Prevalence of Red Blood Cell Alloantibodies in Pregnant Women and Hemolytic Disease of Newborn in a Tertiary Care Hospital

doi:10.20431/2456-0561.0202005

ARC Journal of Gynecology and Obstetrics

2017

DOI: 10.20431/2456-0561.0202005

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Prevalence of Red Blood Cell Alloantibodies in Pregnant Women and Hemolytic Disease of Newborn in a Tertiary Care Hospital

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2024

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Red Blood Cell Alloimmunization in Pregnancy: A Review of the Pathophysiology, Prevalence, and Risk Factors

'Adani,

Mohd Ashari,

Johan

et al. 2024

Cureus

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This review paper provides an overview of the risk factors and laboratory testing for red blood cell (RBC) alloimmunization in pregnancy. RBC alloimmunization is a significant medical issue that can cause haemolytic disease of the fetus and newborn (HDFN), leading to neonatal morbidity and mortality. Current HDFN prophylaxis targets only Rhesus D (RhD) alloimmunization, with no effective measures to prevent alloimmunization to other RBC antigen groups. Several factors can increase the risk of developing RBC alloimmunization during pregnancy, including fetomaternal haemorrhage, RBC and maternal genetic status, and previous transfusions. Identifying these risk factors is essential to execute the appropriate management strategies to minimize the risk of HDFN. The review also discusses the laboratory methods and overview of pregnancy management. The paper highlights the importance of identifying and managing the risk factors for RBC alloimmunization in pregnancy to minimize the risk of HDFN and improve neonatal outcomes.

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Red Blood Cell Alloimmunization in Pregnancy: A Review of the Pathophysiology, Prevalence, and Risk Factors

'Adani,

Mohd Ashari,

Johan

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

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Prevalence of Red Blood Cell Alloantibodies in Pregnant Women and Hemolytic Disease of Newborn in a Tertiary Care Hospital

Cited by 1 publication

References 14 publications

Red Blood Cell Alloimmunization in Pregnancy: A Review of the Pathophysiology, Prevalence, and Risk Factors

Red Blood Cell Alloimmunization in Pregnancy: A Review of the Pathophysiology, Prevalence, and Risk Factors

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