Prevalence of Prodromal Parkinson’s Disease as Defined by MDS Research Criteria among Elderly Patients Undergoing Colonoscopy

Škorvánek, Matej; Ladomirjakova, Zuzana; Han, Vladimir; Leško, Norbert; Feketeová, Eva; Jarcusková, D; Repkova, Barbora; Spišák, P.; Urbancikova, Zuzana; Vargova, Adriana; Gombošová, Laura; Zakuciová, Mária; Veselíny, Eduard; Trebuna, Frantisek; Mechírová, Eva; Gdovinová, Zuzana

doi:10.3233/jpd-161036

Cited by 13 publications

(8 citation statements)

References 23 publications

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“…Overall, we collected data for the vast majority of markers: 13 of 17 (8 of 10 prodromal markers). Furthermore, according to MDS recommendations and recent studies, pPD probability may be calculated using available markers in each cohort, keeping in mind that it may be underestimated if the number of markers is limited. Yet, pPD probability in our study was quite similar to that found in other cohort of older adults …”

Section: Discussionmentioning

confidence: 99%

Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease

et al. 2018

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Background The International Parkinson and Movement Disorder Society recently introduced a methodology for probability score calculation for prodromal PD. Objectives To assess the probability of prodromal PD in an older population and investigate its possible association with Mediterranean diet adherence. Methods Data from a population‐based cohort study of older adults (HEllenic Longitudinal Investigation of Aging and Diet) in Greece were used. Probability of prodromal PD was calculated according to International Parkinson and Movement Disorder Society research criteria. A detailed food frequency questionnaire was used to evaluate dietary intake and calculate Mediterranean diet adherence score, ranging from 0 to 55, with higher scores indicating higher adherence. Results Median probability of prodromal PD was 1.9%, ranging from 0.2 to 96.7% in 1,731 PD‐free individuals aged ≥ 65 (41% male). Lower probability for prodromal PD (P < 0.001) in the higher Mediterranean diet adherence groups was noted, driven mostly by nonmotor markers of prodromal PD, depression, constipation, urinary dysfunction, and daytime somnolence. Each unit increase in Mediterranean diet score was associated with a 2% decreased probability for prodromal PD (P < 0.001). Compared to participants in the lowest quartile of Mediterranean diet adherence, those in the highest quartile were associated with a ∼21% lower probability for prodromal PD. Conclusions Adherence to the Mediterranean diet is associated with lower probability of prodromal PD in older people. Further studies are needed to elucidate the potential causality of this association, potential relation of the Mediterranean diet to delayed onset or lower incidence of PD, as well as the underlying neurobiological mechanisms. © 2018 International Parkinson and Movement Disorder Society

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Section: Discussionmentioning

confidence: 99%

Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease

et al. 2018

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“…Such scores on the UPDRS 2 years prior showed a very high specificity of 97% and sensitivity of 94% with overall area under curve (AUC) of 0.99 for conversion to parkinsonism ( 42 ),. These cutoffs, however, still need to be validated in more prospective trials, as up to 30% of elderly patients may score >6 points on the MDS-UPDRS part III without including the action tremor items ( 57 ).…”

Section: Diagnostic Accuracy Of Clinical Measures For Predicting Convmentioning

confidence: 99%

Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies

et al. 2018

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Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by repeated episodes of REM sleep-related vocalizations and/or complex motor behaviors. Definite diagnosis of RBD is based on history and polysomnography, both of which are less accessible due to the lack of trained specialists and high cost. While RBD may be associated with disorders like narcolepsy, focal brain lesions, and encephalitis, idiopathic RBD (iRBD) may convert to Parkinson’s disease (PD) and other synucleinopathies in more than 80% of patients and it is to date the most specific clinical prodromal marker of PD. Identification of individuals at high risk for development of PD is becoming one of the most important topics for current PD-related research as well as for future treatment trials targeting prodromal PD. Furthermore, concomitant clinical symptoms, such as subtle motor impairment, hyposmia, autonomic dysfunction, or cognitive difficulties, in subjects with iRBD may herald its phenoconversion to clinically manifest parkinsonism. The assessment of these motor and non-motor symptoms in iRBD may increase the sensitivity and specificity in identifying prodromal PD subjects. This review evaluates the diagnostic accuracy of individual rating scales and validated single items for screening of RBD and the role and accuracy of available clinical, electrophysiological, imaging, and tissue biomarkers in predicting the phenoconversion from iRBD to clinically manifest synucleinopathies.

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“…On the whole, we collected data for the vast majority of MDS markers: 13 of 17 (8 of 10 prodromal markers). As MDS and recent studies have suggested, pPD probability may be calculated using available markers in each cohort, keeping in mind that it may be underestimated if the number of markers is limited.…”

Section: Methodsmentioning

confidence: 99%

Motor function and the probability of prodromal Parkinson's disease in older adults

et al. 2019

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Background Identification and characterization of Parkinson's disease (PD) in its prodromal stage is crucial. Objective The objective of this study was to investigate the association between motor function and the probability of prodromal PD in a community‐dwelling older population. Methods We used data from a population‐based cohort of older adults (HELIAD study). Subjective motor function was evaluated with a 12‐item motor symptoms questionnaire and objective motor function indirectly with a physical activity questionnaire and two gait speed tests. The probability of prodromal PD was calculated according to the Movement Disorder Society research criteria for n = 1731 without PD. Regression multiadjusted models were used to investigate the associations between each motor measure and prodromal PD probability. Results For each unit increase in motor symptoms score and for each kcal/kg/day lower energy expenditure (corresponding to 20 minutes of light walking/day for a 75‐kg man) there was a 27% and 3% higher probability for prodromal PD, respectively (P < 0.001). Having at least one subjective motor symptom increased the odds of having possible/probable prodromal PD (n = 49; P < 0.05). Including subjective and indirect motor variables in the same model showed that both (symptoms and physical activity) contributed significantly to the model (P < 0.01). Excluding subthreshold parkinsonism from the calculation showed that gait speed less than 0.8 m/s was also associated with a higher prodromal PD probability score (P < 0.001). Conclusions Subjective motor symptoms as well as simple objective motor measures of physical activity or gait speed are associated with a higher probability of prodromal PD in older adults. These data may serve to enable the early identification of prodromal PD cohorts, particularly if they are confirmed in longitudinal studies. © 2019 International Parkinson and Movement Disorder Society

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Prevalence of Prodromal Parkinson’s Disease as Defined by MDS Research Criteria among Elderly Patients Undergoing Colonoscopy

Cited by 13 publications

References 23 publications

Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease

Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease

Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies

Motor function and the probability of prodromal Parkinson's disease in older adults

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