Prevalence of pulmonary tuberculosis in western China in 2010–11: a population-based, cross-sectional survey

Mijiti, Peierdun; Li, Yuehua; Feng, Xue; Milligan, Paul; Merle, Corinne; Wu, Gang; Nianqiang, Liu; Upur, Halmurat

doi:10.1016/s2214-109x(16)30074-2

Cited by 31 publications

(41 citation statements)

References 24 publications

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“…18.3%, and 19.8%, respectively. It is consistent with the fact that the burden of TB was increasing from East China to West China 21, 22 . Considering TB prevalence in rural areas in China was approximately twice as high as it in urban areas and Shenzhen city locates in the area with low prevalence of TB 15 , it is not surprising that the higher prevalence of TB infection and of active disease among rural labor migrants might influence TB epidemic in local residents 23 .…”

Section: Discussionsupporting

confidence: 87%

Tuberculosis infection in rural labor migrants in Shenzhen, China: Emerging challenge to tuberculosis control during urbanization

Yang

Feng

et al. 2017

Sci Rep

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During China’s urbanization process, rural labor migrants have been suggested to be one important bridge population to change urban-rural distribution on tuberculosis (TB) burden. Aiming to estimate the prevalence of TB infection and to track the active disease development in rural labor migrants, a prospective study was conducted in Shenzhen city, southern China. TB infection was detected using interferon-γ release assay (IGRA). Here we mainly report the characteristics of TB infection in the study population based on the baseline survey. A total of 4,422 eligible participants completed baseline survey in July 2013. QuantiFERON (QFT) positivity rates 17.87% (790/4,422) and was found to be consistent with the local TB epidemic of the areas where the participants immigrated from. Age, smoking, residence registered place, and present of BCG scars were found to be independently associated with QFT positivity. Additionally, evidence for interaction between smoking and age was observed (p for likelihood ratio test < 0.001). Our results suggested that the development of TB control strategy including latent TB infection management should pay more attention to the rural flowing population due to their high mobility and higher prevalence of TB infection.

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Section: Discussionsupporting

confidence: 87%

Tuberculosis infection in rural labor migrants in Shenzhen, China: Emerging challenge to tuberculosis control during urbanization

Yang

Feng

et al. 2017

Sci Rep

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“…Population density was also positively correlated with SS + PTB. Similar results have been reported in other studies [46][47][48]. Due to poor financial conditions, migrants are more likely to be living in crowded places that favor the spread of Mycobacterium tuberculosis; this explains the association between population density and SS + PTB.…”

Section: Discussionsupporting

confidence: 89%

The association between internal migration and pulmonary tuberculosis in China, 2005–2015: a spatial analysis

Liao

Gao

et al. 2020

Infect Dis Poverty

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Background: Internal migration places individuals at high risk of contracting tuberculosis (TB). However, there is a scarcity of national-level spatial analyses regarding the association between TB and internal migration in China. In our research, we aimed to explore the spatial variation in cases of sputum smear-positive pulmonary TB (SS + PTB) in China; and the associations between SS + PTB, internal migration, socioeconomic factors, and demographic factors in the country between 2005 and 2015. Methods: Reported cases of SS + PTB were obtained from the national PTB surveillance system database; cases were obtained at the provincial level. Internal migration data were extracted from the national population sampling survey and the census. Spatial autocorrelations were explored using the global Moran's statistic and local indicators of spatial association. The spatial temporal analysis was performed using Kulldorff's scan statistic. Fixed effects regression was used to explore the association between SS + PTB and internal migration. Results: A total of 4 708 563 SS + PTB cases were reported in China between 2005 and 2015, of which 3 376 011 (71.7%) were male and 1 332 552 (28.3%) were female. There was a trend towards decreasing rates of SS + PTB notifications between 2005 and 2015. The result of global spatial autocorrelation indicated that there were significant spatial correlations between SS + PTB rate and internal migration each year (2005-2015). Spatial clustering of SS + PTB cases was mainly located in central and southern China and overlapped with the clusters of emigration. The proportions of emigrants and immigrants were significantly associated with SS + PTB. Per capita GDP and education level were negatively associated with SS + PTB. The internal migration flow maps indicated that migrants preferred neighboring provinces, with most migrating for work or business. Conclusions: This study found a significant spatial autocorrelation between SS + PTB and internal migration. Both emigration and immigration were statistically associated with SS + PTB, and the association with emigration was stronger than that for immigration. Further, we found that SS + PTB clusters overlapped with emigration clusters, and the internal migration flow maps suggested that migrants from SS + PTB clusters may influence the TB epidemic characteristics of neighboring provinces. These findings can help stakeholders to implement effective PTB control strategies for areas at high risk of PTB and those with high rates of internal migrants.

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“…Second, the control population in the current study were screened to exclude active TB by symptoms and chest radiography, but not for latent TB infection (LTBI). As TB is endemic in China with an estimated case detection rate of 423 per 100,000 in western China (32) it is likely that many of the healthy controls have LTBI. Both transcriptional and protein biomarkers that distinguish subjects with active TB from health controls are also negative in the vast majority of subjects with LTBI (31,33), however future studies should determine if miRNA expression is affected by LTBI.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Identification of a plasma microRNA profile in untreated pulmonary tuberculosis patients that is modulated by anti-mycobacterial therapy

Barry

Ellis

Yang

et al. 2018

Journal of Infection

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Prevalence of pulmonary tuberculosis in western China in 2010–11: a population-based, cross-sectional survey

Abstract: Xinjiang Uyghur Autonomous Region Health Bureau.

Cited by 31 publications

References 24 publications

Tuberculosis infection in rural labor migrants in Shenzhen, China: Emerging challenge to tuberculosis control during urbanization

Tuberculosis infection in rural labor migrants in Shenzhen, China: Emerging challenge to tuberculosis control during urbanization

The association between internal migration and pulmonary tuberculosis in China, 2005–2015: a spatial analysis

Identification of a plasma microRNA profile in untreated pulmonary tuberculosis patients that is modulated by anti-mycobacterial therapy

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