Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: The ROAD study

Muraki, Shigeyuki; Oka, Hiroyuki; Akune, Toru; Mabuchi, Akihiko; Enyo, Yoshio; Yoshida, Munehito; Saika, Akihiko; Suzuki, Takao; Yoshida, Hideyo; Ishibashi, Hiroyuki; Yamamoto, Seiji; Nakamura, Kozo; Kawaguchi, Hiroshi; Yoshimura, Nagahisa

doi:10.1016/j.joca.2009.04.005

Cited by 360 publications

(318 citation statements)

References 27 publications

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“…But epidemiological data supports that overall obese persons are more affected in knee OA 27,28,29 . In the present study incidence was more in normal BMI patients which was similar to Muraki S et al 30 Zhang Q et al 31 Vishal AA et al 32 & Radha MS et al 33 Out of 40 patients 22 (55%) patients were having sedentary lifestyle, 9 (22.5%) patients were having average lifestyle and 9 (22.5%) patients were laborers. Eminent Unani physicians have stated that excessive rest and lack of exercise may cause Wajaul-Mafasil 5,8,34 .…”

Section: Discussionsupporting

confidence: 85%

Evaluation of the Effect of Hijama Bi'l Shart in Waja-Ul-Mafasil (Knee Osteoarthritis): An Open Labelled Randomized Controlled Comparative Clinical Study

Khan¹,

Bhat²,

Waahid³

et al. 2017

J Biol Sci Opin

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Waja-ul-Mafasil is a type of arthralgia which involves several joints. It is a chronic degenerative disease of joints and is progressive in character, occurring in middle and later life. Aim of the study was to evaluate the effect of Hijama bi'l Shart (wet cupping) as an alternate treatment option in the management of Waja-ul-Mafasil (Osteoarthritis knee). A randomized open labelled controlled comparative clinical trial was carried out at department of Moalajat, National Institute of Unani Medicine hospital, Bengaluru for the duration of 30 days. 40 diagnosed pa tients of Waja-ulMafasil were randomly allocated to two groups i.e; group-A and group-B, each comprising of 20 patients. In group-A Hijama bi'l Shart was performed over the affected knee(s) on each visit at interval of 10 days for 30 days. The group-B patients received Majoon Suranjan 5gm twice daily for 30 days along with Hijama bi'l Shart. Subjective parameters i.e. Pain, Morning Stiffness, Difficulty in Movement and objective parameters VAS and KOOS were statistically analysed to assess the effect of intervention. There was no significant difference between the two groups concerning baseline characteristics (P>0.05). Both group-A & group-B exhibited statistically significant difference in objective parameters. In intragroup comparison VAS and KOOS showed statistically significant difference in both group-A and group-B (p<0.001). On intergroup comparison group-B showed better response on VAS with p<0.05 in both right & left knee. Hijama bi'l Shart can effectively alleviate the Waja-ul-Mafasil (knee osteoarthritis) without any side effects. The study revealed that Hijama bi'l Shart has potent analgesic & anti-inflammatory effect.

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Section: Discussionsupporting

confidence: 85%

Evaluation of the Effect of Hijama Bi'l Shart in Waja-Ul-Mafasil (Knee Osteoarthritis): An Open Labelled Randomized Controlled Comparative Clinical Study

Khan¹,

Bhat²,

Waahid³

et al. 2017

J Biol Sci Opin

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“…Genetic screen using the human osteoarhritic cartilage UniGene library suggests that HIF-2 is a potential catabolic regulator of articular cartilage (Yang et al, 2010). Based on the Japanese population ROAD study, a functional SNP in human EPAS1 proximal promoter region was associated with knee osteoarthritis in a 397 patient cohort (Muraki et al, 2009;Saito et al, 2010). Consistent with this finding, , HIF-2 expression was markedly increased in OA patients with degenerative cartilage (Saito et al, 2010;Yang et al, 2010).…”

Section: Hif-2αmentioning

confidence: 72%

Genetic Mouse Models for Osteoarthritis Research

Shen¹,

Wang²,

Jin³

et al. 2012

Principles of Osteoarthritis- Its Definition, Character, Derivation and Modality-Related Recognition

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“…Second, this study was performed in a limited local region, which may not be representative of Japan overall. For example in the Research on Osteoarthritis-osteoporosis Against Disability (ROAD) study, living in a mountainous community was a risk factor for knee OA [23,24]. Third, we used the Japanese version of the KSS2011, for which validation work using cultural adaptation methods has not yet been performed.…”

Section: Discussionmentioning

confidence: 99%

The Knee injury and Osteoarthritis Outcome Score reflects the severity of knee osteoarthritis better than the revised Knee Society Score in a general Japanese population

et al. 2016

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Purpose: The purposes of this study were to examine population-based reference data for sex-and age-related differences between the 2011 revised Knee Society Score (KSS2011) and the Knee injury and Osteoarthritis Outcome Score (KOOS), to assess the correlation between those scores and radiographic knee osteoarthritis (OA), and to validate the use of the scores in a general Japanese population. Methods: This cross-sectional study included 963 volunteers (368 males, 595 females; mean age: 54.7 years). Participants were classified into five subgroups by age: under 40, 40s, 50s, 60s, and over 70 years old. The KSS2011 and KOOS were determined using self-administered questionnaires. Weight-bearing radiographs of the bilateral knee were taken and graded according to the Kellgren-Lawrence (KL) scale. The mean KSS2011 and KOOS were compared among age groups. Correlations between the severity of knee OA and each score were assessed using multiple regression analysis. Results: The overall KSS2011 tended to gradually decrease with age. Most subscales of the KSS2011 did not show sex-related differences. Similarly, the overall KOOS and all its subscales steadily decreased by approximately 20 points per decade with age. Most subscales of the KOOS were significantly decreased in females over 50. The KL grade was significantly related to both the overall KOOS (β = −0.42, p b 0.001) and KSS2011 (β = −0.13, p = 0.001), though the correlation to the KOOS was stronger. Conclusion: The overall KSS2011 and KOOS appear to decrease with age. In this population, the KOOS reflects the severity of knee OA better than the KSS2011.

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Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: The ROAD study

Abstract: The present cross-sectional study revealed a high prevalence of radiographic knee OA in the Japanese elderly. Knee pain was strongly associated with JSN especially in men, while women tended to have knee pain even without radiographic OA.

Cited by 360 publications

References 27 publications

Evaluation of the Effect of Hijama Bi'l Shart in Waja-Ul-Mafasil (Knee Osteoarthritis): An Open Labelled Randomized Controlled Comparative Clinical Study

Evaluation of the Effect of Hijama Bi'l Shart in Waja-Ul-Mafasil (Knee Osteoarthritis): An Open Labelled Randomized Controlled Comparative Clinical Study

Genetic Mouse Models for Osteoarthritis Research

The Knee injury and Osteoarthritis Outcome Score reflects the severity of knee osteoarthritis better than the revised Knee Society Score in a general Japanese population

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