Prevalence of Polycystic Ovary Syndrome in Patients With Pediatric Type 2 Diabetes

Cioana, Milena; Deng, Jiawen; Nadarajah, Ajantha; Hou, Maggie; Qiu, Yuan; Chen, Sondra Song Jie; Rivas, Angelica; Banfield, Laura; Alfaraidi, Haifa; Alotaibi, Ahlam; Thabane, Lehana; Samaan, M Constantine

doi:10.1001/jamanetworkopen.2021.47454

Cited by 35 publications

(31 citation statements)

References 73 publications

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“…Institutional Review Board approval and informed consent were not obtained because the data were anonymous and publicly available. This study was drafted and reported based on the guidelines of a meta-analysis of observational studies in epidemiology (MOOSE) ( 27 , 28 ).…”

Section: Methodsmentioning

confidence: 99%

Prevalence of polycystic ovary syndrome in patients with type 2 diabetes: A systematic review and meta-analysis

Long

Feng²,

Wen³

et al. 2022

Front. Endocrinol.

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PurposeWith type 2 diabetes mellitus (T2DM) occurring at a younger age, a greater number of women with T2DM experience reproductive health problems. The prevalence of polycystic ovary syndrome (PCOS), a common reproductive disease associated with T2DM, remains unknown in women with T2DM. This systematic review and meta-analysis aimed to determine the prevalence of PCOS in women with T2DM.MethodsStata 15.1 was used to perform a meta-analysis on the prevalence of PCOS in patients with T2DM included in this study. Additionally, a narrative review of the effects of different diagnostic methods, obesity, state, and other factors on the prevalence of PCOS was conducted.ResultsMeta-analysis showed that the overall prevalence of PCOS in women with T2DM was approximately 21%. Subgroup analysis showed that the incidence of PCOS in female patients aged 25-45 years was higher than that in female patients aged < 25 years. The prevalence of PCOS in obese women was 14%, which was lower than that in normal weight women and normal weight or overweight or obese women. Women with T2DM in Oceania had the highest incidence of PCOS, followed by those in Europe and Asia; women with T2DM in North America had the lowest incidence. In terms of PCOS diagnostic standards, the prevalence of PCOS diagnosed by the National Institutes of Health was the lowest. The prevalence of PCOS diagnosed on the basis of clinical symptoms and biochemical characteristics was the highest, and the prevalence of PCOS diagnosed on the basis of medical records was 20%.ConclusionsPCOS is a common disease in female patients with T2DM. The prevalence of PCOS in women with T2DM at childbearing age was higher than that in adolescent females. Women with T2DM at childbearing age should pay attention to the screening and prevention of PCOS to avoid the hazards of PCOS to reproductive health.Systematic review registrationPROSPERO, identifier CRD42022318657.

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Section: Methodsmentioning

confidence: 99%

Prevalence of polycystic ovary syndrome in patients with type 2 diabetes: A systematic review and meta-analysis

Long

Feng²,

Wen³

et al. 2022

Front. Endocrinol.

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show abstract

“…On the other hand, the presence of insulin resistance should reinforce the screening of adolescents for type 2 diabetes as a comorbidity [ 118 ]. There is a high incidence of type 2 diabetes in adolescents with PCOS [ 6 , 119 ] and both diabetes and PCOS increase risk of other comorbidities such as depression during adolescence [ 120 ].…”

Section: Main Criteria To Diagnose Pcos During Adolescencementioning

confidence: 99%

“…Polycystic ovary syndrome (PCOS) is one of the most common endocrine conditions, affecting 8–13% [ 1 ] of women and 3.4–19.6% of adolescent girls, depending on the diagnostic criteria used and population studied [ 2 , 3 , 4 , 5 , 6 ]. The highest prevalence (19.6%) was reported in adolescents with Type 2 diabetes [ 6 ]. PCOS is also a familial condition with twin studies indicating that hereditability is approximately 70% [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Criteria for Diagnosis of Polycystic Ovary Syndrome during Adolescence: Literature Review

2022

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Polycystic ovary syndrome (PCOS) is one of the most common endocrine conditions in women. PCOS may be more challenging to diagnose during adolescence due to an overlap with the physiological events of puberty, which are part of the diagnostic criteria in adult women. This review focuses on the evidence available in relation to PCOS diagnostic criteria for adolescents. Adolescent PCOS should be diagnosed using two main criteria irregular -menstrual cycles (relative to number of years post-menarche) and hyperandrogenism (clinical and/or biochemical); after excluding other conditions that mimic PCOS. Accurate definitions of the two main criteria will decrease challenges/controversies with the diagnosis and provide timely diagnosis during adolescence to establish early management. Despite the attempts to create accurate diagnostic criteria and definitions, this review highlights the limited research in this area, especially in the follow up of adolescents presenting with one diagnostic feature that are called “at risk of PCOS”. Studies in adolescents continue to use the Rotterdam diagnostic criteria that uses pelvic ultrasound. This is inappropriate, because previous and emerging data that show many healthy adolescents have polycystic ovarian morphology in the early years post-menarche. In the future, anti-Müllerian hormone levels might help support PCOS diagnosis if adolescents meet two main criteria.

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“…Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that occurs in 1.14% to 11.04% of adolescent girls globally. [1][2][3] The diagnostic criteria for PCOS in adolescence include the combination of menstrual irregularities according to time since menarche and clinical or biochemical hyperandrogenism but only after excluding other causes. [4][5][6][7][8] Pelvic ultrasonography is not recommended for PCOS diagnosis in girls who are less than 8 years since menarche according to international evidence-based guidelines, because it is associated with over-diagnosis of PCOS.…”

Section: Introductionmentioning

confidence: 99%

The prevalence of insulin resistance in polycystic ovarian syndrome cases at a tertiary care hospital: a cross sectional study

Borse

Kurkal

Abhade³

2022

Int J Reprod Contracept Obstet Gynecol

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Background: Insulin resistance (IR) is defined clinically as the inability of a known quantity of exogenous or endogenous insulin to increase glucose uptake and utilization in an individual as much as it does in a normal population PCOS is a disease of heterogeneous disturbance of reproductive, endocrine and metabolic functions. The objective of the study was to study the prevalence of insulin resistance in polycystic ovarian syndrome cases.Methods: The present cross sectional study was carried out at Obstetrics and Gynecology department, MGM medical college, Kalamboli, Navi Mumbai for a period of 2 years from 2011 to 2013 on total of 50 women aged between 16-39 years, coming to OPD with complaints of menstrual irregularities, infertility or hirsutism. After initial assessment, pelvic ultrasonography was done in these women to confirm the diagnosis of polycystic ovaries.Results: Majority 26 (52%) cases were in age group of 16-25 years and, majority 19 (38%) cases were in overweight (25-29.99) group. There were 21 (42%) women with insulin resistance When chi square test was applied to assess the association between BMI and insulin resistance, it was found to be statistically significant. (p=0.01).Conclusions: The prevalence of abnormal glucose tolerance, dyslipidemia, insulin resistance and metabolic syndrome was observed to be high in PCOS. We conclude that physician should consider that early recognition to reduce the incidence and severity of associated potential sequelae.

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Prevalence of Polycystic Ovary Syndrome in Patients With Pediatric Type 2 Diabetes

Cited by 35 publications

References 73 publications

Prevalence of polycystic ovary syndrome in patients with type 2 diabetes: A systematic review and meta-analysis

Prevalence of polycystic ovary syndrome in patients with type 2 diabetes: A systematic review and meta-analysis

Criteria for Diagnosis of Polycystic Ovary Syndrome during Adolescence: Literature Review

The prevalence of insulin resistance in polycystic ovarian syndrome cases at a tertiary care hospital: a cross sectional study

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