Prevalence of preterminal pulmonary thromboembolism among patients on maintenance hemodialysis treatment before and after introduction of recombinant erythropoietin

Wiesholzer, Martin; Kitzwögerer, Melitta; Harm, Ferdinand; Barbieri, Gabriele; Hauser, Anna; Pribasnig, Andreas; Bankl, Hans; Balcke, P

doi:10.1016/s0272-6386(99)70222-2

Cited by 36 publications

(19 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Autopsy series have suggested that VTE events are relatively common in patients with ESRD. 6,7 Furthermore, epidemiologic studies have reported an increased risk for VTE in dialysis 8 and in renal transplant patients. 9 To our knowledge, CKD has not been evaluated as a risk factor for VTE in the general population.…”

mentioning

confidence: 99%

Chronic Kidney Disease Increases Risk for Venous Thromboembolism

Wattanakit

Cushman

Stehman‐Breen

et al. 2008

Journal of the American Society of Nephrology

294

160

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is associated with increased risk for cardiovascular disease morbidity and mortality, but its association with incident venous thromboembolism (VTE) in non-dialysis-dependent patients has not been evaluated in a community-based population. With the use of data from the Longitudinal Investigation of Thromboembolism Etiology (LITE) study, 19,073 middle-aged and elderly adults were categorized on the basis of estimated GFR, and cystatin C (available in 4734 participants) was divided into quintiles. During a mean follow-up time of 11.8 yr, 413 participants developed VTE. Compared with participants with normal kidney function, relative risk for VTE was 1.28 (95% confidence interval [CI] 1.02 to 1.59) for those with mildly decreased kidney function and 2.09 (95% CI 1.47 to 2.96) for those with stage 3/4 CKD, when adjusted for age, gender, race, and center. After additional adjustment for cardiovascular disease risk factors, an increased risk for VTE was still observed in participants with stage 3/4 CKD, with a multivariable adjusted relative risk of 1.71 (95% CI 1.18 to 2.49). There was no significant association between cystatin C and VTE. In conclusion, middle-aged and elderly patients with CKD (stages 3 through 4) are at increased risk for incident VTE, suggesting that VTE prophylaxis may be particularly important in this population.

show abstract

mentioning

confidence: 99%

Chronic Kidney Disease Increases Risk for Venous Thromboembolism

Wattanakit

Cushman

Stehman‐Breen

et al. 2008

Journal of the American Society of Nephrology

294

160

View full text Add to dashboard Cite

show abstract

“…4 In an autopsy study of hemodialysis patients, the prevalence of pulmonary thromboembolism was 12.43%. 15 The authors noted none had pulmonary thromboembolism diagnosed prior to autopsy. The VTE rate hints at underuse of and/or a need for prophylaxis.…”

Section: Discussionmentioning

confidence: 95%

Thromboembolism Prophylaxis in End‐Stage Renal Disease

Hergenroeder

Levine

Miller

2008

Dialysis & Transplantation

View full text Add to dashboard Cite

OBJECTIVE: This study aimed to identify risk for venous thromboembolism (VTE) and prophylaxis patterns for endstage renal disease (ESRD) patients admitted through the emergency department (ED).METHODS: ESRD patients admitted through the ED in an urban teaching hospital were enrolled in this observational cohort. Admissions through the ED were reviewed as part of a VTE prophylaxis utilization analysis. Patients with moderate to high risk for VTE based on a modifi ed risk assessment model were considered in need of prophylaxis. Prophylaxis was defi ned as medical (heparin/low-molecular-weight heparin) or mechanical prophylaxis. Readmissions during the following year were monitored through an electronic database for thrombosis-related International Classifi cation of Diseases, Ninth Revision codes.RESULTS: Thirty patients met enrollment criteria. Twenty of the 30 patients (67%) were at moderate or higher risk for VTE and considered in need of VTE prophylaxis; 6 patients (30%) were actively prophylaxed. High risk was associated with a lower probability of appropriate prophylaxis (p Ͻ 0.04). Three patients (10%) had a clotting-related outcome.CONCLUSIONS: The 30% rate of VTE prophylaxis in the ESRD group is consistent with the general prophylaxis rate. Lower-risk patients appropriately received no treatment, whereas treatment was omitted in high-risk ESRD patients.

show abstract

“…6,7 Epidemiologic studies have reported an increased risk for VTE in patients receiving dialysis. 8 Both non-tunneled and tunneled hemodialysis catheters are associated with increased risk for venous thrombosis due to higher blood turbulence and endothelial dysfunction -two out of three aspects of Wirchow's triad.…”

Section: Discussionmentioning

confidence: 99%