Prevalence of Polypharmacy among Egyptian Patients with Type 2 Diabetes Mellitus

Metwally, Tayseer; Aly, Hebatalla M

doi:10.21608/scumj.2020.116531

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…A study conducted in China found the rate of polypharmacy to be 72.2% [11], 55.2% in Egypt [12], 56.5% in Brazil [13], 31.1% in Sudan [14], and 60% in Italy [15]. More prevalence was found in Saudi Arabia, where the rate was 77.9% [5].…”

Section: Discussionmentioning

confidence: 99%

“…Insulin alone was prescribed for all type 1 diabetic, and it was prescribed for 14 (9.33%) of patients. Although type 1 diabetics were only 21.6% in previous studies, insulin was added as an adjuvant for type 2 diabetics if blood sugar was not controlled solely by oral anti-diabetic agents [12,22]. The third choice of oral anti-diabetic agents was DPP-4 Inhibitors like Sitagliptin and Linagliptin, for 10 (6.67%) of patients, unlike other studies, 10.5%, 8.51%, 7.35%, and 6.2% [9,16,22,25].…”

Section: Discussionmentioning

confidence: 99%

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Assessment of Polypharmacy among Diabetic Patients in Tertiary Care Hospital of Nepal

Yadav¹,

Acharya²,

Chhetri³

et al. 2023

Janaki Med. Coll. J. Med. Sci.

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Background & Objective: Diabetes mellitus is a long-term metabolic condition that is accompanied by co-morbidities. Patients therefore use anti-diabetic medications in addition to other medications. Treatment with numerous drugs involves many hazards in addition to effectiveness. Therefore, diabetic people use multiple medications. The main aims of this study were to find out the prevalence of polypharmacy and the factors responsible for polypharmacy, and the consequences of polypharmacy. Material and Methods: A prospective observational study was conducted at the outpatient department of the Universal College of Medical Sciences and Teaching Hospital, Bhairahawa, Nepal from 12th February to 31st March 2021. A total of 150 patients who met the inclusion criteria and agreed to give written informed consent were enrolled in this study. A pre-validated questionnaire was used to assess polypharmacy among diabetic patients. The Statistical Package for Social Sciences (SPSS) software version 20 was used to enter and analyze data. Results: A total of 150 diabetic patients were included in this study. Among them, about 62.66% had polypharmacy. Age and duration of disease were highly significant with polypharmacy. Coexisting chronic conditions were highly associated with polypharmacy, like cardiovascular (AOR=5.552), musculoskeletal (AOR=5.050), mental (AOR=7.835), and digestive (AOR=3.778). The most common oral anti-diabetic agent was metformin. Conclusion: Polypharmacy was highly prevalent among diabetic patients. The rate of polypharmacy increases as the age and duration of disease increases. Polypharmacy has many consequences, like adverse drug events, increased costs, decreased compliance, and decreased quality of life.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Assessment of Polypharmacy among Diabetic Patients in Tertiary Care Hospital of Nepal

Yadav¹,

Acharya²,

Chhetri³

et al. 2023

Janaki Med. Coll. J. Med. Sci.

View full text Add to dashboard Cite

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“…Egypt ranks as the ninth country regarding the highest incidence of diabetes worldwide. The incidence of diabetes in Egypt was 7.5 million in 2013 and is expected to increase to 13.1 million by 2035 (3) .…”

Section: Introductionmentioning

confidence: 99%

The effect of Metformin on salivary glands of rats with streptozocin-induced diabetes

El Moshy,

Radwan

2023

Egyptian Dental Journal

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Background: Diabetes mellitus, a chronic metabolic condition with rising incidence rates, burdens public health. Xerostomia, induced by salivary gland dysfunction, is a common diabetes consequence that causes oral infections as well as speech and mastication problems. Metformin is an efficient antidiabetic drug, however, its effects on salivary gland function are unclear. This study aimed to investigate the effect of diabetes on the salivary gland and to assess the potential ability of metformin to counter the diabetes effect on the salivary gland.Methodology: Eighteen adult male albino rats were divided into three groups: control, streptozotocin, and metformin. In streptozotocin, and metformin groups diabetes was induced and only the metformin group received oral administration of metformin 100 mg/kg. After 28 days, all rats were euthanized, and the parotid glands were dissected. Hematoxylin & Eosin stain and quantitative real-time PCR analysis were performed to evaluate histological changes and gene expression, respectively. Results:The streptozotocin group showed significant histological and morphometric changes in the salivary gland compared to the control group. However, the metformin group showed significant improvement in the histological picture compared to the streptozotocin group. The gene expression of TNF-α and IL-6 was significantly elevated in the streptozotocin group, while metformin administration significantly reduced their expression. Conclusion:The study suggests that metformin has a potential protective effect on salivary gland function in diabetic rats. These results provide valuable insights into the potential therapeutic use of metformin in treating xerostomia in individuals with diabetes.

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“…Multiple drug therapy has become the norm for treating most chronic illnesses, including Diabetes Mellitus, and polypharmacy may yet be unavoidable 2 . Hypertension, dyslipidemia, depression, and coagulopathies are typical comorbidities of diabetes, and each of these conditions may need one or more medications for effective management 3 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

IJPSR

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Polypharmacy is defined as the "prescription, administration, or use of more medications than are clinically indicated. It can lead to drug-drug interactions and result in adverse drug events. Therefore, this study aimed to determine the prevalence of polypharmacy and factors that independently predict polypharmacy prescription. 200 Type 2 Diabetes Mellitus (T2DM) patients were enrolled and analyzed. The overall prevalence of polypharmacy was 51%, with the average number of drugs prescribed being 4.68 ± 3.18. The odds of polypharmacy prescription increased with the duration of T2DM, with comorbid conditions, and were higher in patients with uncontrolled glycaemic status. At the same time, the other factors, gender, smoking, and alcohol habits, did not reveal any significant association with polypharmacy prescription. Thus the most common predictors of polypharmacy prescription found were duration of T2DM, comorbid conditions, and glycaemic status of the patient. The findings of this study would be helpful in Government programs in developing, evaluating, and implementing interventions for supporting medicines optimization and deprescribing in India.

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Prevalence of Polypharmacy among Egyptian Patients with Type 2 Diabetes Mellitus

Cited by 5 publications

References 16 publications

Assessment of Polypharmacy among Diabetic Patients in Tertiary Care Hospital of Nepal

Assessment of Polypharmacy among Diabetic Patients in Tertiary Care Hospital of Nepal

The effect of Metformin on salivary glands of rats with streptozocin-induced diabetes

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