Prevalence of Postmenopausal Osteoporosis in Italy and Validation of Decision Rules for Referring Women for Bone Densitometry

Spertino, Elena; Martino, Francesca; Isaia, Giovanni Carlo

doi:10.1007/s00223-013-9699-5

Cited by 17 publications

(14 citation statements)

References 42 publications

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“…Controls were recruited from the general population starting from the database used for our previous study, fully described elsewhere [ 27 ]. Briefly, controls were enrolled from the general practitioner lists amongst non-diabetic women without diseases active on bone metabolism, matched for age and BMI to T2DM patients, as previously described.…”

Section: Methodsmentioning

confidence: 99%

Type 2 diabetes affects bone cells precursors and bone turnover

Sassi¹,

Buondonno²,

Luppi³

et al. 2018

BMC Endocr Disord

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BackgroundHere we study the effect of type 2 diabetes (T2DM) on bone cell precursors, turnover and cytokines involved in the control of bone cell formation and activity.MethodsWe enrolled in the study 21 T2DM women and 21 non diabetic controls matched for age and body mass index (BMI). In each subject we measured bone cell precursors, Receptor Activator of Nuclear Factor κB (RANKL), Osteoprotegerin (OPG), Sclerostin (SCL) and Dickoppf-1 (DKK-1) as cytokines involved in the control of osteoblast and osteoclast formation and activity, bone density (BMD) and quality trough trabecular bone score (TBS) and bone turnover. T2DM patients and controls were compared for the analyzed variables by one way ANOVA for Gaussian ones and by Mann-Whitney or Kruskal-Wallis test for non-Gaussian variables.ResultsRANKL was decreased and DKK-1 increased in T2DM. Accordingly, patients with T2DM have lower bone turnover compared to controls. BMD and TBS were not significantly different from healthy controls. Bone precursor cells were more immature in T2DM. However the number of osteoclast precursors was increased and that of osteoblasts decreased.ConclusionsPatients with T2DM have more immature bone cells precursors, with increased number of osteoclasts and decreased osteoblasts, confirming low bone turnover and reduced cytokines such as RANKL and DKK-1. BMD and TBS are not significantly altered in T2DM although, in contrast with other studies, this may be due to the match of patients and controls for BMI rather than age.

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Section: Methodsmentioning

confidence: 99%

Type 2 diabetes affects bone cells precursors and bone turnover

Sassi¹,

Buondonno²,

Luppi³

et al. 2018

BMC Endocr Disord

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“…Osteoporosis is a skeletal disease characterized by low bone mass, structural deterioration of bone tissue, and compromised bone strength predisposing to an increased risk of fracture. [ 1 , 2 ] It is one of the most common metabolic diseases and a leading cause of morbidity and mortality in the elderly. [ 3 ] Prior studies showed that several conditions, such as aging, sex, period of amenorrhea, parental history of fracture, [ 4 , 5 ] dietary calcium intake, vitamin D deficiency, low body mass index (BMI), [ 6 ] reduced physical activity, [ 7 ] and thyroid function [ 8 ] have been proposed as associated factors in bone mineral density changes in the elderly.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of osteoporosis and related lifestyle and metabolic factors of postmenopausal women and elderly men

Tian

Yang²,

Wei³

et al. 2017

Medicine

123

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The aim of this study was to investigate the osteoporosis prevalence and the risks of postmenopausal women and elderly men in Gansu province.This cross-sectional study involved 3359 postmenopausal women and 3205 elderly males who were randomly selected from 7 areas in Gansu province. Areal bone mineral density (BMD) (g/cm2) was measured at the distal one-third radius of the nonstressed forearm using dual-energy X-ray absorptiometry (DXA: Osteometer MediTech). Factors related to osteoporosis were analyzed.The prevalence of osteoporosis in the entire study population was 9.65% for postmenopausal women and 8.08% for elderly males by WHO criteria, while the rate of osteopenia were 27.09% for postmenopausal women and 26.68% for elderly males. Risk of osteoporosis was significantly associated with age, menopause age, duration of menopause, body mass index (BMI), educational level, and alcohol consumption in postmenopausal women. In elderly men, age, BMI, current smoking, alcohol consumption, physical activity, and sun exposure were associated with osteoporosis. The bone turnover markers osteocalcin (OC) and C-terminal cross-linked telopeptides of type I collagen (β-CTX) were inversely correlated with BMD in both genders; serum P and 25(OH)D found no significant correlation with BMD. Serum Ca showed a positive effect on BMD in elderly men only.The osteoporosis prevalence of postmenopausal women and the men aged over 60 years in Gansu province is presented. Risk of osteoporosis was significantly associated with age, menopause age, year since menopause, BMI, and educational level in postmenopausal women. In elderly men, age, BMI, and current smoking were associated with osteoporosis. This study also found that higher OC and β-CTX level were associated with lower BMD. Poor 25(OH)D, Ca, P status were not associated with an increased risk of low BMD.

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“…Osteoporosis is a skeletal disease characterized by low bone mass, structural deterioration of bone tissue, and increased susceptibility to bone fractures [1,2]. Osteoporosis is one of the most common metabolic bone disorders and a leading cause of morbidity and mortality in the elderly [3].…”

Section: Introductionmentioning

confidence: 99%

The impact of osteoporosis on health-related quality of life in elderly women

Park¹

2018

biomedicalresearch

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Objective of this study was to assess the impact of osteoporosis on health-related quality of life (HRQoL) in elderly Korean women. Sociodemographic characteristics, medical history of osteoporosis, and the EuroQol-5 dimension questionnaire scores for 1,000 female participants aged 60 years or older were obtained from the 2015 Korean National Health and Nutrition Examination Survey (KNHANES). Demographic variables, including age, educational level and income, were significantly associated with HRQoL. Furthermore, osteoporosis had a significant effect on HRQoL in elderly Korean women. In the osteoporosis group, the adjusted odds ratios for disability on the ED-5Q dimensions were 1.92 (95% confidence interval (CI)=1.44-2.58, p<0.001) for mobility, 1.90 (95% CI=1.45-2.51, p<0.001) for pain/ discomfort, and 1.89 (95% CI=1.36-2.61, p=0.001) for usual activities. These findings indicate that osteoporosis has a significant impact on HRQoL and suggest that the prevention and treatment of osteoporosis may significantly improve quality of life in elderly women.

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Prevalence of Postmenopausal Osteoporosis in Italy and Validation of Decision Rules for Referring Women for Bone Densitometry

Cited by 17 publications

References 42 publications

Type 2 diabetes affects bone cells precursors and bone turnover

Type 2 diabetes affects bone cells precursors and bone turnover

Prevalence of osteoporosis and related lifestyle and metabolic factors of postmenopausal women and elderly men

The impact of osteoporosis on health-related quality of life in elderly women

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