypes in a population can be useful in databank creation for providing antigen-negative compatible blood to patients with multiple alloantibodies. Immunohematology 2016;32: 135-139.

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Prevalence of Phenotypes and Genes of ABO and Rhesus (Rh) Blood Groups in Faisalabad, Pakistan

Cited by 15 publications

References 4 publications

Examining the association between malaria infection and the occurrence of ABO/Rhesus and hemoglobin variants in patients at a tertiary hospital in Port Harcourt, Nigeria

Examining the association between malaria infection and the occurrence of ABO/Rhesus and hemoglobin variants in patients at a tertiary hospital in Port Harcourt, Nigeria

Frequency Distribution of Hemoglobin Variants, ABO and Rhesus Blood Groups among Students of African Descent

Distribution of blood groups in the Iranian general population

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