Prevalence of posterior vitreous detachment in glaucoma patients and controls

Schwab, Christoph; Glatz, Wilfried; Schmidt, Bernd; Lindner, Ewald; Oettl, Karl; Riedl, Regina; Wedrich, Andreas; Ivastinović, Domagoj; Velikay-Parel, Michaela; Mossboeck, Georg

doi:10.1111/aos.13339

Cited by 14 publications

(16 citation statements)

References 20 publications

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“…In contrast to the recent published findings of Schwab et al. () who reported glaucoma patients to experience PVD at younger age compared to healthy controls, our results indicate the opposite. However, there seem to be significant differences in the methodology of PVD stage grading as Schwab et al.…”

Section: Discussioncontrasting

confidence: 99%

“…Furthermore, a stage 2 PVD was never seen in our study subjects as there was always, although sometimes minimal, separation present of the posterior hyaloid and ILM nasal to the optic disc when there was a concomitant perimacular PVD. In contrast to the recent published findings of Schwab et al (2017) who reported glaucoma patients to experience PVD at younger age compared to healthy controls, our results indicate the opposite. However, there seem to be significant differences in the methodology of PVD stage grading as Schwab et al discriminated between 'initial PVD' which is to be regarded as a PVD stage 1 and 'advanced PVD' which could be PVD stage 2, 3 or 4.…”

Section: Discussioncontrasting

confidence: 99%

“…Although others have hypothesized that the oxidative stress in glaucomatous eyes could lead to early vitreous liquefaction and PVD, our findings suggest the opposite (Le Goff & Bishop ; Schwab et al. ). As reactive oxygen species do disrupt hyaluronic acid (Ueno ), this would have significant impact on the core vitreous, but the vitreoretinal interface consists of laminin, fibronectin and collagen and these molecules anchor the posterior vitreous cortex to the surface of the retina and optic disc (Bu et al.…”

Section: Discussioncontrasting

confidence: 78%

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The vitreopapillary interface in healthy and glaucoma: posterior vitreous detachment in the vitreopapillary interface study

Willekens

Pinto

Lemmens

et al. 2018

Acta Ophthalmologica

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Purpose To investigate the vitreopapillary interface (VPI) in health and glaucoma according to the different stages of posterior vitreous detachment (PVD) formation. Methods Prospective single centre study including healthy subjects and glaucoma patients. PVD staging was performed with spectral domain optical coherence tomography. Gender, age, lens status and refractive error were assessed in both groups. Glaucoma patients additionally had a comprehensive ophthalmological investigation including intraocular pressure measurement, visual field testing and confocal imaging of the optic nerve head. Results Data on 523 subjects (993 eyes) were included from the VPI study (clinicaltrials.gov NCT02290795) database (493 eyes of 258 healthy subjects and 500 eyes of 265 glaucoma patients). Healthy subjects were significantly younger than primary open angle glaucoma patients (59.7 ± 14.81 versus 70.0 ± 10.78 years, p < 0.001), but were otherwise matched for refractive error and gender. Significantly more glaucomatous eyes were pseudophakic (26.6% versus 5.1%). Including only phakic nonoperated eyes from subjects between 50 and 80 years old decreased the age difference between healthy and open angle glaucoma (64.1 ± 8.0 versus 65.9 ± 6.7 years, p = 0.051). Comparing these subgroups rendered similar average ages for PVD stages 0 and 4, in contrast to the significant older age for the glaucoma subgroup in stage 1 (64.1 ± 6.01 versus 61.4 ± 8.38 years, p < 0.001) and a trend towards significance in stage 3 (70.8 ± 69.8 versus 67.5 ± 5.92 years, p = 0.051). Conclusion The VPI study is a large clinical trial investigating the VPI in health and glaucoma. A subset of glaucoma patients seems to experience stages 1–3 of PVD formation at older age compared to healthy subjects.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 78%

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The vitreopapillary interface in healthy and glaucoma: posterior vitreous detachment in the vitreopapillary interface study

Willekens

Pinto

Lemmens

et al. 2018

Acta Ophthalmologica

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“…Thereby, aqueous humor outflow resistance and increased intraocular pressure (IOP) increase, facilitating the clinical onset of glaucoma and supporting the hypothesis that oxidative stress is an important factor in open-angle glaucoma [10,14]. Recently, the observation that glaucoma is linked to premature posterior vitreous detachment (PVD) has led to the hypothesis that ROS, which appear increased in glaucoma, might also lead to changes of the vitreous [15]. However, the impact of glaucomatous oxidative stress on the vitreous has not been investigated yet.…”

Section: Introductionmentioning

confidence: 93%

Vitreous albumin redox state in open-angle glaucoma patients and controls: a pilot study

et al. 2020

Self Cite

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Purpose Numerous studies suggest that reactive oxygen species play a crucial role in the development of glaucoma. Since glaucoma patients exhibit posterior vitreous detachment earlier than controls, it has been suggested that reactive oxygen species-increased in glaucoma-also affect the vitreous. In the present study we evaluated the influence of open-angle glaucoma oxidative stress on the redox state of vitreous albumin. Methods Albumin redox states of the vitreous and plasma were evaluated in 22 subjects-11 open-angle glaucoma patients and 11 controls-matched for age, gender, and vitreous state. According to the redox state of cysteine-34, albumin can be separated into: human mercaptalbumin (the thiol form), human nonmercap-talbumin1 (a reversible modification due to mild oxidation), and human nonmercaptalbumin2 (an irreversible modification due to severe oxidation). Results Albumin of both, the open-angle glaucoma group and the control group, was more oxidized in the vitreous compared to plasma. Furthermore, significantly higher human nonmercaptalbumin1 fractions were found in the vitreous of open-angle glaucoma patients compared to controls. No significant differences were found in the plasma albumin fractions between the groups. Conclusion Our results support the hypothesis that oxidative stress plays a crucial role in open-angle glaucoma and that reactive oxygen species in glaucomatous eyes may also affect the vitreous.

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“…Collagen opacities, which are common in glaucoma, 28 may cause shadow effect by blocking the return of the illumination light from the retina. 29 The shadow effect results in an OCT image and vessel density values which falsely imitate reduced or missing perfusion (Figure 5).…”

Section: Image Quality and Artifacts In Optical Coherence Tomography mentioning

confidence: 99%

Optical Coherence Tomography Angiography in Glaucoma

Holló

2018

tjo

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Optical coherence tomography angiography (OCTA) comprises different OCT-based technologies developed for non-invasive assessment and measurement of optic nerve head and retinal perfusion. Currently the most clinically established approach is based on the split spectrum amplitude decorrelation algorithm, which detects moving red blood cells and eliminates all other information. The two main clinical fields in which OCTA offers clinically useful information are investigation of the macular retina (e.g. in macular degeneration and diabetic macular disease) and glaucoma. For glaucoma, the optic nerve head and the peripapillary retinal perfusion in the retinal nerve fiber layer, and the superficial perifoveal macular vasculature are the areas of interest. This review provides a comprehensive summary of the most important current and potential future applications of OCTA in glaucoma, but it does not address the nonglaucomatous optic nerve head or peripapillary and macular diseases.

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Prevalence of posterior vitreous detachment in glaucoma patients and controls

Abstract: Our results suggest that the presence or absence of PVD might be a valuable hint for diagnosing glaucoma - however, further research is needed to determine whether PVD can be used to supplement current glaucoma screening guidelines.

Cited by 14 publications

References 20 publications

The vitreopapillary interface in healthy and glaucoma: posterior vitreous detachment in the vitreopapillary interface study

The vitreopapillary interface in healthy and glaucoma: posterior vitreous detachment in the vitreopapillary interface study

Vitreous albumin redox state in open-angle glaucoma patients and controls: a pilot study

Optical Coherence Tomography Angiography in Glaucoma

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