Prevalence of polycystic ovary syndrome (PCOS) in first-degree relatives of patients with PCOS

Kahsar-Miller, Melissa; Nixon, Christa; Boots, Larry R.; Go, Rodney C.P.; Azziz, Ricardo

doi:10.1016/s0015-0282(00)01662-9

Cited by 351 publications

(204 citation statements)

References 36 publications

Supporting

Mentioning

174

Contrasting

Unclassified

Order By: Relevance

“…Fathers of PCOS women show metabolic alterations more frequently than mothers; it has been previously suggested that the inheritance of PCOS could be preferentially paternal, based on the rates of PCOS in mothers and sisters of PCOS patients [42,43]. At the moment, we have no explanation for this observation.…”

Section: Discussionmentioning

confidence: 70%

Prevalence of Type II diabetes mellitus and insulin resistance in parents of women with polycystic ovary syndrome

Sir-Petermann¹,

Ángel

Maliqueo

et al. 2002

Diabetologia

View full text Add to dashboard Cite

Aims/hypothesis. Insulin resistance with increased risk of Type II (non-insulin-dependent) diabetes is a common feature of polycystic ovary syndrome (PCOS). To investigate antecedents of metabolic disorders in family members of patients with PCOS, we evaluated glucose tolerance and insulin resistance in parents of patients with PCOS compared to parents of healthy women. Methods. A total of 200 parents of women with clinical and hormonal evidence of PCOS (PCOSp) and 120 parents of healthy normally cycling women (HWp) were studied. A 75-g OGGT was performed and subjects were classified according to the World Health Organization (WHO) criteria (1999). Serum glucose and insulin were measured before the glucose load and 30, 60 and 120 min after. C-peptide and sex hormone-binding globulin were also determined before the glucose load. Insulin resistance was assessed by HOMA model and ISI composite.Results. The prevalence of Type II diabetes was 1.89-(1.06-3.38)-fold higher in PCOSp compared to HWp. Insulin resistance, evaluated by HOMA IR and ISI composite was also significantly higher in the PCOSp group compared to the HWp group. After both study groups were distributed by sex, and adjusted by age and BMI, the metabolic parameters were still significantly different between PCOSp and HWp. Conclusions/interpretation. The data suggest that parents of PCOS women exhibit insulin resistance and Type II diabetes more frequently than those of healthy women, thus constituting a high-risk group but an ideal cohort to detect and prevent the development of Type II diabetes. [Diabetologia (2002) 45:959-964] Keywords Type II diabetes, polycystic ovary syndrome, insulin resistance, family study.

show abstract

Section: Discussionmentioning

confidence: 70%

Prevalence of Type II diabetes mellitus and insulin resistance in parents of women with polycystic ovary syndrome

Sir-Petermann¹,

Ángel

Maliqueo

et al. 2002

Diabetologia

View full text Add to dashboard Cite

show abstract

“…Statistics also identified approximately 5 million women in the Unites States living with PCOS with a cost on average of 4 billion US dollars annually for just the management of PCOS (4). The experience has shown to have a genetic trend as it was found present in first relatives since the ratio of PCOS in mothers and sisters of patients with PCOS were observed to be 24% and 32% respectively (21).…”

Section: Statistics On Polycystic Ovarian Syndrome and Aetiology Of Pmentioning

confidence: 92%

Polycystic Ovarian Syndrome Trend in a Nutshell

Mohammed¹,

Nayak²

2017

International Journal of Women’s Health and Reproduction Scienc

View full text Add to dashboard Cite

“…The genetic predisposition for PCOS has been evaluated, and a familiar clustering is indicated [42,43] with higher androgen levels, increased prevalence of insulin resistance [43] and more often CVD in first-degree relatives [44][45][46]. The genetic contribution for symptom development in individual subjects is difficult to ascertain although 35% of mothers and 40% of sisters of women with PCOS also display characteristics of the syndrome [42].…”

Section: Pathophysiology Of Pcosmentioning

confidence: 99%

Metabolic Aspects of Polycystic Ovary Syndrome

2015

Postgraduate Obstetrics & Gynecology

View full text Add to dashboard Cite

Prevalence of polycystic ovary syndrome (PCOS) in first-degree relatives of patients with PCOS

Cited by 351 publications

References 36 publications

Prevalence of Type II diabetes mellitus and insulin resistance in parents of women with polycystic ovary syndrome

Prevalence of Type II diabetes mellitus and insulin resistance in parents of women with polycystic ovary syndrome

Polycystic Ovarian Syndrome Trend in a Nutshell

Metabolic Aspects of Polycystic Ovary Syndrome

Contact Info

Product

Resources

About