Prevalence of pulmonary hypertension in patients with chronic kidney disease on and without dialysis

Emara, Magdy M; Habeb, M.; Alnahal, Alsayed; Elshazly, Tarek A.; Alatawi, Faisal O; Masoud, Amer S.

doi:10.1016/j.ejcdt.2013.09.011

Cited by 9 publications

(6 citation statements)

References 27 publications

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“…This is comparable to Moniruzzaman et al(12) and Kiykim et al(30) who detected the prevalence to be 68.6% and 68.8% in order. This was also confirmed by Emara et al(31) and Patel et al(18,32). It was also in concordance with Issa et al(33) and Bozbas et al (34).…”

supporting

confidence: 85%

The Incidence and Severity of Pulmonary Hypertension among Patients with Chronic Kidney Disease

Maher¹,

Fayed²,

Ahmed³

et al. 2023

EJHS

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Purpose: Chronic kidney disease (CKD) is a major health problem and is closely linked with cardiovascular disease. Pulmonary hypertension (PH) is considered a common comorbidity in CKD patients. This study aimed at assessing the correlation between CKD and pulmonary hypertension. Methodology: This is a retrospective study that recruited 100 Egyptian patients with stage 3 and above Chronic Kidney Disease (CKD) (KDOQI guidelines). The study sample was composed of 100 patients with 60% overall prevalence of PH. Transthoracic echo Doppler study was performed to measure pulmonary artery systolic pressure based on tricuspid jet in the sample. Findings: There was significant association between PH and severity of renal disease. The hemodialysed group showed a higher prevalence of PH with a more severe PH compared to groups not on regular dialysis. The study had provided evidence that PH is a common comorbidity in CKD patients and is directly proportional with the stage and duration of CKD. Recommendations: Pulmonary hypertension should be regularly assessed using echocardiography in CKD patients specially those on regular dialysis.

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supporting

confidence: 85%

The Incidence and Severity of Pulmonary Hypertension among Patients with Chronic Kidney Disease

Maher¹,

Fayed²,

Ahmed³

et al. 2023

EJHS

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“…Emara et al . [34] ( p < 0.001) and Patel et al . [19] (P = 0.001) also found a similar association.…”

Section: Discussionmentioning

confidence: 97%

“…Significant association of hemoglobin, BUN, serum creatine, and serum Ca × P product was observed in various studies. [19222734] It is postulated that low hemoglobin levels can contribute to PH by aggravating hypoxia. [39] PH in patients having raised Ca × P product may be attributed to increased stiffness of pulmonary vasculature caused by vascular calcification.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary hypertension in various stages of chronic kidney disease in Indian patients

et al. 2019

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The prevalence of pulmonary hypertension (PH) in chronic kidney disease (CKD) in Indian patients has been evaluated in this study. In addition, association of PH with CKD etiology, its prevalence in various CKD stages, correlation between the severity of PH with CKD duration, various related biochemical parameters, and their relation to PH in CKD patients were analyzed. This cross-sectional and prospective study included 200 CKD patients. Detailed history and clinical examination were recorded. Hemoglobin, blood urea nitrogen (BUN), serum creatinine, albumin, and calcium-phosphorus product were recorded. Pulmonary function test was evaluated and two-dimensional echo was done 4 hours post dialysis. The prevalence of PH in CKD patients was 60.5%, with mean pulmonary artery systolic pressure (PASP) of 38.52 ± 7.32 mmHg. The mean age of those with PH was 47.85 ± 13.09 years. PH was more common in males ( p = 0.03). The prevalence of PH increased as CKD stage advanced ( p < 0.001). Diabetes and hypertension had a strong association with PH ( p < 0.001). The prevalence ( p = 0.003) and severity ( p = 0.011) of PH increased with increase in CKD duration. In patients on hemodialysis (HD), the prevalence ( p < 0.001) and severity ( p = 0.022) of PH was significant compared to those on conservative treatment. The prevalence ( p < 0.001) and severity ( p < 0.001) of PH significantly increased as duration of HD increased. The prevalence of PH was significantly higher in patients with arteriovenous fistula ( p = 0.002). Serum creatinine ( p = 0.02) and serum calcium-phosphorus product ( p < 0.001) were significantly higher in patients with PH. The prevalence of PH in CKD patients was 60.5%. There was a positive correlation between PH and duration of CKD, duration of HD, BUN, serum creatinine, and serum calcium-phosphorus product.

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“…Mehta et al [10] discovered that people with HD for a long time had a higher prevalence of PAH. Emara et al [31], Patel et al [19], and Havlucu et al [32] discovered a similar link. In one study, increasing the duration of dialysis from one to two years increased the prevalence of PAH from 38 to 58% [33].…”

Section: Discussionmentioning

confidence: 81%

Evaluation of Risk Factors for Development of Pulmonary Hypertension in Patients with End Stage Renal Disease Undergoing Hemodialysis

Hussein Fadhil ,,

Mahdi Hashim ,,

Sami Malik ,

et al. 2023

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Background: Pulmonary arterial hypertension (PAH) has recently been identified as a common complication in patients with end-stage renal disease (ESRD) who are undergoing hemodialysis (HD) or peritoneal dialysis (PD). The risk factors for the development of PAH in those patients are not well understood. Objective: To investigate the risk factors for the development of PAH in patients with ESRD on HD. Patients and Methods: This is a hospital-based cross-sectional study of 50 ESRD patients undergoing HD. The pulmonary artery systolic pressure (PASP) was measured using echocardiography. PASP ˃ 25 mmHg at rest was defined as PAH. As a result, patients were divided into two groups: those who had PAH and those who did not. Each patient's demographic, biochemical, and echographic findings were documented. Results: Out of 50 patients, 19 (38%) had PAH, while the remaining 31 (62%) had normal PASP. In multivariate analysis, HD duration > 3.4 years (OR= 2.13, 95%CI=1.45-31.38, p= 0.025), hypertension as a cause of ESRD (OR=6.12, 95%CI=1.4-26.77, p=0.031), hemoglobin (Hb) ≤ 10.0 g/dl (OR= 4.35, 95%CI=1.88-9.84, p= 0.018), and left ventricular ejection fraction (LVEF)≤ 55% (OR= 6.75, 95%CI=1.87-23.74, p=0.021) were independent factors associated with PAH. PASP had a significant positive correlation with the rate of fistula flow (r= 0.295, p= 0.038) and E/A ratio (r= 0.368, p= 0.008), but a significant negative correlation with LVEF (r= -0.345, p= 0.014). PASP had a positive significant correlation with each of rate of fistula flow (r= 0.295, p= 0.038) and E/A ratio (r= 0.368, p= 0.008), while it has a negative significant correlation with LVEF (r= -0.345, p= 0.014). Conclusion: Longer duration of HD, hypertensive nephropathy as a cause of ESRD, Hb≤ 10 g/dl, and LVEF ≤55% are among the demographic, biochemical, and clinical factors associated with the development of PAH in patients with ESRD under HD. The PASP has a positive correlation with fistula flow rate and E/A ratio and a negative correlation with LVEF.

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Prevalence of pulmonary hypertension in patients with chronic kidney disease on and without dialysis

Cited by 9 publications

References 27 publications

The Incidence and Severity of Pulmonary Hypertension among Patients with Chronic Kidney Disease

The Incidence and Severity of Pulmonary Hypertension among Patients with Chronic Kidney Disease

Pulmonary hypertension in various stages of chronic kidney disease in Indian patients

Evaluation of Risk Factors for Development of Pulmonary Hypertension in Patients with End Stage Renal Disease Undergoing Hemodialysis

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